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Metabolites, Volume 10, Issue 6

June 2020 - 50 articles

Cover Story: Differentiation of preadipocytes into mature adipocytes is a highly complex cellular process which is still not fully characterized. In this article, we describe the longitudinal lipidomics analysis of the adipogenesis of human SGBS cell strain model with the Sciex LipidyzerTM technology which enabled the quantification of > 700 individual lipid species from 11 major lipid classes. This broad coverage allowed us to detect massive alterations within both lipid species and lipid class composition during the differentiation process. Starting from a rather heterogeneous lipid composition, the lipidome became homogenous in the fully differentiated cells. Furthermore, correlation analyses point to a possible lipid remodelling between different lipid classes during the adipogenesis process. View this paper
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Articles (50)

  • Article
  • Open Access
40 Citations
5,621 Views
19 Pages

Modulation of the Tomato Fruit Metabolome by LED Light

  • Nikolaos Ntagkas,
  • Ric C. H. de Vos,
  • Ernst J. Woltering,
  • Celine C. S. Nicole,
  • Caroline Labrie and
  • Leo F. M. Marcelis

Metabolic profiles of tomatoes change during ripening and light can modulate the activity of relevant biochemical pathways. We investigated the effects of light directly supplied to the fruits on the metabolome of the fruit pericarp during ripening....

  • Article
  • Open Access
23 Citations
5,100 Views
18 Pages

Plasma Lipid Profile Reveals Plasmalogens as Potential Biomarkers for Colon Cancer Screening

  • Anna Maria A.P. Fernandes,
  • Marcia C.F. Messias,
  • Gustavo H.B. Duarte,
  • Gabrielle K.D. de Santis,
  • Giovana C. Mecatti,
  • Andreia M. Porcari,
  • Michael Murgu,
  • Ana Valéria C. Simionato,
  • Thalita Rocha and
  • Carlos A.R. Martinez
  • + 1 author

In this era of precision medicine, there is an increasingly urgent need for highly sensitive tests for detecting tumors such as colon cancer (CC), a silent disease where the first symptoms may take 10–15 years to appear. Mass spectrometry-based...

  • Review
  • Open Access
22 Citations
6,031 Views
12 Pages

The periparturient period is the period from three weeks before calving to three weeks post-calving. This period is important in terms of health, productivity and profitability, and is fundamental to successful lactation. During this period, the anim...

  • Review
  • Open Access
28 Citations
5,941 Views
18 Pages

Oxylipin Response to Acute and Chronic Exercise: A Systematic Review

  • Étore F. Signini,
  • David C. Nieman,
  • Claudio D. Silva,
  • Camila A. Sakaguchi and
  • Aparecida M. Catai

Oxylipins are oxidized compounds of polyunsaturated fatty acids that play important roles in the body. Recently, metabololipidomic-based studies using advanced mass spectrometry have measured the oxylipins generated during acute and chronic physical...

  • Article
  • Open Access
23 Citations
4,316 Views
17 Pages

Vibrio harveyi Infection Significantly Alters Amino Acid and Carbohydrate Metabolism in Whiteleg Shrimp, Litopenaeus vannamei

  • Seohee Ma,
  • Ahran Kim,
  • Wonho Lee,
  • Seonghye Kim,
  • Sujin Lee,
  • Dahye Yoon,
  • Jin-Sol Bae,
  • Chan-Il Park and
  • Suhkmann Kim

Vibrio harveyi is one of the pathogens that threaten the shrimp farming industry. However, metabolic changes induced by V. harveyi infection in shrimp remain unknown. In this study, we first conducted high resolution-magic angle spinning (HR-MAS) nuc...

  • Article
  • Open Access
16 Citations
5,470 Views
17 Pages

Revisiting Five Years of CASMI Contests with EPA Identification Tools

  • Andrew D. McEachran,
  • Alex Chao,
  • Hussein Al-Ghoul,
  • Charles Lowe,
  • Christopher Grulke,
  • Jon R. Sobus and
  • Antony J. Williams

Software applications for high resolution mass spectrometry (HRMS)-based non-targeted analysis (NTA) continue to enhance chemical identification capabilities. Given the variety of available applications, determining the most fit-for-purpose tools and...

  • Article
  • Open Access
15 Citations
4,716 Views
16 Pages

Epilepsy not-otherwise-specified (ENOS) is one of the most common causes of chronic disorders impacting human health, with complex multifactorial etiology and clinical presentation. Understanding the metabolic processes associated with the disorder m...

  • Review
  • Open Access
32 Citations
4,036 Views
21 Pages

A large-scale nuclear event has the ability to inflict mass casualties requiring point-of-care and laboratory-based diagnostic and prognostic biomarkers to inform victim triage and appropriate medical intervention. Extensive progress has been made to...

  • Article
  • Open Access
19 Citations
4,936 Views
13 Pages

Tumor Tissue-Specific Biomarkers of Colorectal Cancer by Anatomic Location and Stage

  • Yuping Cai,
  • Nicholas J. W. Rattray,
  • Qian Zhang,
  • Varvara Mironova,
  • Alvaro Santos-Neto,
  • Engjel Muca,
  • Ana K. Rosen Vollmar,
  • Kuo-Shun Hsu,
  • Zahra Rattray and
  • Justin R. Cross
  • + 4 authors

The progress in the discovery and validation of metabolite biomarkers for the detection of colorectal cancer (CRC) has been hampered by the lack of reproducibility between study cohorts. The majority of discovery-phase biomarker studies have used pat...

  • Communication
  • Open Access
22 Citations
4,384 Views
7 Pages

Microbial Metabolite Urolithin B Inhibits Recombinant Human Monoamine Oxidase A Enzyme

  • Rajbir Singh,
  • Sandeep Chandrashekharappa,
  • Praveen Kumar Vemula,
  • Bodduluri Haribabu and
  • Venkatakrishna Rao Jala

Urolithins are gut microbial metabolites derived from ellagitannins (ET) and ellagic acid (EA), and shown to exhibit anticancer, anti-inflammatory, anti-microbial, anti-glycative and anti-oxidant activities. Similarly, the parent molecules, ET and EA...

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Metabolites - ISSN 2218-1989