Tumor Tissue-Specific Biomarkers of Colorectal Cancer by Anatomic Location and Stage
Abstract
1. Introduction
2. Results
2.1. Metabolic Differences between Colon Cancer and Normal Controls
2.2. Distinct Metabolomic Signatures Associated with Anatomic Location
2.3. Potential Metabolic Biomarkers for Early-Stage LCC and RCC
3. Discussion
4. Materials and Methods
4.1. Chemicals
4.2. Sample Collection
4.3. Tissue Metabolite Extraction
4.4. UPLC-MS Analysis
4.5. UPLC-MS Data Processing
4.6. Statistical Analysis
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Metabolite | m/z | RT | FC a | VIP b | pc | pd | pe | pf |
---|---|---|---|---|---|---|---|---|
SAH | 385.1282 | 363.2 | 0.29 | 1.8 | 0.028 | 0.001 | 0.026 | N.S. |
Formylmethionine | 176.0393 | 188.9 | 0.64 | 1.9 | 0.010 | <0.001 | 0.033 | N.S. |
Fucose 1-phosphate | 243.0285 | 438.0 | 0.38 | 1.3 | 0.026 | 0.001 | 0.010 | N.S. |
Lactate | 89.0233 | 218.2 | 0.75 | 2.1 | 0.008 | 0.046 | N.S. | N.S. |
Phenylalanine | 207.1130 | 252.0 | 0.53 | 2.3 | 0.003 | 0.019 | N.S. | N.S. |
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Cai, Y.; Rattray, N.J.W.; Zhang, Q.; Mironova, V.; Santos-Neto, A.; Muca, E.; Vollmar, A.K.R.; Hsu, K.-S.; Rattray, Z.; Cross, J.R.; et al. Tumor Tissue-Specific Biomarkers of Colorectal Cancer by Anatomic Location and Stage. Metabolites 2020, 10, 257. https://doi.org/10.3390/metabo10060257
Cai Y, Rattray NJW, Zhang Q, Mironova V, Santos-Neto A, Muca E, Vollmar AKR, Hsu K-S, Rattray Z, Cross JR, et al. Tumor Tissue-Specific Biomarkers of Colorectal Cancer by Anatomic Location and Stage. Metabolites. 2020; 10(6):257. https://doi.org/10.3390/metabo10060257
Chicago/Turabian StyleCai, Yuping, Nicholas J. W. Rattray, Qian Zhang, Varvara Mironova, Alvaro Santos-Neto, Engjel Muca, Ana K. Rosen Vollmar, Kuo-Shun Hsu, Zahra Rattray, Justin R. Cross, and et al. 2020. "Tumor Tissue-Specific Biomarkers of Colorectal Cancer by Anatomic Location and Stage" Metabolites 10, no. 6: 257. https://doi.org/10.3390/metabo10060257
APA StyleCai, Y., Rattray, N. J. W., Zhang, Q., Mironova, V., Santos-Neto, A., Muca, E., Vollmar, A. K. R., Hsu, K.-S., Rattray, Z., Cross, J. R., Zhang, Y., Paty, P. B., Khan, S. A., & Johnson, C. H. (2020). Tumor Tissue-Specific Biomarkers of Colorectal Cancer by Anatomic Location and Stage. Metabolites, 10(6), 257. https://doi.org/10.3390/metabo10060257