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Antibiotics, Volume 9, Issue 8

August 2020 - 94 articles

Cover Story: The Earth’s immense oceans are home to a great diversity of biological resources, including copious microorganisms like bacteria that are, still, very much underexplored. In this work, we discuss how some of the greatest health challenges faced by humans, such as the rise of antibiotic resistance in bacteria, pathogenic fungi and parasites, cancer incidence, and viral infection outbreaks, can be tackled by studying the bacteria found in oceans. Moreover, we give an overview of the research pipeline of novel molecules, from the identification of bioactive bacterial crude extracts to the isolation and chemical characterization of the molecules within the framework of the One Health approach. This work demonstrates the current relevance of marine bacteria for the discovery of novel bioactive natural products. View this paper.
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Articles (94)

  • Article
  • Open Access
11 Citations
7,652 Views
12 Pages

The misuse of antibiotics is a worldwide public health concern. Behavioral Intervention programs that aim to reduce patients’ own request for antibiotics during their visit to primary care clinics is an attractive strategy to combat this proble...

  • Article
  • Open Access
11 Citations
7,034 Views
29 Pages

Development of an NGS-Based Workflow for Improved Monitoring of Circulating Plasmids in Support of Risk Assessment of Antimicrobial Resistance Gene Dissemination

  • Bas Berbers,
  • Pieter-Jan Ceyssens,
  • Pierre Bogaerts,
  • Kevin Vanneste,
  • Nancy H. C. Roosens,
  • Kathleen Marchal and
  • Sigrid C. J. De Keersmaecker

Antimicrobial resistance (AMR) is one of the most prominent public health threats. AMR genes localized on plasmids can be easily transferred between bacterial isolates by horizontal gene transfer, thereby contributing to the spread of AMR. Next-gener...

  • Review
  • Open Access
19 Citations
11,247 Views
29 Pages

Aminoglycosides are a class of naturally occurring and semi synthetic antibiotics that have been used for a long time in fighting bacterial infections. Due to acquired antibiotic resistance and inherent toxicity, aminoglycosides have experienced a de...

  • Communication
  • Open Access
7 Citations
4,797 Views
7 Pages

Characterizing Antimicrobial Resistance in Chicken Pathogens: A Step towards Improved Antimicrobial Stewardship in Poultry Production in Vietnam

  • Nguyen Thi Phuong Yen,
  • Nguyen Thi Nhung,
  • Nguyen Thi Bich Van,
  • Nguyen Van Cuong,
  • Bach Tuan Kiet,
  • Doan Hoang Phu,
  • Vo Be Hien,
  • James Campbell,
  • Niwat Chansiripornchai and
  • Guy E. Thwaites
  • + 1 author

In the Mekong Delta of Vietnam, farmers use large quantities of antimicrobials to raise small-scale chicken flocks, often including active ingredients regarded of “critical importance’” by the World Health Organization. Due to limit...

  • Article
  • Open Access
8 Citations
4,701 Views
13 Pages

Helicobacter pylori eradication rate with conventional standard therapy is decreasing owing to antibiotic resistance, necessitating novel antibacterial strategies against H. pylori. We evaluated the efficacy of a gentamicin-intercalated smectite hybr...

  • Article
  • Open Access
10 Citations
4,776 Views
13 Pages

The aim of this study was to investigate the annual incidence of Escherichia coli isolates in urinary tract infections (UTIs) and the antimicrobial resistance of the third-generation cephalosporin (3GCs) to E. coli, including the factors associated w...

  • Review
  • Open Access
57 Citations
11,311 Views
73 Pages

Fosfomycin as Partner Drug for Systemic Infection Management. A Systematic Review of Its Synergistic Properties from In Vitro and In Vivo Studies

  • Roberta Maria Antonello,
  • Luigi Principe,
  • Alberto Enrico Maraolo,
  • Valentina Viaggi,
  • Riccardo Pol,
  • Massimiliano Fabbiani,
  • Francesca Montagnani,
  • Antonio Lovecchio,
  • Roberto Luzzati and
  • Stefano Di Bella

Fosfomycin is being increasingly prescribed for multidrug-resistant bacterial infections. In patients with systemic involvement, intravenous fosfomycin is usually administered as a partner drug, as part of an antibiotic regimen. Hence, the knowledge...

  • Article
  • Open Access
27 Citations
4,942 Views
13 Pages

Evaluation of Antibacterial and Cytotoxic Properties of a Fluorinated Diamond-Like Carbon Coating for the Development of Antibacterial Medical Implants

  • Katsutaka Yonezawa,
  • Masahito Kawaguchi,
  • Ayumi Kaneuji,
  • Toru Ichiseki,
  • Yoshitsugu Iinuma,
  • Kae Kawamura,
  • Kazuhiro Shintani,
  • Shinobu Oda,
  • Makoto Taki and
  • Norio Kawahara

Peri-implant infection is a serious complication in surgical procedures involving implants. We conducted an in vitro study to determine whether the use of a fluorinated diamond-like carbon (F-DLC) coating on a titanium alloy surface can prevent peri-...

  • Article
  • Open Access
19 Citations
7,625 Views
13 Pages

Synergy of Linezolid with Several Antimicrobial Agents against Linezolid-Methicillin-Resistant Staphylococcal Strains

  • María-José Valderrama,
  • María Alfaro,
  • Icíar Rodríguez-Avial,
  • Elvira Baos,
  • Carmen Rodríguez-Avial and
  • Esther Culebras

Linezolid is a synthetic oxazolydinone active against multi-resistant Gram-positive cocci that inhibits proteins synthesis by interacting with the 50S ribosomal subunit. Although linezolid-resistant strains are infrequent, several outbreaks have been...

  • Review
  • Open Access
101 Citations
10,770 Views
12 Pages

Antibiotic Use in Low and Middle-Income Countries and the Challenges of Antimicrobial Resistance in Surgery

  • Massimo Sartelli,
  • Timothy C. Hardcastle,
  • Fausto Catena,
  • Alain Chichom-Mefire,
  • Federico Coccolini,
  • Sameer Dhingra,
  • Mainul Haque,
  • Adrien Hodonou,
  • Katia Iskandar and
  • Francesco M. Labricciosa
  • + 3 authors

Antimicrobial resistance (AMR) is a phenomenon resulting from the natural evolution of microbes. Nonetheless, human activities accelerate the pace at which microorganisms develop and spread resistance. AMR is a complex and multidimensional problem, t...

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Antibiotics - ISSN 2079-6382