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Antibiotics, Volume 9, Issue 8

August 2020 - 94 articles

Cover Story: The Earth’s immense oceans are home to a great diversity of biological resources, including copious microorganisms like bacteria that are, still, very much underexplored. In this work, we discuss how some of the greatest health challenges faced by humans, such as the rise of antibiotic resistance in bacteria, pathogenic fungi and parasites, cancer incidence, and viral infection outbreaks, can be tackled by studying the bacteria found in oceans. Moreover, we give an overview of the research pipeline of novel molecules, from the identification of bioactive bacterial crude extracts to the isolation and chemical characterization of the molecules within the framework of the One Health approach. This work demonstrates the current relevance of marine bacteria for the discovery of novel bioactive natural products. View this paper.
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Articles (94)

  • Article
  • Open Access
8 Citations
5,209 Views
9 Pages

According to the Guidelines of the European Society of Pediatric Infectious Diseases (ESPID), in low methicillin-resistant Staphylococcus aureus (MRSA) prevalence settings, short intravenous therapy is recommended in uncomplicated cases of acute haem...

  • Review
  • Open Access
34 Citations
14,996 Views
19 Pages

Actinomycosis is a chronic, suppurative, granulomatous infectious disease, caused by different species of Actinomyces bacteria. To date, 26 validly published Actinomyces species have been described as part of a normal human microbiota or from human c...

  • Article
  • Open Access
29 Citations
8,843 Views
11 Pages

Rapid Antibacterial Activity of Cannabichromenic Acid against Methicillin-Resistant Staphylococcus aureus

  • Maria Galletta,
  • Tristan A. Reekie,
  • Gayathri Nagalingam,
  • Amy L. Bottomley,
  • Elizabeth J. Harry,
  • Michael Kassiou and
  • James A. Triccas

Methicillin-resistant Staphylococcus aureus (MRSA) has proven to be an imminent threat to public health, intensifying the need for novel therapeutics. Previous evidence suggests that cannabinoids harbour potent antibacterial activity. In this study,...

  • Article
  • Open Access
12 Citations
4,828 Views
16 Pages

Enzybiotics LYSSTAPH-S and LYSDERM-S as Potential Therapeutic Agents for Chronic MRSA Wound Infections

  • Lukáš Vacek,
  • Šárka Kobzová,
  • Richard Čmelík,
  • Roman Pantůček and
  • Lubomír Janda

Antibacterial antibiotic therapy has played an important role in the treatment of bacterial infections for almost a century. The increasing resistance of pathogenic bacteria to antibiotics leads to an attempt to use previously neglected antibacterial...

  • Article
  • Open Access
5 Citations
4,969 Views
10 Pages

Strain-Specific Adaptations of Streptococcus mitis-oralis to Serial In Vitro Passage in Daptomycin (DAP): Genotypic and Phenotypic Characteristics

  • Nagendra N. Mishra,
  • Truc T. Tran,
  • Cesar A. Arias,
  • Ravin Seepersaud,
  • Paul M. Sullam and
  • Arnold S. Bayer

Viridans group streptococci (VGS), especially the Streptococcus mitis-oralis subgroup, are pivotal pathogens in a variety of invasive endovascular infections, including “toxic shock” in neutropenic cancer patients and infective endocardit...

  • Article
  • Open Access
1 Citations
4,095 Views
22 Pages

Effectiveness of Electronic Guidelines (GERH®) to Improve the Clinical Use of Antibiotics in An Intensive Care Unit

  • Paola Navarro-Gómez,
  • Jose Gutierrez-Fernandez,
  • Manuel Angel Rodriguez-Maresca,
  • Maria Carmen Olvera-Porcel and
  • Antonio Sorlozano-Puerto

The objective of the study was to evaluate the capacity of GERH®-derived local resistance maps (LRMs) to predict antibiotic susceptibility profiles and recommend the appropriate empirical treatment for ICU patients with nosocomial infection. Data...

  • Review
  • Open Access
15 Citations
4,640 Views
14 Pages

Tissue engineering is one of the most important biotechnologies in the biomedical field. It requires the application of the principles of scientific engineering in order to design and build natural or synthetic biomaterials feasible for the maintenan...

  • Article
  • Open Access
8 Citations
4,206 Views
11 Pages

A Trypsin Inhibitor from Moringa oleifera Flowers Modulates the Immune Response In Vitro of Trypanosoma cruzi-Infected Human Cells

  • Isabella Coimbra Vila Nova,
  • Leyllane Rafael Moreira,
  • Diego José Lira Torres,
  • Kamila Kássia dos Santos Oliveira,
  • Leydianne Leite de Siqueira Patriota,
  • Luana Cassandra Breitenbach Barroso Coelho,
  • Patrícia Maria Guedes Paiva,
  • Thiago Henrique Napoleão,
  • Virgínia Maria Barros de Lorena and
  • Emmanuel Viana Pontual

Trypanosoma cruzi causes the lethal Chagas disease, which is endemic in Latin America. Flowers of Moringa oleifera (Moringaceae) express a trypsin inhibitor (MoFTI) whose toxicity to T. cruzi trypomastigotes was previously reported. Here, we studied...

  • Article
  • Open Access
10 Citations
5,078 Views
10 Pages

In Vitro Activities of Colistin and Sitafloxacin Combinations against Multidrug-, Carbapenem-, and Colistin-Resistant Acinetobacter baumannii Using the Broth Microdilution Checkerboard and Time-Kill Methods

  • Vipavee Rodjun,
  • Jantana Houngsaitong,
  • Preecha Montakantikul,
  • Taniya Paiboonvong,
  • Piyatip Khuntayaporn,
  • Pattareeya Yanyongchaikit and
  • Pusana Sriyant

Drug-resistant Acinetobacter baumannii (A. baumannii) infections are a critical global problem, with limited treatment choices. This study aims to determine the in vitro activities of colistin–sitafloxacin combinations against multidrug-, carba...

  • Article
  • Open Access
24 Citations
6,920 Views
18 Pages

Melittin from Apis florea Venom as a Promising Therapeutic Agent for Skin Cancer Treatment

  • Sirikwan Sangboonruang,
  • Kuntida Kitidee,
  • Panuwan Chantawannakul,
  • Khajornsak Tragoolpua and
  • Yingmanee Tragoolpua

Melittin, a major component found in bee venom, is produced by the Apis species of the honey bee. In this study, the effect of melittin derived from Apis florea (Mel-AF), which is a wild honey bee species that is indigenous to Thailand, was investiga...

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Antibiotics - ISSN 2079-6382