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Antibiotics, Volume 9, Issue 8

August 2020 - 94 articles

Cover Story: The Earth’s immense oceans are home to a great diversity of biological resources, including copious microorganisms like bacteria that are, still, very much underexplored. In this work, we discuss how some of the greatest health challenges faced by humans, such as the rise of antibiotic resistance in bacteria, pathogenic fungi and parasites, cancer incidence, and viral infection outbreaks, can be tackled by studying the bacteria found in oceans. Moreover, we give an overview of the research pipeline of novel molecules, from the identification of bioactive bacterial crude extracts to the isolation and chemical characterization of the molecules within the framework of the One Health approach. This work demonstrates the current relevance of marine bacteria for the discovery of novel bioactive natural products. View this paper.
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Articles (94)

  • Article
  • Open Access
21 Citations
4,389 Views
12 Pages

Chemical Profiling and Discrimination of Essential Oils from Six Ferula Species Using GC Analyses Coupled with Chemometrics and Evaluation of Their Antioxidant and Enzyme Inhibitory Potential

  • Fadia S. Youssef,
  • Munira A. Mamatkhanova,
  • Nilufar Z. Mamadalieva,
  • Gokhan Zengin,
  • Salima F. Aripova,
  • Elham Alshammari and
  • Mohamed L. Ashour

The differences in the composition of essential oils obtained from the aerial parts of six Ferula species viz., F. caratavica (Fc), F. kuchistanica (Fk), F. pseudoreoselinum (Fp), F. samarcandica (Fs), F. tenuisecta (Ft) and F. varia (Fv) were detect...

  • Article
  • Open Access
24 Citations
12,853 Views
36 Pages

Background: Bacterial persistence to antibiotics relates to the phenotypic ability to survive lethal concentrations of otherwise bactericidal antibiotics. The quantitative nature of the time–kill assay, which is the sector’s standard for...

  • Review
  • Open Access
48 Citations
7,771 Views
30 Pages

The Ascidian-Derived Metabolites with Antimicrobial Properties

  • Marcello Casertano,
  • Marialuisa Menna and
  • Concetta Imperatore

Among the sub-phylum of Tunicate, ascidians represent the most abundant class of marine invertebrates, with 3000 species by heterogeneous habitat, that is, from shallow water to deep sea, already reported. The chemistry of these sessile filter-feedin...

  • Article
  • Open Access
16 Citations
5,614 Views
9 Pages

Fosfomycin represents a relatively old antibiotic, but it is experiencing a comeback in recent years. According to some studies, the increasing therapeutic use of this drug led to a rapid increase in the levels of resistance in bacteria causing urina...

  • Article
  • Open Access
12 Citations
7,114 Views
18 Pages

The Bristol Sponge Microbiome Collection: A Unique Repository of Deep-Sea Microorganisms and Associated Natural Products

  • Sam E. Williams,
  • Henry L. Stennett,
  • Catherine R. Back,
  • Kavita Tiwari,
  • Jorge Ojeda Gomez,
  • Martin R. Challand,
  • Katharine R. Hendry,
  • James Spencer,
  • Angela E. Essex-Lopresti and
  • Christine L. Willis
  • + 2 authors

The deep ocean is the largest habitat for life on Earth, though the microorganisms that occupy this unique environmental niche remain largely unexplored. Due to the significant logistical and operational challenges associated with accessing the deep...

  • Article
  • Open Access
12 Citations
5,429 Views
36 Pages

Content and Mechanism of Action of National Antimicrobial Stewardship Interventions on Management of Respiratory Tract Infections in Primary and Community Care

  • Lou Atkins,
  • Tim Chadborn,
  • Paulina Bondaronek,
  • Diane Ashiru-Oredope,
  • Elizabeth Beech,
  • Natalie Herd,
  • Victoria de La Morinière,
  • Marta González-Iraizoz,
  • Susan Hopkins and
  • Cliodna McNulty
  • + 1 author

A major modifiable factor contributing to antimicrobial resistance (AMR) is inappropriate use and overuse of antimicrobials, such as antibiotics. This study aimed to describe the content and mechanism of action of antimicrobial stewardship (AMS) inte...

  • Article
  • Open Access
61 Citations
7,128 Views
13 Pages

Background: Carbapenem resistant Klebsiella pneumoniae (CRKP), Pseudomonas aeruginosa (CRPA), and Acinetobacter baumannii (CRAB) pose significant threats to public health. However, the clinical and economic impacts of CRKP, CRPA, and CRAB remain larg...

  • Article
  • Open Access
50 Citations
6,106 Views
16 Pages

Evaluation of Antioxidant, Antimicrobial and Tyrosinase Inhibitory Activities of Extracts from Tricholosporum goniospermum, an Edible Wild Mushroom

  • Paola Angelini,
  • Roberto Venanzoni,
  • Giancarlo Angeles Flores,
  • Bruno Tirillini,
  • Giustino Orlando,
  • Lucia Recinella,
  • Annalisa Chiavaroli,
  • Luigi Brunetti,
  • Sheila Leone and
  • Simonetta Cristina Di Simone
  • + 5 authors

Tricholosporum goniospermum (Bres.) Guzmán ex T.J. Baroni is an excellent edible mushroom whose compounds and biological properties are still unknown. In this study, n-hexane, ethyl acetate and methanol extracts from fruiting bodies and liquid...

  • Review
  • Open Access
16 Citations
6,194 Views
15 Pages

E-Health Tools to Improve Antibiotic Use and Resistances: A Systematic Review

  • Érico Carvalho,
  • Marta Estrela,
  • Maruxa Zapata-Cachafeiro,
  • Adolfo Figueiras,
  • Fátima Roque and
  • Maria Teresa Herdeiro

(1) Background: e-Health tools, especially in the form of clinical decision support systems (CDSSs), have been emerging more quickly than ever before. The main objective of this systematic review is to assess the influence of these tools on antibioti...

  • Article
  • Open Access
15 Citations
6,145 Views
13 Pages

Copper Kills Escherichia coli Persister Cells

  • Paula Maria Moreira Martins,
  • Ting Gong,
  • Alessandra A. de Souza and
  • Thomas K. Wood

Due to their reduced metabolism, persister cells can survive most antimicrobial treatments, which usually rely on corrupting active biochemical pathways. Therefore, molecules that kill bacterial persisters should function in a metabolism-independent...

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Antibiotics - ISSN 2079-6382