Muscle Metabolic Response and Adaptation to Exercise, Diet, and Environment
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Animal Metabolism".
Deadline for manuscript submissions: 30 November 2024 | Viewed by 5147
Special Issue Editor
Special Issue Information
Dear Colleagues,
Skeletal muscle plays a crucial role as a locomotor organ and as a modulator of systemic energy homeostasis in animals. Dysregulation of muscle metabolism in humans leads to the development of serious diseases such as diabetes and sarcopenia. In farm animals, excessive pursuit of productivity sometimes causes disruption of energy homeostasis as exhibited in undesirable products such as abnormal chicken meat quality derived from disturbed mitophagy and/or redox metabolism. The optimized muscle metabolism is important for an increase in muscle mass during animal development and growth. Therefore, a better understanding of mechanisms underlying developmental regulation of metabolisms and adaptation of skeletal muscle metabolism to various inputs including diet, exercise, and environment stress contributes to further improvement of human health, animal welfare and productivity, and meat quality.
Recent metabolomics technologies, in combination with the development of bioinformatics and imaging mass spectrometry, has provided great benefits in the approach to unexplored muscle metabolisms. With these backgrounds, this Special Issue aims to share and discuss research topics focusing on molecular mechanisms of the metabolic response of skeletal muscle tissue and cells in the view of genes, transcripts, proteins, metabolites, and epigenetic factors, when exposed to various nutritional conditions and physiological stress-inducing environments. Papers addressing mechanisms of metabolic adaptation and disturbance, especially in terms of mitochondria, energy homeostasis, lipid metabolism, and redox metabolism, including cell culture studies, could be the desired topics in this issue. Meanwhile, other studies regarding skeletal muscle growth, maturation, aging, disease, and farm animal intramuscular fat and postmortem muscle aging are also welcome. Most of these studies may be conducted by use of metabolomics and integrative multi-omics approaches, but also cutting-edge studies targeting a specific key metabolite and inter-organ crosstalk around muscle in the above-mentioned fields are also acceptable.
Dr. Susumu Muroya
Guest Editor
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Keywords
- skeletal muscle
- metabolomics
- mitochondria
- energy metabolism
- lipid metabolism
- nutrition
- feeding
- environment
- exercise
- stress
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