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Synergies with and Resistance to Membrane-Active Peptides

Department of Chemistry and Biochemistry, Seton Hall University, South Orange, NJ 07079, USA
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Antibiotics 2020, 9(9), 620; https://doi.org/10.3390/antibiotics9090620
Received: 24 August 2020 / Revised: 7 September 2020 / Accepted: 17 September 2020 / Published: 19 September 2020
(This article belongs to the Special Issue Synthesis and Utility of Antimicrobial Peptides)
Membrane-active peptides (MAPs) have long been thought of as the key to defeating antimicrobial-resistant microorganisms. Such peptides, however, may not be sufficient alone. In this review, we seek to highlight some of the common pathways for resistance, as well as some avenues for potential synergy. This discussion takes place considering resistance, and/or synergy in the extracellular space, at the membrane, and during interaction, and/or removal. Overall, this review shows that researchers require improved definitions of resistance and a more thorough understanding of MAP-resistance mechanisms. The solution to combating resistance may ultimately come from an understanding of how to harness the power of synergistic drug combinations. View Full-Text
Keywords: membrane-active peptides; antimicrobial-resistance; drug synergy membrane-active peptides; antimicrobial-resistance; drug synergy
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Kmeck, A.; Tancer, R.J.; Ventura, C.R.; Wiedman, G.R. Synergies with and Resistance to Membrane-Active Peptides. Antibiotics 2020, 9, 620.

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