Table of Contents
Metabolites, Volume 10, Issue 6 (June 2020) – 50 articles
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Cover Story (view full-size image) Differentiation of preadipocytes into mature adipocytes is a highly complex cellular process which [...] Read more. Differentiation of preadipocytes into mature adipocytes is a highly complex cellular process which is still not fully characterized. In this article, we describe the longitudinal lipidomics analysis of the adipogenesis of human SGBS cell strain model with the Sciex LipidyzerTM technology which enabled the quantification of > 700 individual lipid species from 11 major lipid classes. This broad coverage allowed us to detect massive alterations within both lipid species and lipid class composition during the differentiation process. Starting from a rather heterogeneous lipid composition, the lipidome became homogenous in the fully differentiated cells. Furthermore, correlation analyses point to a possible lipid remodelling between different lipid classes during the adipogenesis process. View this paper