Plant-Derived Natural Compounds in the Management of Cancer: Significance and Challenges
A special issue of Biomolecules (ISSN 2218-273X).
Deadline for manuscript submissions: closed (31 December 2019) | Viewed by 140685
Special Issue Editors
Interests: tumor biology; metal toxicity; cellular pain modulation; anti-cancer drugs; natural compounds; phytochemicals
Special Issues, Collections and Topics in MDPI journals
Interests: angiogenesis; autophagy; breast cancer; cancer (glucose) metabolism; cancer stem cells; diabetes; epithelial-mesenchymal-epithelial transition (EMT/MET); endoplasmic reticulum (ER) stress; metformin; therapeutic resistance; tumor microenvironment
Special Issues, Collections and Topics in MDPI journals
Interests: experimental mammary carcinogenesis, chemoprevention, therapy, animal models, plant-derived funtional foods, cancer cell signaling
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cancer is a major disease worldwide, contributing significantly to the social and economic burden. Therefore, there is an unmet need to develop cancer prevention strategies for those at risk and improve treatment strategies for the benefit of those that are already affected. Although several mechanisms have been proposed for the development and progression of various cancers, there remain areas that need to be explored and an urgency to tackle these processes (using anti-cancer drugs) to reduce the development and progression of cancers and improve the efficacy of cancer treatments.
Cancers often develop over years or even decades, triggered by different processes involving DNA damage, chronic inflammation, comprehensive interaction between relevant molecular pathways, and cellular cross-talk with the neighboring tissues. Only a minor part of cancers are caused by inborn pre-disposition. The absolute majority carry a sporadic character based on modifiable risk factors which play a central role in cancer prevention. Numerous studies have documented that dietary natural plant products (both whole products as well as their isolated active compounds) are able to affect the initiation, promotion, and progression of cancers. The long-term administration of multi-target phytochemicals with a plethora of biological activities can thus be the most rational and effective strategy used in medical practice in this regard.
This Special Issue focusses on the effects of plant-derived dietary factors on carcinogenesis and effective cancer treatment. It includes in-vitro- and in-vivo-based cancer models evaluating the mechanisms of action of phytochemicals on cancer; clinical investigations on the role of the plant compounds on cancer risk, treatment, and survival; novel methodological approaches to enhance the bioavailability of phytochemicals; and novel strategies for the extraction, purification, and characterization natural compounds with anticancer activity. For this Special Issue, we invite original research articles and reviews related to the role of plant-derived natural compounds on cancers.
Dr. Dietrich Büsselberg
Dr. Samson Mathews Samuel
Dr. Peter Kubatka
Guest Editors
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Keywords
- angiogenesis
- antioxidants
- apoptosis
- cancer cells
- cancer chemoprevention
- cancer stem cells
- cancer treatment
- cell cycle regulation
- epigenetic modulators
- geno-protective effects
- natural bioactive compounds
- nutraceuticals
- nutrition
- oxidative stress
- phytochemicals
- plant functional foods
- polyphenols
- terpenoids
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