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Review

Plant-Based Phytochemicals as Possible Alternative to Antibiotics in Combating Bacterial Drug Resistance

1
Department of Prosthetic Dental Sciences, College of Dentistry, Kind Saud University, Riyadh P.O. BOX 145111, Saudi Arabia
2
Department of Biosciences, Jamia Millia Islamia, New Delhi 110025, India
3
Department of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk 38541, Korea
4
Department of Biological Sciences, Faculty of Science, King Abdul Aziz University, Jeddah P.O. BOX 80200, Saudi Arabia
5
Department of Biological Sciences, College of Science, King Faisal University, Al-Ahsa 31982, Saudi Arabia
6
School of Biosciences and Biotechnology, Baba Ghulam Shah Badshah University, Rajouri 185234, India
*
Authors to whom correspondence should be addressed.
These authors contributed equally to the writing of the manuscript.
Antibiotics 2020, 9(8), 480; https://doi.org/10.3390/antibiotics9080480
Received: 25 June 2020 / Revised: 26 July 2020 / Accepted: 1 August 2020 / Published: 4 August 2020
The unprecedented use of antibiotics that led to development of resistance affect human health worldwide. Prescription of antibiotics imprudently and irrationally in different diseases progressed with the acquisition and as such development of antibiotic resistant microbes that led to the resurgence of pathogenic strains harboring enhanced armors against existing therapeutics. Compromised the treatment regime of a broad range of antibiotics, rise in resistance has threatened human health and increased the treatment cost of diseases. Diverse on metabolic, genetic and physiological fronts, rapid progression of resistant microbes and the lack of a strategic management plan have led researchers to consider plant-derived substances (PDS) as alternative or in complementing antibiotics against the diseases. Considering the quantitative characteristics of plant constituents that attribute health beneficial effects, analytical procedures for their isolation, characterization and phytochemical testing for elucidating ethnopharmacological effects has being worked out for employment in the treatment of different diseases. With an immense potential to combat bacterial infections, PDSs such as polyphenols, alkaloids and tannins, present a great potential for use, either as antimicrobials or as antibiotic resistance modifiers. The present study focuses on the mechanisms by which PDSs help overcome the surge in resistance, approaches for screening different phytochemicals, methods employed in the identification of bioactive components and their testing and strategies that could be adopted for counteracting the lethal consequences of multidrug resistance. View Full-Text
Keywords: antibiotics; bacteria; human health; plant-derived substances; resistance antibiotics; bacteria; human health; plant-derived substances; resistance
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MDPI and ACS Style

AlSheikh, H.M.A.; Sultan, I.; Kumar, V.; Rather, I.A.; Al-Sheikh, H.; Tasleem Jan, A.; Haq, Q.M.R. Plant-Based Phytochemicals as Possible Alternative to Antibiotics in Combating Bacterial Drug Resistance. Antibiotics 2020, 9, 480. https://doi.org/10.3390/antibiotics9080480

AMA Style

AlSheikh HMA, Sultan I, Kumar V, Rather IA, Al-Sheikh H, Tasleem Jan A, Haq QMR. Plant-Based Phytochemicals as Possible Alternative to Antibiotics in Combating Bacterial Drug Resistance. Antibiotics. 2020; 9(8):480. https://doi.org/10.3390/antibiotics9080480

Chicago/Turabian Style

AlSheikh, Hana M.A., Insha Sultan, Vijay Kumar, Irfan A. Rather, Hashem Al-Sheikh, Arif Tasleem Jan, and Qazi M.R. Haq 2020. "Plant-Based Phytochemicals as Possible Alternative to Antibiotics in Combating Bacterial Drug Resistance" Antibiotics 9, no. 8: 480. https://doi.org/10.3390/antibiotics9080480

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