Proteomics and Metabolomics in Veterinary and Animal Health

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Integrative Metabolomics".

Deadline for manuscript submissions: closed (31 March 2025) | Viewed by 852

Special Issue Editors


E-Mail Website
Guest Editor
Department of Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, Zagreb, Croatia
Interests: proteomics; metabolomics; mass spectrometry; multi-omics data integration; biomarker discovery; biomolecule function and interactions

E-Mail Website
Guest Editor
Biology of Robustness, Mediterranean Institute for Life Sciences (MedILS), Split, Croatia
Interests: omics data; bioinformatics; biostatistics; multi-omics data integration; systems biology

Special Issue Information

Dear Colleagues,

Omics sciences have infiltrated all scientific areas of research over the past few years. As such, proteomics and metabolomics have also been widely explored in veterinary medicine research, showing their full potential in deciphering various pathophysiological processes in animal health and disease at the molecular level. By applying advanced bioinformatic and statistical tools, the integration of multiomics data provides deeper insights into biological pathways and complex molecular interplay, highlighting the key molecules of interest from diagnostic, prognostic, and drug development perspectives. Furthermore, given the ethical concerns of animals as animal models, as well as animal welfare, the omics approach in veterinary medicine can provide a significant contribution to physiopathology studies for human diseases as part of comparative medicine.

This Special Issue is devoted to topics covering (not exclusively) studies on the application of metabolomics or multiomics layers, namely various proteomic and metabolomics strategies, combined with statistical models and/or bioinformatics approaches in animal health and disease. We strongly encourage you to share your valuable findings in this topic and contribute to the development of new analytical strategies, databases, and bioinformatics workflows in animal research and finally to animal welfare.

Dr. Anita Horvatić
Dr. Andrea Gelemanović
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metabolomics
  • proteomics
  • bioinformatics
  • omics data integration
  • mass spectrometry
  • veterinary medicine
  • animal health
  • biomarker discovery
  • metabolic pathways
  • molecular interactions

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

17 pages, 1220 KiB  
Article
Serum Amino Acid Profiles in Dogs with a Congenital Portosystemic Shunt
by Robert Kyle Phillips, Amanda B. Blake, Michael S. Tivers, Alex Chan, Patricia E. Ishii, Jan S. Suchodolski, Jörg M. Steiner and Jonathan A. Lidbury
Metabolites 2025, 15(4), 258; https://doi.org/10.3390/metabo15040258 - 9 Apr 2025
Viewed by 406
Abstract
Background/Objectives: A functional liver is vital for normal protein metabolism. Alterations of circulating amino acid (AA) concentrations have previously been reported in dogs with hepatocellular carcinoma, chronic hepatitis, and hepatocutaneous syndrome. The purpose of this study was to compare serum AA profiles [...] Read more.
Background/Objectives: A functional liver is vital for normal protein metabolism. Alterations of circulating amino acid (AA) concentrations have previously been reported in dogs with hepatocellular carcinoma, chronic hepatitis, and hepatocutaneous syndrome. The purpose of this study was to compare serum AA profiles between dogs with a congenital portosystemic shunt (CPSS) and healthy control dogs. Methods: Serum samples were collected from 50 dogs with an extrahepatic congenital portosystemic shunt (eCPSS) and 10 dogs with an intrahepatic congenital portosystemic shunt (iCPSS) at time of surgical intervention and from 21 healthy control dogs. Serum AA and other nitrogenous compounds were measured with a dedicated amino acid analyzer. The concentration of each AA was compared between groups using a Kruskal–Wallis test followed by Dunn’s multiple comparisons tests, as appropriate. The Benjamini–Hochberg procedure was used to control for false discovery. Significance was set at q < 0.05. Results: Compared to healthy controls, dogs with a CPSS had significantly increased serum concentrations of ammonia, asparagine, glutamic acid, histidine, phenylalanine, serine, and tyrosine and had significantly decreased concentrations of isoleucine, leucine, threonine, urea, and valine. There were no significant differences in serum AA concentrations between dogs with an eCPSS and dogs with an iCPSS. Conclusions: Dogs with a CPSS had altered serum AA concentrations compared to healthy control dogs, including decreased branched-chain amino acids (BCAAs) and increased aromatic amino acids (AAAs). In summary, serum AA profiles can differentiate dogs with a CPSS from healthy dogs but not dogs with an eCPSS from dogs with an iCPSS. Full article
(This article belongs to the Special Issue Proteomics and Metabolomics in Veterinary and Animal Health)
Show Figures

Figure 1

Back to TopTop