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Review

From Ocean to Medicine: Pharmaceutical Applications of Metabolites from Marine Bacteria

1
Department of Biology, Faculty of Sciences, University of Porto, Rua do Campo Alegre s/n, 4169-007 Porto, Portugal
2
Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Terminal de Cruzeiros do Porto de Leixões, Avenida General Norton de Matos, S/N, 4450-208 Matosinhos, Portugal
3
Fundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Avenida del Conocimiento, 34 Parque Tecnológico de Ciencias de la Salud, 18016 Granada, Spain
*
Author to whom correspondence should be addressed.
Antibiotics 2020, 9(8), 455; https://doi.org/10.3390/antibiotics9080455
Received: 25 June 2020 / Revised: 17 July 2020 / Accepted: 25 July 2020 / Published: 28 July 2020
Oceans cover seventy percent of the planet’s surface and besides being an immense reservoir of biological life, they serve as vital sources for human sustenance, tourism, transport and commerce. Yet, it is estimated by the National Oceanic and Atmospheric Administration (NOAA) that eighty percent of the oceans remain unexplored. The untapped biological resources present in oceans may be fundamental in solving several of the world’s public health crises of the 21st century, which span from the rise of antibiotic resistance in bacteria, pathogenic fungi and parasites, to the rise of cancer incidence and viral infection outbreaks. In this review, health risks as well as how marine bacterial derived natural products may be tools to fight them will be discussed. Moreover, an overview will be made of the research pipeline of novel molecules, from identification of bioactive bacterial crude extracts to the isolation and chemical characterization of the molecules within the framework of the One Health approach. This review highlights information that has been published since 2014, showing the current relevance of marine bacteria for the discovery of novel natural products. View Full-Text
Keywords: marine natural products; antimicrobials; antivirals; anticancer; drug discovery; bioactive marine bacteria; antimicrobial resistance; cancer incidence; One Health marine natural products; antimicrobials; antivirals; anticancer; drug discovery; bioactive marine bacteria; antimicrobial resistance; cancer incidence; One Health
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MDPI and ACS Style

Santos, J.D.; Vitorino, I.; Reyes, F.; Vicente, F.; Lage, O.M. From Ocean to Medicine: Pharmaceutical Applications of Metabolites from Marine Bacteria. Antibiotics 2020, 9, 455. https://doi.org/10.3390/antibiotics9080455

AMA Style

Santos JD, Vitorino I, Reyes F, Vicente F, Lage OM. From Ocean to Medicine: Pharmaceutical Applications of Metabolites from Marine Bacteria. Antibiotics. 2020; 9(8):455. https://doi.org/10.3390/antibiotics9080455

Chicago/Turabian Style

Santos, José D., Inês Vitorino, Fernando Reyes, Francisca Vicente, and Olga M. Lage 2020. "From Ocean to Medicine: Pharmaceutical Applications of Metabolites from Marine Bacteria" Antibiotics 9, no. 8: 455. https://doi.org/10.3390/antibiotics9080455

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