Special Issue "Metabolomics 2021 Online"

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Frontiers in Metabolomics".

Deadline for manuscript submissions: 1 December 2021.

Special Issue Editors

Dr. Krista Zanetti
E-Mail Website
Guest Editor
National Cancer Institute, Rockville, MD 20850, USA
Interests: metabolomics; epidemiology; omics data integration
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Horst Joachim Schirra
E-Mail Website
Guest Editor
School of Environment and Science, and Griffith Institute for Drug Discovery, Griffith University, Nathan, QLD 4111, Australia
Interests: NMR spectroscopy; metabolomics; C. elegans; genome-scale models; metabolic regulation; gasotransmitters; mitochondrial metabolism; hypometabolism; environmental metabolomics; foodomicsh

Special Issue Information

Dear Colleagues,

This Special Issue of Metabolites is the conference issue dedicated to Metabolomics 2021 Online.

For this Special Issue, we particularly, but not exclusively, welcome papers presented at or resulting from Metabolomics 2021 Online, the second virtual conference of the Metabolomics Society that took place from 22–24 June 2021. The focus of this issue is topics relevant to metabolomic science.

More information about the Metabolomics 2021 Online conference can be found at: https://metabolomics2021.org/.

We look forward to reading your papers! 

Dr. Krista Zanetti
Prof. Dr. Horst Joachim Schirra
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

Article
Metabolomic Changes in Naturally MAP-Infected Holstein–Friesian Heifers Indicate Immunologically Related Biochemical Reprogramming
Metabolites 2021, 11(11), 727; https://doi.org/10.3390/metabo11110727 - 23 Oct 2021
Viewed by 704
Abstract
Johne’s disease, caused by Mycobacterium avium subsp. paratuberculosis (MAP), causes weight loss, diarrhoea, and reduced milk yields in clinically infected cattle. Asymptomatic, subclinically infected cattle shed MAP bacteria but are frequently not detected by diagnostic tests. Herein, we compare the metabolite profiles of [...] Read more.
Johne’s disease, caused by Mycobacterium avium subsp. paratuberculosis (MAP), causes weight loss, diarrhoea, and reduced milk yields in clinically infected cattle. Asymptomatic, subclinically infected cattle shed MAP bacteria but are frequently not detected by diagnostic tests. Herein, we compare the metabolite profiles of sera from subclinically infected Holstein–Friesian heifers and antibody binding to selected MAP antigens. The study used biobanked serum samples from 10 naturally MAP-infected and 10 control heifers, sampled monthly from ~1 to 19 months of age. Sera were assessed using flow infusion electrospray–high-resolution mass spectrometry (FIE–HRMS) on a Q Exactive hybrid quadrupole–Orbitrap mass spectrometer for high-throughput, sensitive, non-targeted metabolite fingerprinting. Partial least-squares discriminant analyses (PLS-DA) and hierarchical cluster analysis (HCA) of the data discriminated between naturally MAP-infected and control heifers. In total, 33 metabolites that differentially accumulated in naturally MAP-infected heifers compared to controls were identified. Five were significantly elevated within MAP-infected heifers throughout the study, i.e., leukotriene B4, bicyclo prostaglandin E2 (bicyclo PGE2), itaconic acid, 2-hydroxyglutaric acid and N6-acetyl-L-lysine. These findings highlight the potential of metabolomics in the identification of novel MAP diagnostic markers and particular biochemical pathways, which may provide insights into the bovine immune response to MAP. Full article
(This article belongs to the Special Issue Metabolomics 2021 Online)
Show Figures

Graphical abstract

Back to TopTop