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Antibiotics, Volume 9, Issue 8

August 2020 - 94 articles

Cover Story: The Earth’s immense oceans are home to a great diversity of biological resources, including copious microorganisms like bacteria that are, still, very much underexplored. In this work, we discuss how some of the greatest health challenges faced by humans, such as the rise of antibiotic resistance in bacteria, pathogenic fungi and parasites, cancer incidence, and viral infection outbreaks, can be tackled by studying the bacteria found in oceans. Moreover, we give an overview of the research pipeline of novel molecules, from the identification of bioactive bacterial crude extracts to the isolation and chemical characterization of the molecules within the framework of the One Health approach. This work demonstrates the current relevance of marine bacteria for the discovery of novel bioactive natural products. View this paper.
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Articles (94)

  • Review
  • Open Access
102 Citations
10,774 Views
12 Pages

Antibiotic Use in Low and Middle-Income Countries and the Challenges of Antimicrobial Resistance in Surgery

  • Massimo Sartelli,
  • Timothy C. Hardcastle,
  • Fausto Catena,
  • Alain Chichom-Mefire,
  • Federico Coccolini,
  • Sameer Dhingra,
  • Mainul Haque,
  • Adrien Hodonou,
  • Katia Iskandar and
  • Francesco M. Labricciosa
  • + 3 authors

Antimicrobial resistance (AMR) is a phenomenon resulting from the natural evolution of microbes. Nonetheless, human activities accelerate the pace at which microorganisms develop and spread resistance. AMR is a complex and multidimensional problem, t...

  • Review
  • Open Access
37 Citations
11,537 Views
31 Pages

The first antibiotic-producing actinomycete (Streptomyces antibioticus) was described by Waksman and Woodruff in 1940. This discovery initiated the “actinomycetes era”, in which several species were identified and demonstrated to be a gre...

  • Article
  • Open Access
59 Citations
5,917 Views
10 Pages

Active Pulmonary Tuberculosis in Elderly Patients: A 2016–2019 Retrospective Analysis from an Italian Referral Hospital

  • Francesco Di Gennaro,
  • Pietro Vittozzi,
  • Gina Gualano,
  • Maria Musso,
  • Silvia Mosti,
  • Paola Mencarini,
  • Carlo Pareo,
  • Antonino Di Caro,
  • Vincenzo Schininà and
  • Enrico Girardi
  • + 1 author

Tuberculosis (TB) in the elderly (>65 years old) has increasingly become a global health problem. It has long been recognized that older people are vulnerable to developing tuberculosis. We retrospectively evaluated data from patients older than 6...

  • Article
  • Open Access
2 Citations
5,346 Views
14 Pages

Prescriber Commitment Posters to Increase Prudent Antibiotic Prescribing in English General Practice: A Cluster Randomized Controlled Trial

  • Anna Sallis,
  • Paulina Bondaronek,
  • Jet G. Sanders,
  • Ly-Mee Yu,
  • Victoria Harris,
  • Ivo Vlaev,
  • Michael Sanders,
  • Sarah Tonkin-Crine and
  • Tim Chadborn

Unnecessary antibiotic prescribing contributes to Antimicrobial Resistance posing a major public health risk. Estimates suggest as many as half of antibiotics prescribed for respiratory infections may be unnecessary. We conducted a three-armed unblin...

  • Article
  • Open Access
52 Citations
7,669 Views
26 Pages

Amphibians are widely distributed on different continents, except for the polar regions. They are important sources for the isolation, purification and characterization of natural compounds, including peptides with various functions. Innate immune an...

  • Article
  • Open Access
10 Citations
4,633 Views
14 Pages

There are concerns that general dentists (GDs) and dental specialists may be prescribing antibiotics inappropriately. This study explored the prescribing habits and decision-making processes of GDs versus oral and maxillofacial surgeons (OMFSs). A ca...

  • Review
  • Open Access
83 Citations
11,588 Views
30 Pages

A Hundred Years of Bacteriophages: Can Phages Replace Antibiotics in Agriculture and Aquaculture?

  • Carmen Sieiro,
  • Lara Areal-Hermida,
  • Ángeles Pichardo-Gallardo,
  • Raquel Almuiña-González,
  • Trinidad de Miguel,
  • Sandra Sánchez,
  • Ángeles Sánchez-Pérez and
  • Tomás G. Villa

Agriculture, together with aquaculture, supplies most of the foodstuffs required by the world human population to survive. Hence, bacterial diseases affecting either agricultural crops, fish, or shellfish not only cause large economic losses to produ...

  • Perspective
  • Open Access
19 Citations
6,162 Views
13 Pages

Antibiotics have changed human health and revolutionised medical practice since the Second World War. Today, the use of antibiotics is increasingly limited by the rise of antimicrobial-resistant strains. Additionally, broad-spectrum antibiotic activi...

  • Review
  • Open Access
27 Citations
6,578 Views
13 Pages

Acute bone and joint infections (BJIs) in children may clinically occur as osteomyelitis (OM) or septic arthritis (SA). In clinical practice, one-third of cases present a combination of both conditions. BJIs are usually caused by the haematogenous di...

  • Article
  • Open Access
7 Citations
3,864 Views
16 Pages

Synthesis of Degraded Limonoid Analogs as New Antibacterial Scaffolds against Staphylococcus aureus

  • Marta Ferrera-Suanzes,
  • Victoria Prieto,
  • Antonio J. Medina-Olivera,
  • José Manuel Botubol-Ares,
  • Fátima Galán-Sánchez,
  • Manuel A. Rodríguez-Iglesias,
  • Rosario Hernández-Galán and
  • María Jesús Durán-Peña

Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA) have become serious infections in humans and ruminants. S. aureus strains are showing rapid changes to develop resistance in traditional antibiotic-containing systems. In th...

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Antibiotics - ISSN 2079-6382