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Metabolites, Volume 11, Issue 12

2021 December - 94 articles

Cover Story: Methotrexate remains the cornerstone of disease-modifying therapy in the treatment of rheumatoid arthritis based on its efficacy, toxicity profile, and economic merits. While methotrexate has been proven to slow disease progression, minimizing damage to tissues and joints, it is often characterized by a highly variable response and a delayed onset of action. Approximately two-thirds of patients fail to have an adequate response to methotrexate alone and will require additional therapies, such as biologics. This study evaluates changes in the plasma metabolome associated with response to methotrexate in rheumatoid arthritis over a 16-week treatment period with the goal of understanding the metabolic basis for methotrexate efficacy and toward the identification of potential metabolic biomarkers of methotrexate response. View this paper.
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Articles (94)

  • Article
  • Open Access
15 Citations
3,261 Views
17 Pages

Effect of the Length of Oat Hay on Growth Performance, Health Status, Behavior Parameters and Rumen Fermentation of Holstein Female Calves

  • Jianxin Xiao,
  • Tianyu Chen,
  • Gibson Maswayi Alugongo,
  • Muhammad Zahoor Khan,
  • Tingting Li,
  • Jing Ma,
  • Shuai Liu,
  • Wei Wang,
  • Yajing Wang and
  • Zhijun Cao
  • + 1 author

20 December 2021

The aim of this study was to evaluate the effect of the length of oat hay on the performance, health, behavior, and rumen fermentation of dairy calves. For this purpose, two hundred and ten healthy two-day-old Holstein dairy calves were randomly allo...

  • Feature Paper
  • Article
  • Open Access
9 Citations
4,454 Views
23 Pages

1H-Nuclear Magnetic Resonance Analysis of Urine as Diagnostic Tool for Organic Acidemias and Aminoacidopathies

  • Ninna Pulido,
  • Johana M. Guevara-Morales,
  • Alexander Rodriguez-López,
  • Álvaro Pulido,
  • Jhon Díaz,
  • Ru Angelie Edrada-Ebel and
  • Olga Y. Echeverri-Peña

20 December 2021

The utility of low-resolution 1H-NMR analysis for the identification of biomarkers provided evidence for rapid biochemical diagnoses of organic acidemia and aminoacidopathy. 1H-NMR, with a sensitivity expected for a field strength of 400 MHz at 64 sc...

  • Review
  • Open Access
4 Citations
3,943 Views
15 Pages

19 December 2021

The heart is a metabolic omnivore that combusts a considerable amount of energy substrates, mainly long-chain fatty acids (FAs) and others such as glucose, lactate, ketone bodies, and amino acids. There is emerging evidence that muscle-type continuou...

  • Article
  • Open Access
1 Citations
2,988 Views
11 Pages

The Effect of Glucose and Poloxamer 188 on Red-Blood-Cell Aggregation

  • Alicja Szołna-Chodór and
  • Bronisław Grzegorzewski

18 December 2021

Glucose metabolism disorders contribute to the development of various diseases. Numerous studies show that these disorders not only change the normal values of biochemical parameters but also affect the mechanical properties of blood. To show the inf...

  • Article
  • Open Access
18 Citations
4,054 Views
9 Pages

Association of Neonatal Jaundice with Gut Dysbiosis Characterized by Decreased Bifidobacteriales

  • Shohei Akagawa,
  • Yuko Akagawa,
  • Sohsaku Yamanouchi,
  • Yoshiki Teramoto,
  • Masahiro Yasuda,
  • Sadayuki Fujishiro,
  • Jiro Kino,
  • Masato Hirabayashi,
  • Kenji Mine and
  • Kazunari Kaneko
  • + 4 authors

18 December 2021

Neonatal jaundice, caused by excess serum bilirubin levels, is a common condition in neonates. Imbalance in the gut microbiota is believed to play a role in the development of neonatal jaundice. Thus, we aimed to reveal the gut microbiota characteris...

  • Article
  • Open Access
17 Citations
4,098 Views
15 Pages

Optimized Workflow for On-Line Derivatization for Targeted Metabolomics Approach by Gas Chromatography-Mass Spectrometry

  • Raphaela Fritsche-Guenther,
  • Yoann Gloaguen,
  • Anna Bauer,
  • Tobias Opialla,
  • Stefan Kempa,
  • Christina A. Fleming,
  • Henry Paul Redmond and
  • Jennifer A. Kirwan

18 December 2021

Using manual derivatization in gas chromatography-mass spectrometry samples have varying equilibration times before analysis which increases technical variability and limits the number of potential samples analyzed. By contrast, automated derivatizat...

  • Article
  • Open Access
25 Citations
4,305 Views
20 Pages

Comparative Metabolomics Reveals Two Metabolic Modules Affecting Seed Germination in Rice (Oryza sativa)

  • Hao Guo,
  • Yuanyuan Lyv,
  • Weikang Zheng,
  • Chenkun Yang,
  • Yufei Li,
  • Xuyang Wang,
  • Ridong Chen,
  • Chao Wang,
  • Jie Luo and
  • Lianghuan Qu

17 December 2021

The process of seed germination is crucial not only for the completion of the plant life cycle but also for agricultural production and food chemistry; however, the underlying metabolic regulation mechanism involved in this process is still far from...

  • Article
  • Open Access
5 Citations
4,108 Views
11 Pages

Reduced Fatty Acid Use from CD36 Deficiency Deteriorates Streptozotocin-Induced Diabetic Cardiomyopathy in Mice

  • Yogi Umbarawan,
  • Ryo Kawakami,
  • Mas Rizky A. A. Syamsunarno,
  • Hideru Obinata,
  • Aiko Yamaguchi,
  • Hirofumi Hanaoka,
  • Takako Hishiki,
  • Noriyo Hayakawa,
  • Norimichi Koitabashi and
  • Tatsuya Iso
  • + 3 authors

17 December 2021

Cardiac dysfunction is induced by multifactorial mechanisms in diabetes. Deranged fatty acid (FA) utilization, known as lipotoxicity, has long been postulated as one of the upstream events in the development of diabetic cardiomyopathy. CD36, a transm...

  • Review
  • Open Access
7 Citations
3,797 Views
8 Pages

Obesogens in Children—An Uncharted Territory

  • Mirjam Močnik and
  • Nataša Marčun Varda

17 December 2021

Obesogens are exogenous chemicals belonging to the group of endocrine-disrupting chemicals and are believed to interfere in obesity development. In children, several chemicals are under investigation, most commonly bisphenol A, phthalates, perfluorin...

  • Article
  • Open Access
11 Citations
3,909 Views
17 Pages

Metabolic Fluctuations in the Human Stool Obtained from Blastocystis Carriers and Non-Carriers

  • Emma L. Betts,
  • Jamie M. Newton,
  • Gary S. Thompson,
  • Fakhriddin Sarzhanov,
  • Vasana Jinatham,
  • Moon-Ju Kim,
  • Siam Popluechai,
  • Funda Dogruman-Al,
  • Eun-Jeong Won and
  • Anastasios D. Tsaousis
  • + 1 author

17 December 2021

Blastocystis is an obligate anaerobic microbial eukaryote that frequently inhabits the gastrointestinal tract. Despite this prevalence, very little is known about the extent of its genetic diversity, pathogenicity, and interaction with the rest of th...

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Metabolites - ISSN 2218-1989