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Antibiotics, Volume 9, Issue 10

October 2020 - 89 articles

Cover Story: Tailed bacteriophages, the most common type of phages used in antibacterial therapy, are much more diverse than originally thought based on their morphology. In this paper, we use a combination of genomic, proteomic and phylogenetic approaches to delineate a new family of phages related to Escherichia phage N4, a short-tailed phage with a characteristic large virion-associated RNA polymerase. The new family is tentatively named “Schitoviridae” after the discoverer of phage N4, comprises 115 analysed genomes and is proposed to be divided into eight subfamilies and numerous new genera. The cover image shows a gene-sharing network of schitoviruses and other bacteriophages on the left and a virus proteomic tree of selected podoviruses on the right, on a background of N4 TEM copies (TEM donated to A Kropinski by HW Ackermann). View this paper.
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Articles (89)

  • Article
  • Open Access
3 Citations
3,819 Views
14 Pages

Effect of Fosfomycin on Cyclosporine Nephrotoxicity

  • Juan Antonio Ortega-Trejo,
  • Rosalba Pérez-Villalva,
  • José M. Arreola-Guerra,
  • Victoria Ramírez,
  • José Sifuentes-Osornio and
  • Norma A Bobadilla

Fosfomycin (Fos) has emerged as a potential treatment against multidrug-resistant organisms, however, there has been little work done on its influence on calcineurin inhibitor nephrotoxicity (CIN). This study was designed to evaluate the effect of Fo...

  • Article
  • Open Access
42 Citations
6,221 Views
17 Pages

Antibiotic Adsorption by Metal-Organic Framework (UiO-66): A Comprehensive Kinetic, Thermodynamic, and Mechanistic Study

  • Mossab K. Alsaedi,
  • Ghada K. Alothman,
  • Mohammed N. Alnajrani,
  • Omar A. Alsager,
  • Sultan A. Alshmimri,
  • Majed A. Alharbi,
  • Majed O. Alawad,
  • Shahad Alhadlaq and
  • Seetah Alharbi

Bacterial antibiotic resistance has been deemed one of the largest modern threats to human health. One of the root causes of antibiotic resistance is the inability of traditional wastewater management techniques, such as filtration and disinfection,...

  • Article
  • Open Access
23 Citations
3,278 Views
8 Pages

Helicobacter pylori Primary and Secondary Genotypic Resistance to Clarithromycin and Levofloxacin Detection in Stools: A 4-Year Scenario in Southern Italy

  • Giuseppe Losurdo,
  • Floriana Giorgio,
  • Maria Pricci,
  • Bruna Girardi,
  • Francesco Russo,
  • Giuseppe Riezzo,
  • Manuela Martulli,
  • Mariano Piazzolla,
  • Francesco Cocomazzi and
  • Francesco Abbruzzi
  • + 7 authors

Antibiotic resistance has become an emerging problem for treating Helicobacter pylori (H. pylori) infection. Clarithromycin and levofloxacin are two key antibiotics used for its eradication. Therefore, we reviewed our experience with genotypic resist...

  • Review
  • Open Access
105 Citations
7,387 Views
13 Pages

Titanium (Ti) and its alloys are commonly used in medical devices. However, biomaterial-associated infections such as peri-implantitis and prosthetic joint infections are devastating and threatening complications for patients, dentists, and orthopedi...

  • Article
  • Open Access
35 Citations
7,717 Views
17 Pages

Antibacterial and Cytotoxic Activities of Ten Commercially Available Essential Oils

  • Sofia Oliveira Ribeiro,
  • Véronique Fontaine,
  • Véronique Mathieu,
  • Abdesselam Zhiri,
  • Dominique Baudoux,
  • Caroline Stévigny and
  • Florence Souard

There is a huge concern in the medical field concerning the emergence of bacterial resistance to antibiotics. Essential oils are a source of antibacterial compounds that can overcome this problem. Ten essential oils that are commercially available we...

  • Article
  • Open Access
14 Citations
4,436 Views
15 Pages

Peptidomic Analysis of Skin Secretions of the Caribbean Frogs Leptodactylus insularum and Leptodactylus nesiotus (Leptodactylidae) Identifies an Ocellatin with Broad Spectrum Antimicrobial Activity

  • Gervonne Barran,
  • Jolanta Kolodziejek,
  • Laurent Coquet,
  • Jérôme Leprince,
  • Thierry Jouenne,
  • Norbert Nowotny,
  • J. Michael Conlon and
  • Milena Mechkarska

Ocellatins are peptides produced in the skins of frogs belonging to the genus Leptodactylus that generally display weak antimicrobial activity against Gram-negative bacteria only. Peptidomic analysis of norepinephrine-stimulated skin secretions from...

  • Feature Paper
  • Review
  • Open Access
84 Citations
7,518 Views
11 Pages

Bacteria present in the human body are innocuous, providing beneficial functions, some of which are necessary for correct body function. However, other bacteria are able to colonize, invade, and cause damage to different tissues, and these are catego...

  • Letter
  • Open Access
29 Citations
4,522 Views
6 Pages

Aminoglycoside Antibiotics Inhibit Mycobacteriophage Infection

  • Zheng Jiang,
  • Junwei Wei,
  • Yunxiang Liang,
  • Nan Peng and
  • Yingjun Li

Antibiotic resistance is becoming the biggest threat to global health. At the same time, phage therapy is witnessing a return of interest. The therapeutic use of bacteriophages that infect and kill bacteria is a suitable strategy to combat antibiotic...

  • Article
  • Open Access
3 Citations
3,546 Views
15 Pages

Aureolic Acid Group of Agents as Potential Antituberculosis Drugs

  • Julia Bespyatykh,
  • Dmitry Bespiatykh,
  • Maja Malakhova,
  • Ksenia Klimina,
  • Andrey Bespyatykh,
  • Anna Varizhuk,
  • Anna Tevyashova,
  • Tatiana Nikolenko,
  • Galina Pozmogova and
  • Elena Ilina
  • + 1 author

Mycobacterium tuberculosis is one of the most dangerous pathogens. Bacterial resistance to antituberculosis drugs grows each year, but searching for new drugs is a long process. Testing for available drugs to find active against mycobacteria may be a...

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Antibiotics - ISSN 2079-6382Creative Common CC BY license