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Antibiotics, Volume 9, Issue 8

August 2020 - 94 articles

Cover Story: The Earth’s immense oceans are home to a great diversity of biological resources, including copious microorganisms like bacteria that are, still, very much underexplored. In this work, we discuss how some of the greatest health challenges faced by humans, such as the rise of antibiotic resistance in bacteria, pathogenic fungi and parasites, cancer incidence, and viral infection outbreaks, can be tackled by studying the bacteria found in oceans. Moreover, we give an overview of the research pipeline of novel molecules, from the identification of bioactive bacterial crude extracts to the isolation and chemical characterization of the molecules within the framework of the One Health approach. This work demonstrates the current relevance of marine bacteria for the discovery of novel bioactive natural products. View this paper.
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Articles (94)

  • Communication
  • Open Access
16 Citations
3,823 Views
9 Pages

Potent Antibacterial Prenylated Acetophenones from the Australian Endemic Plant Acronychia crassipetala

  • Trong D. Tran,
  • Malin A. Olsson,
  • David J. McMillan,
  • Jason K. Cullen,
  • Peter G. Parsons,
  • Paul W. Reddell and
  • Steven M. Ogbourne

Acronychia crassipetala is an endemic plant species in Australia. Its phytochemistry and therapeutic properties are underexplored. The hexane extract of the fruit A. crassipetala T. G. Hartley was found to inhibit the growth of the Gram-positive bact...

  • Article
  • Open Access
21 Citations
5,053 Views
12 Pages

Impact of Colistin Dosing on the Incidence of Nephrotoxicity in a Tertiary Care Hospital in Saudi Arabia

  • Reem Almutairy,
  • Waad Aljrarri,
  • Afnan Noor,
  • Pansy Elsamadisi,
  • Nour Shamas,
  • Mohammad Qureshi and
  • Sherine Ismail

Colistin therapy is associated with the development of nephrotoxicity. We examined the incidence and risk factors of nephrotoxicity associated with colistin dosing. We included adult hospitalized patients who received intravenous (IV) colistin for &g...

  • Case Report
  • Open Access
3 Citations
3,833 Views
6 Pages

Mycobacterium szulgai Lung Disease or Breast Cancer Relapse—Case Report

  • Anna Kempisty,
  • Ewa Augustynowicz-Kopec,
  • Lucyna Opoka and
  • Monika Szturmowicz

Cancers are one of the risk factors of non-tuberculous mycobacterial (NTM) lung disease. The majority of data in this group of patients concern infections caused by Mycobacterium avium—the most prevalent NTM species worldwide. In contrast, limi...

  • Article
  • Open Access
6 Citations
3,688 Views
10 Pages

N-Acylhomoserine lactones (AHLs) are used as quorum-sensing signals in Gram-negative bacteria. Many genes encoding AHL-degrading enzymes have been cloned and characterized in various microorganisms. Coagulase-negative staphylococci (CNS) are present...

  • Article
  • Open Access
14 Citations
3,887 Views
11 Pages

Risk of Antimicrobial Resistant Non-Typhoidal Salmonella during Asymptomatic Infection Passage between Pet Dogs and Their Human Caregivers in Khon Kaen, Thailand

  • Xin Wu,
  • Sunpetch Angkititrakul,
  • Allen L. Richards,
  • Chaiwat Pulsrikarn,
  • Seri Khaengair,
  • Amphone Keosengthong,
  • Supatcharee Siriwong and
  • Fanan Suksawat

To explore the risk of antimicrobial resistant (AMR) non-typhoidal Salmonella during asymptomatic infection passage between pet dogs and human caregivers in Khon Kaen, Thailand, one hundred forty paired fecal samples (n = 280) were obtained from comp...

  • Article
  • Open Access
44 Citations
7,066 Views
20 Pages

Lactobacillus Plantarum 108 Inhibits Streptococcus mutans and Candida albicans Mixed-Species Biofilm Formation

  • Neha Srivastava,
  • Kassapa Ellepola,
  • Nityasri Venkiteswaran,
  • Louis Yi Ann Chai,
  • Tomoko Ohshima and
  • Chaminda Jayampath Seneviratne

Streptococcus mutans is the principal biofilm forming oral pathogen associated with dental caries. Studies have shown that Candida albicans, a commensal oral fungus is capable of forming pathogenic mixed-species biofilms with S. mutans. The treatment...

  • Communication
  • Open Access
6 Citations
3,231 Views
7 Pages

Antimicrobial Resistance Patterns in Clostridioides difficile Strains Isolated from Neonates in Germany

  • Friederike K. M. T. Tilkorn,
  • Hagen Frickmann,
  • Isabel S. Simon,
  • Julian Schwanbeck,
  • Sebastian Horn,
  • Ortrud Zimmermann,
  • Uwe Groß,
  • Wolfgang Bohne and
  • Andreas E. Zautner

Young children are frequently colonized with Clostridioides (C.) difficile. Depending on their resistance patterns, antibiotic treatment can facilitate gastrointestinal spreading in colonized individuals, potentially leading to transmission to others...

  • Article
  • Open Access
9 Citations
3,636 Views
20 Pages

Analysing the Relationship between Nutrition and the Microbial Composition of the Oral Biofilm—Insights from the Analysis of Individual Variability

  • Kirstin Vach,
  • Ali Al-Ahmad,
  • Annette Anderson,
  • Johan Peter Woelber,
  • Lamprini Karygianni,
  • Annette Wittmer and
  • Elmar Hellwig

The influence of a change in nutrition on the oral microbiota are discussed in literature, but usually only changes of population mean values are reported. This paper introduces simple methods to also analyse and report the variability of patients&rs...

  • Review
  • Open Access
226 Citations
18,676 Views
23 Pages

Plant-Based Phytochemicals as Possible Alternative to Antibiotics in Combating Bacterial Drug Resistance

  • Hana Mohammed Al AlSheikh,
  • Insha Sultan,
  • Vijay Kumar,
  • Irfan A. Rather,
  • Hashem Al-Sheikh,
  • Arif Tasleem Jan and
  • Qazi Mohd Rizwanul Haq

The unprecedented use of antibiotics that led to development of resistance affect human health worldwide. Prescription of antibiotics imprudently and irrationally in different diseases progressed with the acquisition and as such development of antibi...

  • Article
  • Open Access
5 Citations
3,697 Views
16 Pages

Contact Effect of a Methylobacterium sp. Extract on Biofilm of a Mycobacterium chimaera Strain Isolated from a 3T Heater-Cooler System

  • Inés Pradal,
  • Jaime Esteban,
  • Arancha Mediero,
  • Marta García-Coca and
  • John Jairo Aguilera-Correa

Mycobacterium chimaera is an opportunistic slowly growing non-tuberculous mycobacteriumof increasing importance due to the outbreak of cases associated with contaminated 3T heater-cooler device (HCD) extracorporeal membrane oxygenator (ECMO). The aim...

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Antibiotics - ISSN 2079-6382