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Metabolites, Volume 15, Issue 4

April 2025 - 71 articles

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Cover Story: Some dog breeds, like the miniature schnauzer pictured, are predisposed to congenital portosystemic shunts (CPSSs). These abnormal vascular connections allow portal blood to bypass the liver, resulting in metabolic irregularities. In this study, we investigated changes in serum amino acid profiles among dogs with intrahepatic and extrahepatic CPSSs, as well as healthy control dogs. Principal component analysis showed that the CPSS dogs exhibited perturbations in their amino acid profiles, differentiating them from the healthy controls but not from each other. We also evaluated the normalization of amino acid profiles following shunt attenuation surgery, concluding that post-surgical assessment of serum amino acid concentration may serve as a noninvasive tool for monitoring the restoration of liver function in these dogs. View this paper

Articles (71)

  • Article
  • Open Access
626 Views
15 Pages

Development and Application of an In-Capillary CE-DAD Method for the Inhibitory Screening of Natural Extracts Towards Acetylcholinesterase Enzyme

  • Francesca Rinaldi,
  • Sofia Salerno,
  • Elena Frigoli,
  • Giulia De Soricellis,
  • Gloria Brusotti,
  • Stefano Negri,
  • Matteo Radice,
  • Francesca Merlo,
  • Andrea Speltini and
  • Hellas Cena
  • + 1 author

18 April 2025

Background: The enzymatic activity of acetylcholinesterase (AChE) has been a focal point in neurodegenerative diseases research, particularly in relation to Alzheimer’s disease. This is attributed to the significantly reduced levels of choliner...

  • Review
  • Open Access
1 Citations
1,828 Views
27 Pages

Lipid Metabolism and Statin Therapy in Neurodegenerative Diseases: An Endocrine View

  • Antonella Di Sarno,
  • Fiammetta Romano,
  • Rossana Arianna,
  • Domenico Serpico,
  • Mariarosaria Lavorgna,
  • Silvia Savastano,
  • Annamaria Colao and
  • Carolina Di Somma

18 April 2025

Background/aim: A growing body of evidence suggests a link between dyslipidemias and neurodegenerative diseases, highlighting the crucial role of lipid metabolism in the health of the central nervous system. The aim of our work was to provide an upda...

  • Article
  • Open Access
1 Citations
882 Views
12 Pages

18 April 2025

Background: This study aims to develop a fingerprint analysis method using ultra-high performance liquid chromatography (UPLC) for Moutan Cortex sourced from different regions. The objective is to establish quality control standards validated through...

  • Article
  • Open Access
1 Citations
1,022 Views
13 Pages

17 April 2025

Background: Alpha-1-acid glycoprotein (AGP) is a glycoprotein synthesized mainly by the liver. Nonalcoholic fatty liver disease (NAFLD) and liver fibrosis (LF) are associated with metabolic disorders. The aim of this study was to examine the potentia...

  • Article
  • Open Access
745 Views
15 Pages

17 April 2025

Background/Objectives: Metabolite risk score (MRS), which considers the collective effects of metabolites closely reflecting a phenotype, is a new approach for disease assessment, moving away from focusing solely on individual biomarkers. This study...

  • Article
  • Open Access
2 Citations
1,817 Views
19 Pages

Effects of a 6-Week Concurrent Training Program Combining Resistance and Various Modalities of Aerobic Exercise in Obese Women with Prehypertension: A Randomized Controlled Trial

  • Jinhyuk Yu,
  • Eunjoo Lee,
  • Jae-Ho Choi,
  • Yerin Sun,
  • Seungyeon Woo,
  • Sohyang Cho,
  • Deunsol Hwang,
  • Sung-Woo Kim,
  • Jisu Kim and
  • Kiwon Lim
  • + 1 author

17 April 2025

Background/Objectives: Our study aimed to verify the effects of 6 weeks of concurrent training composed of resistance training (RT) and different modalities of aerobic exercise (moderate-intensity continuous training (MICT) or high-intensity interval...

  • Article
  • Open Access
987 Views
17 Pages

Metabolic Effects of the Cancer Metastasis Modulator MEMO1

  • Marziyeh Ghanbarian,
  • Natalia Dolgova,
  • Frederick S. Vizeacoumar,
  • Franco J. Vizeacoumar,
  • Deborah Michel,
  • Anas El-Aneed and
  • Oleg Y. Dmitriev

17 April 2025

Background/Objectives: Cancer cells often display altered energy metabolism. In particular, expression levels and activity of the tricarboxylic acid cycle (TCA cycle) enzymes may change in cancer, and dysregulation of the TCA cycle is a frequent hall...

  • Review
  • Open Access
15 Citations
3,914 Views
27 Pages

Plant Secondary Metabolites—Central Regulators Against Abiotic and Biotic Stresses

  • Ameer Khan,
  • Farah Kanwal,
  • Sana Ullah,
  • Muhammad Fahad,
  • Leeza Tariq,
  • Muhammad Tanveer Altaf,
  • Asad Riaz and
  • Guoping Zhang

16 April 2025

As global climates shift, plants are increasingly exposed to biotic and abiotic stresses that adversely affect their growth and development, ultimately reducing agricultural productivity. To counter these stresses, plants produce secondary metabolite...

  • Article
  • Open Access
1,584 Views
23 Pages

Targeted and Non-Targeted Metabolomic Evaluation of Cerebrospinal Fluid in Early Phase Schizophrenia: A Pilot Study from the Hopkins First Episode Psychosis Project

  • George E. Jaskiw,
  • Mark E. Obrenovich,
  • Curtis J. Donskey,
  • Farren B. S. Briggs,
  • Sun Sunnie Chung,
  • Anastasiya I. Kalinina,
  • Austin Bolomey,
  • Lindsay N. Hayes,
  • Kun Yang and
  • Robert H. Yolken
  • + 1 author

15 April 2025

(1) Background: The lack of reliable biomarkers remains a significant barrier to improving outcomes for patients with schizophrenia. While metabolomic analyses of blood, urine, and feces have been explored, results have been inconsistent. Compared to...

  • Article
  • Open Access
1 Citations
844 Views
16 Pages

Comprehensive Characterization of Serum Lipids of Dairy Cows: Effects of Negative Energy Balance on Lipid Remodelling

  • Zhiqian Liu,
  • Wenjiao Wang,
  • Joanne E. Hemsworth,
  • Coralie M. Reich,
  • Carolyn R. Bath,
  • Monique J. Berkhout,
  • Muhammad S. Tahir,
  • Vilnis Ezernieks,
  • Leah C. Marett and
  • Amanda J. Chamberlain
  • + 2 authors

15 April 2025

Background: The presence and concentration of lipids in serum of dairy cows have significant implications for both animal health and productivity and are potential biomarkers for several common diseases. However, information on serum lipid compositio...

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