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Biology, Volume 13, Issue 8

August 2024 - 94 articles

Cover Story: Small open reading frames (sORFs; fewer than 300 nucleotides) are short DNA sequences that can regulate cellular processes or produce functional peptides. Identifying these sORFs, especially in non-genic regions, remains challenging despite advances in sequencing technology. D-sORF is a novel machine learning framework designed to identify putative functional sORFs in the human genome. By leveraging statistical nucleotide context and motif information around start codons, D-sORF achieves high accuracy and precision in detecting coding sORFs. Unlike traditional methods, it relies exclusively on genomic sequence data, avoiding potential biases associated with conservation parameters. Compared to phylogenetic and conservation approaches like PhyloP and PhastCon, D-sORF demonstrates superior effectiveness in recognizing coding ORFs. View this paper
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Articles (94)

  • Article
  • Open Access
2,028 Views
18 Pages

22 August 2024

Current sampling methods for detecting the presence of the invasive freshwater hydrozoan Craspedacusta sowerbii rely mainly on visual confirmation of the medusa stage. Confirming the presence of the polyp stage is equally important for observing medu...

  • Article
  • Open Access
1,643 Views
15 Pages

LncRNA495810 Promotes Proliferation and Migration of Hepatocellular Carcinoma Cells by Interacting with FABP5

  • Haili Wu,
  • Haiyan Yuan,
  • Yiwei Duan,
  • Guangjun Li,
  • Jin’e Du,
  • Panfeng Wang and
  • Zhuoyu Li

22 August 2024

Hepatocellular carcinoma (HCC) is one of the malignant tumors with high morbidity and mortality. Long non-coding RNAs (lncRNAs) are frequently dysregulated in human cancers and play an important role in the initiation and progression of HCC. Here, we...

  • Review
  • Open Access
2,511 Views
18 Pages

Trait Variation and Spatiotemporal Dynamics across Avian Secondary Contact Zones

  • Shangyu Wang,
  • Lei Wu,
  • Qianghui Zhu,
  • Jiahao Wu,
  • Shiyu Tang,
  • Yifang Zhao,
  • Yalin Cheng,
  • Dezhi Zhang,
  • Gexia Qiao and
  • Runzhi Zhang
  • + 1 author

22 August 2024

A secondary contact zone (SCZ) is an area where incipient species or divergent populations may meet, mate, and hybridize. Due to the diverse patterns of interspecific hybridization, SCZs function as field labs for illuminating the on-going evolutiona...

  • Article
  • Open Access
1 Citations
1,907 Views
21 Pages

Variation in the Health Status of the Mediterranean Gorgonian Forests: The Synergistic Effect of Marine Heat Waves and Fishing Activity

  • Martina Canessa,
  • Rosella Bertolotto,
  • Federico Betti,
  • Marzia Bo,
  • Alessandro Dagnino,
  • Francesco Enrichetti,
  • Margherita Toma and
  • Giorgio Bavestrello

21 August 2024

Over the past thirty years, the red gorgonian Paramuricea clavata in the Mediterranean Sea has faced increasing threats, including heat waves and human activities such as artisanal and recreational fishing. Epibiosis on damaged gorgonian colonies is...

  • Review
  • Open Access
8 Citations
4,446 Views
14 Pages

21 August 2024

Modulating gut microbiota composition through probiotic administration has been proposed as a novel therapy for type 2 diabetes mellitus (T2DM), and fermented milk is arguably the most common and ideal probiotic carrier. The present meta-analysis was...

  • Article
  • Open Access
1 Citations
1,359 Views
16 Pages

21 August 2024

To investigate the ecological impacts of macroalgae in the framework of shifting global CO2 concentrations, we conducted a study utilizing Ulva fasciata and Sargassum horneri specimens sourced from the Ma’an Archipelago in Zhejiang Province on...

  • Article
  • Open Access
1 Citations
2,419 Views
18 Pages

21 August 2024

According to many research groups, high glucose induces the overproduction of superoxide anions, with reactive oxygen species (ROS) generally being considered the link between high glucose levels and the toxicity seen at cellular levels. Respiratory...

  • Review
  • Open Access
9 Citations
9,672 Views
27 Pages

Deciphering Depression: Epigenetic Mechanisms and Treatment Strategies

  • Alaa A. A. Aljabali,
  • Almuthanna K. Alkaraki,
  • Omar Gammoh,
  • Murtaza M. Tambuwala,
  • Vijay Mishra,
  • Yachana Mishra,
  • Sk. Sarif Hassan and
  • Mohamed El-Tanani

20 August 2024

Depression, a significant mental health disorder, is under intense research scrutiny to uncover its molecular foundations. Epigenetics, which focuses on controlling gene expression without altering DNA sequences, offers promising avenues for innovati...

  • Case Report
  • Open Access
1 Citations
2,839 Views
15 Pages

Assessment of Extracellular Matrix Fibrous Elements in Male Dermal Aging: A Ten-Year Follow-Up Preliminary Case Study

  • Bogusław Machaliński,
  • Dorota Oszutowska-Mazurek,
  • Przemyslaw Mazurek,
  • Mirosław Parafiniuk,
  • Paweł Szumilas,
  • Alicja Zawiślak,
  • Małgorzata Zaremba,
  • Iwona Stecewicz,
  • Piotr Zawodny and
  • Barbara Wiszniewska

20 August 2024

Skin aging is a complex phenomenon influenced by multiple internal and external factors that can lead to significant changes in skin structure, particularly the degradation of key extracellular matrix (ECM) components such as collagen and elastic fib...

  • Article
  • Open Access
1 Citations
4,371 Views
23 Pages

20 August 2024

In ataxia disorders, motor incoordination (ataxia) is primarily linked to the dysfunction and degeneration of cerebellar Purkinje cells (PCs). In spinocerebellar ataxia 6 (SCA6), for example, decreased BDNF–TrkB signalling appears to contribute...

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Biology - ISSN 2079-7737Creative Common CC BY license