Gut Microbiome in Health and Disease (2nd Edition)

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Microbiology".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 1156

Special Issue Editors

College of Food Science and Technology, Zhejiang University of Technology, Hangzhou 310014, China
Interests: probiotics; insulin resistance; obesity; gut microbiota; bile acids
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Guest Editor
College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, China
Interests: bioactive peptides; fatty acids; hyperuricemia; metabolic syndrome; immune response; ‘gut-X’ axis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

There is an increasing interest in elucidating how the gut microbiome modulates our physiology, both in health and disease. Recent technological advancements and expanded efforts have led to tremendous growth in our collective knowledge of the host microbiome. The purpose of this Special Issue is to collect what is known about the gut microbiome and how it is connected to the development of disease, and to identify the bacterial and biochemical targets. In addition, this Special Issue is also concerned with the nutrition–gut microbiome–physiology axis.

This Special Issue welcomes research papers and reviews that cover a wide range of topics, including food nutrition and the gut microbiome, as well as metabolite biomarkers and underlying mechanisms. We hope to expand upon what is currently known about the gut microbiota in this Special Issue by collecting cutting-edge findings in order to shed light on how the gut microbiome can control health and disease.

Dr. Hao Zhong
Prof. Dr. Fengqin Feng
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gut microbiota
  • ‘gut-x’ axis
  • dysbiosis
  • food nutrition
  • metabolites
  • type 2 diabetes mellitus
  • gut health
  • immunity

Related Special Issue

Published Papers (2 papers)

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Research

22 pages, 1882 KiB  
Article
Effects of Inducible Nitric Oxide Synthase (iNOS) Gene Knockout on the Diversity, Composition, and Function of Gut Microbiota in Adult Zebrafish
by Yajuan Huang, Yadong Chen, Haisheng Xie, Yidong Feng, Songlin Chen and Baolong Bao
Biology 2024, 13(6), 372; https://doi.org/10.3390/biology13060372 - 23 May 2024
Viewed by 226
Abstract
The gut microbiota constitutes a complex ecosystem that has an important impact on host health. In this study, genetically engineered zebrafish with inducible nitric oxide synthase (iNOS or NOS2) knockout were used as a model to investigate the effects of nos2a/nos2b [...] Read more.
The gut microbiota constitutes a complex ecosystem that has an important impact on host health. In this study, genetically engineered zebrafish with inducible nitric oxide synthase (iNOS or NOS2) knockout were used as a model to investigate the effects of nos2a/nos2b gene single knockout and nos2 gene double knockout on intestinal microbiome composition and function. Extensive 16S rRNA sequencing revealed substantial changes in microbial diversity and specific taxonomic abundances, yet it did not affect the functional structure of the intestinal tissues. Notably, iNOS-deficient zebrafish demonstrated a decrease in Vibrio species and an increase in Aeromonas species, with more pronounced effects observed in double knockouts. Further transcriptomic analysis of the gut in double iNOS knockout zebrafish indicated significant alterations in immune-related and metabolic pathways, including the complement and PPAR signaling pathways. These findings underscore the crucial interplay between host genetics and gut microbiota, indicating that iNOS plays a key role in modulating the gut microbial ecology, host immune system, and metabolic responses. Full article
(This article belongs to the Special Issue Gut Microbiome in Health and Disease (2nd Edition))
23 pages, 5422 KiB  
Article
Effects of Combined Live Bifidobacterium, Lactobacillus, Enterococcus, and Bacillus Cereus Tablets on the Structure and Function of the Intestinal Flora in Rabbits Undergoing Hepatic Artery Infusion Chemotherapy
by Xiangdong Yan, Liuhui Bai, Jin Lv, Ping Qi, Xiaojing Song and Lei Zhang
Biology 2024, 13(5), 327; https://doi.org/10.3390/biology13050327 - 8 May 2024
Viewed by 515
Abstract
Few studies have explored the biological mechanism by which probiotics alleviate adverse reactions to chemotherapy drugs after local hepatic chemotherapy perfusion by regulating the intestinal flora. This study investigates the effects of Combined Live Bifidobacterium, Lactobacillus, Enterococcus, and Bacillus Cereus [...] Read more.
Few studies have explored the biological mechanism by which probiotics alleviate adverse reactions to chemotherapy drugs after local hepatic chemotherapy perfusion by regulating the intestinal flora. This study investigates the effects of Combined Live Bifidobacterium, Lactobacillus, Enterococcus, and Bacillus Cereus Tablets on the intestinal microbial structure and intestinal barrier function, as well as the potential mechanism in rabbits after local hepatic chemotherapy infusion. Eighteen New Zealand White rabbits were randomly divided into a control group, a hepatic local chemotherapy perfusion group, and a hepatic local chemotherapy perfusion + Combined Live Bifidobacterium, Lactobacillus, Enterococcus, and Bacillus Cereus Tablets group to assess the effects of Combined Live Bifidobacterium, Lactobacillus, Enterococcus, and Bacillus Cereus Tablets on the adverse reactions. The administration of Combined Live Bifidobacterium, Lactobacillus, Enterococcus, and Bacillus Cereus Tablets alleviated the intestinal flora disorder caused by local hepatic perfusion chemotherapy, promoted the growth of beneficial bacteria, and inhibited the growth of harmful bacteria. The Combined Live Bifidobacterium, Lactobacillus, Enterococcus, and Bacillus Cereus Tablets also reduced the levels of serum pro-inflammatory cytokines and liver injury factors induced by local hepatic perfusion chemotherapy. Our findings indicate that Combined Live Bifidobacterium, Lactobacillus, Enterococcus, and Bacillus Cereus Tablets can ameliorate the toxicity and side effects of chemotherapy by regulating intestinal flora, blocking pro-inflammatory cytokines, reducing liver injury factors, and repairing the intestinal barrier. Probiotics may be used as a potential alternative therapeutic strategy to prevent the adverse reactions caused by chemotherapy with local hepatic perfusion. Full article
(This article belongs to the Special Issue Gut Microbiome in Health and Disease (2nd Edition))
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Comparatives of probiotics materials on growth performance and gut microbiome in Broiler chickens between 7-and 35 days
Authors: Jin Young Jeong1,*; Minji Kim1; Yoo-Bhin Kim1; Jung Park2; Jaekyeong Song; Hwan Ku Kang1; Nam-Geon Park1
Affiliation: 1. Animal Nutrition and Physiology Division, National Institute of Animal Science, Wanju 55365, Korea
Abstract: Broiler cecal microbiota is an important for improving host health and its composition can be affected by various factors, such as diet, age, species, breed, regions, and environments. The objective of this study was to evaluate the impact of probiotics on cecal microbiota in broiler chicken at 7- and 35 d. The 16S rRNA gene amplicon sequencing of fecal microbiota was conducted from broiler divided into four groups: (1) control fed normal diet (2) B. subtilis (3) essential oil (4) B. velezensis. Firmicutes and Bacteroidota were the first and second most dominant phyla in all the samples, respectively. At the genus level, Romboutsia, Paeniclostridium, and Turicibacter were the most abundant in the B. substilis while Akkermansia, Bacteroides, and Monoglobus were the most abundant in the oregano oil group.

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