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Antibiotics, Volume 9, Issue 9

2020 September - 109 articles

Cover Story: To prevent and slow the spread of drug-resistant infections, antibiotics should only be prescribed when they are needed. Guidelines for treating acute dental conditions are based on the principle that operative dental procedures (extraction of a tooth or open drainage of its pulp chamber) are usually indicated to remove the cause of dental pain and/or infection. Antibiotics are only required for spreading infections. Internationally, dentists are estimated to be responsible for 10% of all antibiotics prescribed to humans and the rates of overprescribing are high. To inform the development of new approaches to dental antibiotic stewardship, this ethnographic study investigated dentist and patient factors influencing treatment decisions (including antibiotic prescribing) for adults presenting with acute conditions in out-of-hours and general dental practices of the NHS in England. View this paper.
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Articles (109)

  • Article
  • Open Access
24 Citations
5,590 Views
16 Pages

Exploration of Chemical Diversity and Antitrypanosomal Activity of Some Red Sea-Derived Actinomycetes Using the OSMAC Approach Supported by LC-MS-Based Metabolomics and Molecular Modelling

  • Noha M. Gamaleldin,
  • Walid Bakeer,
  • Ahmed M. Sayed,
  • Yara I. Shamikh,
  • Ahmed O. El-Gendy,
  • Hossam M. Hassan,
  • Hannes Horn,
  • Usama Ramadan Abdelmohsen and
  • Wael N. Hozzein

22 September 2020

In the present study, we investigated the actinomycetes associated with the Red Sea-derived soft coral Sarcophyton glaucum in terms of biological and chemical diversity. Three strains were cultivated and identified to be members of genera Micromonosp...

  • Article
  • Open Access
61 Citations
5,990 Views
11 Pages

22 September 2020

Monitoring of pathogen resistance profiles is necessary to guide empirical antibiotic therapy before culture and sensitivity results become available. The aim of this study was to describe current antibiotic resistance patterns of five most frequent...

  • Article
  • Open Access
9 Citations
3,944 Views
14 Pages

Antimicrobial Resistance, an Update from the Ward: Increased Incidence of New Potential Pathogens and Site of Infection-Specific Antibacterial Resistances

  • Irene Stefanini,
  • Martina Boni,
  • Paola Silvaplana,
  • Paola Lovera,
  • Stefania Pelassa,
  • Giuseppe De Renzi and
  • Barbara Mognetti

22 September 2020

In order to monitor the spread of antimicrobial resistance, the European Union requires hospitals to be equipped with infection control centers. With this aim, we analyzed 1583 bacterial strains isolated from samples of different origin from patients...

  • Review
  • Open Access
61 Citations
9,092 Views
18 Pages

Treatment of Bloodstream Infections Due to Gram-Negative Bacteria with Difficult-to-Treat Resistance

  • Matteo Bassetti,
  • Antonio Vena,
  • Chiara Sepulcri,
  • Daniele Roberto Giacobbe and
  • Maddalena Peghin

22 September 2020

The rising incidence of bloodstream infections (BSI) due to Gram-negative bacteria (GNB) with difficult-to-treat resistance (DTR) has been recognized as a global emergency. The aim of this review is to provide a comprehensive assessment of the mechan...

  • Article
  • Open Access
26 Citations
8,532 Views
22 Pages

Repurposing Disulfiram (Tetraethylthiuram Disulfide) as a Potential Drug Candidate against Borrelia burgdorferi In Vitro and In Vivo

  • Hari-Hara S. K. Potula,
  • Jahanbanoo Shahryari,
  • Mohammed Inayathullah,
  • Andrey Victorovich Malkovskiy,
  • Kwang-Min Kim and
  • Jayakumar Rajadas

22 September 2020

Lyme disease caused by the Borrelia burgdorferi (Bb or B. burgdorferi) is the most common vector-borne, multi-systemic disease in the USA. Although most Lyme disease patients can be cured with a course of the first line of antibiotic treatment, some...

  • Article
  • Open Access
10 Citations
4,791 Views
12 Pages

Comparison of Three Endodontic Irrigant Regimens against Dual-Species Interkingdom Biofilms: Considerations for Maintaining the Status Quo

  • Om Alkhir Alshanta,
  • Saeed Alqahtani,
  • Suror Shaban,
  • Khawlah Albashaireh,
  • William McLean and
  • Gordon Ramage

22 September 2020

Endodontic infections are often interkingdom biofilms, though current clinical management rarely considers this phenomenon. This study aimed to evaluate new and standard endodontic antimicrobial regimens against simple and complex Candida albicans an...

  • Article
  • Open Access
22 Citations
4,625 Views
14 Pages

Figainin 1, a Novel Amphibian Skin Peptide with Antimicrobial and Antiproliferative Properties

  • Carlos José Correia Santana,
  • Ana Carolina Martins Magalhães,
  • Agenor C. M. dos Santos Júnior,
  • Carlos André Ornelas Ricart,
  • Beatriz D. Lima,
  • Alice da Cunha Morales Álvares,
  • Sonia Maria de Freitas,
  • Osmindo Rodrigues Pires,
  • Wagner Fontes and
  • Mariana S. Castro

21 September 2020

Amphibian skin secretions are abundant in bioactive compounds, especially antimicrobial peptides. These molecules are generally cationic and rich in hydrophobic amino acids, have an amphipathic structure and adopt an α-helical conformation when...

  • Article
  • Open Access
6 Citations
3,263 Views
15 Pages

Clinical Significance of Carbapenem-Tolerant Pseudomonas aeruginosa Isolated in the Respiratory Tract

  • Momoyo Azuma,
  • Keiji Murakami,
  • Rina Murata,
  • Keiko Kataoka,
  • Hideki Fujii,
  • Yoichiro Miyake and
  • Yasuhiko Nishioka

21 September 2020

We often come across difficult to treat infections—even after administering appropriate antibiotics according to the minimal inhibitory concentration of the causative bacteria. Antibiotic tolerance has recently started to garner attention as a...

  • Article
  • Open Access
25 Citations
4,610 Views
19 Pages

Broad-Spectrum Antimicrobial Activity and Improved Stability of a D-Amino Acid Enantiomer of DMPC-10A, the Designed Derivative of Dermaseptin Truncates

  • Yu Zai,
  • Yuan Ying,
  • Zhuming Ye,
  • Mei Zhou,
  • Chengbang Ma,
  • Zhanzhong Shi,
  • Xiaoling Chen,
  • Xinping Xi,
  • Tianbao Chen and
  • Lei Wang

21 September 2020

DMPC-10A (ALWKKLLKK-Cha-NH2) is a 10-mer peptide derivative from the N-terminal domain of Dermaseptin-PC which has shown broad-spectrum antimicrobial activity as well as a considerable hemolytic effect. In order to reduce hemolytic activity and impro...

  • Article
  • Open Access
29 Citations
5,973 Views
16 Pages

21 September 2020

Clavibacter michiganensis subsp. michiganensis (Smith) Davis et al. (Cmm) and Ralstonia solanacearum Yabuuchi et al. (Smith) (Rs) are important seed-borne bacterial pathogens of tomato (Solanum lycopersicum) listed as A2 pests in the EPPO (European a...

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Antibiotics - ISSN 2079-6382