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Microbial Metabolite Urolithin B Inhibits Recombinant Human Monoamine Oxidase A Enzyme

1
Department of Microbiology and Immunology, James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
2
Institute for Stem Cell Science and Regenerative Medicine (inStem), University of Agricultural Sciences-Gandhi Krishi Vignan Kendra (UAS-GKVK) Campus, Bellary Road, Bangalore, Karnataka 560065, India
*
Author to whom correspondence should be addressed.
Metabolites 2020, 10(6), 258; https://doi.org/10.3390/metabo10060258
Received: 7 May 2020 / Revised: 9 June 2020 / Accepted: 17 June 2020 / Published: 19 June 2020
(This article belongs to the Special Issue Nutrition, Microbiota and Metabolism)
Urolithins are gut microbial metabolites derived from ellagitannins (ET) and ellagic acid (EA), and shown to exhibit anticancer, anti-inflammatory, anti-microbial, anti-glycative and anti-oxidant activities. Similarly, the parent molecules, ET and EA are reported for their neuroprotection and antidepressant activities. Due to the poor bioavailability of ET and EA, the in vivo functional activities cannot be attributed exclusively to these compounds. Elevated monoamine oxidase (MAO) activities are responsible for the inactivation of monoamine neurotransmitters in neurological disorders, such as depression and Parkinson’s disease. In this study, we examined the inhibitory effects of urolithins (A, B and C) and EA on MAO activity using recombinant human MAO-A and MAO-B enzymes. Urolithin B was found to be a better MAO-A enzyme inhibitor among the tested urolithins and EA with an IC50 value of 0.88 µM, and displaying a mixed mode of inhibition. However, all tested compounds exhibited higher IC50 (>100 µM) for MAO-B enzyme. View Full-Text
Keywords: microbial metabolites; urolithins; monoamine oxidase microbial metabolites; urolithins; monoamine oxidase
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MDPI and ACS Style

Singh, R.; Chandrashekharappa, S.; Vemula, P.K.; Haribabu, B.; Jala, V.R. Microbial Metabolite Urolithin B Inhibits Recombinant Human Monoamine Oxidase A Enzyme. Metabolites 2020, 10, 258. https://doi.org/10.3390/metabo10060258

AMA Style

Singh R, Chandrashekharappa S, Vemula PK, Haribabu B, Jala VR. Microbial Metabolite Urolithin B Inhibits Recombinant Human Monoamine Oxidase A Enzyme. Metabolites. 2020; 10(6):258. https://doi.org/10.3390/metabo10060258

Chicago/Turabian Style

Singh, Rajbir, Sandeep Chandrashekharappa, Praveen K. Vemula, Bodduluri Haribabu, and Venkatakrishna R. Jala. 2020. "Microbial Metabolite Urolithin B Inhibits Recombinant Human Monoamine Oxidase A Enzyme" Metabolites 10, no. 6: 258. https://doi.org/10.3390/metabo10060258

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