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Biosensors, Volume 13, Issue 9

September 2023 - 65 articles

Cover Story: In this study, a modular, multi-purpose, and cost-effective electrochemical biosensor based on a five-stranded four-way junction (5S-4WJ) system was developed for SARS-CoV-2 (genes S and N) and influenza A virus (gene M) detection. The 5S-4WJ structure consists of an electrode-immobilized universal stem-loop (USL) strand, two auxiliary DNA strands, and a universal methylene blue redox strand (UMeB). The sequence-specific auxiliary DNA strands (m and f) ensure selectivity of the biosensor for target recognition utilizing the same USL and UMeB components. The biosensor exhibited minimal loss in the signal after rehybridization, demonstrating its potential as a viable multiplex assay for both current and future pathogens, with a low limit of quantification (LOQ) of as low as 17 pM. View this paper
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Articles (65)

  • Review
  • Open Access
25 Citations
5,214 Views
24 Pages

Recent Progresses in Optical Biosensors for Interleukin 6 Detection

  • Marjan Majdinasab,
  • Marc Lamy de la Chapelle and
  • Jean Louis Marty

21 September 2023

Interleukin 6 (IL-6) is pleiotropic cytokine with pathological pro-inflammatory effects in various acute, chronic and infectious diseases. It is involved in a variety of biological processes including immune regulation, hematopoiesis, tissue repair,...

  • Article
  • Open Access
4 Citations
2,979 Views
27 Pages

Novel Cytochrome P450-3A4 Enzymatic Nanobiosensor for Lapatinib (a Breast Cancer Drug) Developed on a Poly(anilino-co-4-aminobenzoic Acid-Green-Synthesised Indium Nanoparticle) Platform

  • Jaymi Leigh January,
  • Ziyanda Zamaswazi Tshobeni,
  • Nokwanda Precious Pearl Ngema,
  • Abongile Nwabisa Jijana,
  • Emmanuel Iheanyichukwu Iwuoha,
  • Takalani Mulaudzi,
  • Samantha Fiona Douman and
  • Rachel Fanelwa Ajayi

21 September 2023

Breast cancer (BC) is one of the most common types of cancer disease worldwide and it accounts for thousands of deaths annually. Lapatinib is among the preferred drugs for the treatment of breast cancer. Possible drug toxicity effects of lapatinib ca...

  • Review
  • Open Access
29 Citations
5,970 Views
35 Pages

20 September 2023

Given the advancements in modern living standards and technological development, conventional smart devices have proven inadequate in meeting the demands for a high-quality lifestyle. Therefore, a revolution is necessary to overcome this impasse and...

  • Article
  • Open Access
2 Citations
1,988 Views
14 Pages

20 September 2023

The NQ21 peptide has relatively recently attracted attention in the biomedical sphere due to its prospects for facilitating the engineering of the HIV1 vaccine and ELISA test. Today, there is still a need for a reliable and fast methodology that reve...

  • Article
  • Open Access
2 Citations
2,360 Views
18 Pages

Development of a Multiplex HIV/TB Diagnostic Assay Based on the Microarray Technology

  • Kanyane Malatji,
  • Advaita Singh,
  • Christina Thobakgale and
  • Kabamba Alexandre

20 September 2023

Currently there are diagnostic tests available for human immunodeficiency virus (HIV) and tuberculosis (TB); however, they are still diagnosed separately, which can delay treatment in cases of co-infection. Here we report on a multiplex microarray te...

  • Review
  • Open Access
24 Citations
7,714 Views
27 Pages

19 September 2023

Neurotransmitters are chemical compounds released by nerve cells, including neurons, astrocytes, and oligodendrocytes, that play an essential role in the transmission of signals in living organisms, particularly in the central nervous system, and the...

  • Article
  • Open Access
6 Citations
2,707 Views
15 Pages

Tablet-Based Sensor: A Stable and User-Friendly Tool for Point-of-Care Detection of Glucose in Urine

  • Hasti Hajimiri,
  • Seyed Hamid Safiabadi Tali,
  • Muna Al-Kassawneh,
  • Zubi Sadiq and
  • Sana Jahanshahi-Anbuhi

19 September 2023

The colorimetric detection of glucose in urine through enzymatic reactions offers a low-cost and non-invasive method to aid in diabetes management. Nonetheless, the vulnerability of enzymes to environmental conditions, particularly elevated temperatu...

  • Review
  • Open Access
16 Citations
4,198 Views
32 Pages

19 September 2023

Over the past ten years, microfluidic paper-based analytical devices (micro-PADs) have attracted a lot of attention as a viable analytical platform. It is expanding as a result of advances in manufacturing processes and device integration. Convention...

  • Article
  • Open Access
1 Citations
2,593 Views
17 Pages

Genetically Encoded Fluorescent Probe for Detection of Heme-Induced Conformational Changes in Cytochrome c

  • Mehmet Yunus Genceroglu,
  • Cansu Cavdar,
  • Selen Manioglu and
  • Halil Bayraktar

18 September 2023

Cytochrome c (Cytc) is a key redox protein for energy metabolism and apoptosis in cells. The activation of Cytc is composed of several steps, including its transfer to the mitochondrial membrane, binding to cytochrome c heme lyase (CCHL) and covalent...

  • Article
  • Open Access
2 Citations
2,406 Views
12 Pages

18 September 2023

Uniform and stable droplet generation is critical for accurate and efficient digital nucleic acid analysis (dNAA). In this study, an integrated microfluidic step emulsification device with wide-range droplet generation capability, small device dimens...

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Biosensors - ISSN 2079-6374Creative Common CC BY license