Perspectives of Coumarins

Dear Colleagues,

Coumarin (2-oxo-2H-chromene) is a heterocyclic compound bearing a benzene ring condensed with pyrone ring, and is assorted to the benzopyrone class of compounds. Coumarin and its derivatives have been proven to possess a wide range of biological activities, like antitumor, antifungal, antibacterial, anticoagulant, and anti-HIV activity. Natural coumarins are biosynthesized by plants as secondary metabolites during stress, water deprivation, wilting, pathogen attack, acting as the plants’ defense mechanism. Coumarin can be synthetically modified in order to change its biological activity, and there are many examples of synthetic coumarins with increased biological activity. Natural coumarins can be extracted from various coumarin-rich plants, like tonka beans, Melilotus officinalis, Galium odoratum, Hierochloe odorata, Lavandula angustifolia, etc. Some well-known coumarin-containing compounds with potent biological activity are aflatoxins, novobiocin, warfarin, and dicumarol.

This Special Issue scope is to bring together eminent researchers presenting their investigations of coumarin synthesis, extraction, biological activity, and potential application.

Prof. Stela Jokić
Prof. Maja Molnar
Guest Editors

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