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Metabolites, Volume 15, Issue 5

May 2025 - 61 articles

Cover Story: Tandem mass spectrometry (MS/MS) plays a key role in newborn screening (NBS) for inborn errors of metabolism (IEMs). In Italy, nearly 50 IEMs are screened; second-tier tests (2-TTs) minimize the false positive rate. We reviewed MS/MS NBS data from over 37,000 newborns (8% required 2-TTs) screened in the Abruzzo region to assess the impact of neonatal and maternal variables on propionate-related primary biomarker levels. We set up customized layered cut-offs based on these variables and applied them retrospectively to the entire population: only 1.47% of newborns would have required 2-TT, still identifying true positive cases of NBS detected over the years. Customized cut-offs may enhance the application of precision medicine, focusing on true positive cases, reducing costs and times. View this paper
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Articles (61)

  • Article
  • Open Access
1 Citations
2,236 Views
17 Pages

Background: Equally with other indigenous green leafy vegetables, Solunum nigrum L. has been widely consumed by the VhaVenda tribe found in the Limpopo Province of South Africa since ancient times as a source of food diversification due to its higher...

  • Article
  • Open Access
1 Citations
1,515 Views
18 Pages

Association Between Bioimpedance-Determined Metabolic Age and MASLD Risk Scores in Spanish Workers

  • Ignacio Ramírez-Gallegos,
  • Carla Busquets-Cortes,
  • Hernán Paublini,
  • Ángel Arturo López-González,
  • Emilio Martínez-Almoyna-Rifá,
  • Pedro Juan Tárraga López and
  • José Ignacio Ramírez-Manent

Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent liver disorder with significant metabolic implications. Metabolic age, determined through bioimpedance analysis, has emerged as a potential indicator of overa...

  • Article
  • Open Access
3 Citations
1,385 Views
13 Pages

Lipid Subclasses Differentiate Insulin Resistance by Triglyceride–Glucose Index

  • Khaled Naja,
  • Najeha Anwardeen,
  • Omar Albagha and
  • Mohamed A. Elrayess

Background: Insulin resistance is a key driver of metabolic syndrome and related disorders, yet its underlying metabolic alterations remain incompletely understood. The Triglyceride–Glucose (TyG) index is an emerging, accessible marker for insu...

  • Article
  • Open Access
1 Citations
1,171 Views
18 Pages

Effects of Exercise on Gut Microbiome and Serum Metabolomics in Post-Traumatic Osteoarthritis Rats

  • Xiaoxia Hao,
  • Xingru Shang,
  • Yiwen Zhang,
  • Wenjie Hou,
  • Ruimin Chi,
  • Chunran Pan,
  • Jiawei Liu,
  • Xiaofeng Deng,
  • Jiaming Zhang and
  • Tao Xu

Objective: The aim of this work is to investigate the impact of exercise on gut microbiome composition, serum metabolites, and their correlation with osteoarthritis (OA) severity. Methods: Thirty-six Sprague-Dawley (SD) rats were randomly divided int...

  • Article
  • Open Access
1,649 Views
15 Pages

Characterizing Plasma-Based Metabolomic Signatures for Metastasis in Non-Small Cell Lung Cancer

  • Manlu Liu,
  • Yanlong Zhu,
  • Sean J. McIlwain,
  • Haotian Deng,
  • Allan R. Brasier,
  • Ying Ge,
  • Michelle E. Kimple and
  • Andrew M. Baschnagel

Background/Objectives: The current staging of non-small cell lung cancer (NSCLC) relies on conventional imaging, which lacks the sensitivity to detect micrometastatic disease. The functional assessment of NSCLC progression may provide independent inf...

  • Article
  • Open Access
1,168 Views
18 Pages

Background: Cadmium (Cd) is a highly toxic heavy metal. There are very few studies about the effects of Cd on reproductive health and metabolism, and even fewer on metabolic disorders in the uterus of mice in labor. This study is the first to establi...

  • Article
  • Open Access
932 Views
16 Pages

A Comparative Analysis of Raw and Bran-Fried Acori tatarinowii Rhizoma Based on the Intelligent Sensory Evaluation System

  • Yingna Le,
  • Zhongjian Yang,
  • Ruiping Wang,
  • Shaolong Ma,
  • Yang Cui,
  • Kun Shi,
  • Li Xin,
  • Jinlian Zhang and
  • Lingyun Zhong

Objectives: The study aimed to investigate the differences in odor, color, and taste characteristics between raw and bran-fried Acori tatarinowii Rhizoma (RATR and BATR) using advanced sensory evaluation technologies. The objective was to establish a...

  • Article
  • Open Access
963 Views
17 Pages

Eliciting Clavulanic Acid Biosynthesis: The Impact of Bacillus velezensis FZB42 on the Metabolism of Streptoyces clavuligerus ATCC 27064

  • Luisa F. Patiño,
  • Carlos Caicedo-Montoya,
  • Laura Pinilla-Mendoza,
  • Jaison H. Cuartas and
  • Rigoberto Ríos-Estepa

Background/Objectives: Clavulanic acid (CA) is produced by cell suspension cultures of Streptomyces clavuligerus ATCC 27064, and is widely used as a beta-lactamase inhibitor to combat antibiotic resistance. CA titers are moderate due to bioprocess co...

  • Article
  • Open Access
1 Citations
1,140 Views
16 Pages

Mechanism Study on the Preventive Effect of ELITEA Compound Tea on Hyperuricemia in Rats Based on Serum Untargeted Metabolomics

  • Shulian Liu,
  • Yongliang Zhu,
  • Wenjiong Wang,
  • Xianghan Zhang,
  • Linrui Gao and
  • Xiangjun Qiu

Background/Objectives: Hyperuricemia (HUA) has become the second largest metabolic disease after diabetes, and has become a major public health problem. The ELITEA compound tea extract can effectively reduce the serum uric acid level in HUA rat model...

  • Review
  • Open Access
3 Citations
6,816 Views
42 Pages

Attention-deficit/hyperactivity disorder (ADHD) is a common childhood-onset neurodevelopmental disorder that often persists into adulthood, leading to various adverse outcomes. Its underlying pathology is multifactorial, involving neurotransmitter im...

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Metabolites - ISSN 2218-1989