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Biosensors
Special Issues
Nanophotonic Approaches to Biosensing and Bioimaging Applications
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Nanophotonic Approaches to Biosensing and Bioimaging Applications

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Optical and Photonic Biosensors".

Deadline for manuscript submissions: closed (29 February 2024) | Viewed by 5562

Special Issue Editors

Prof. Dr. Biqin Dong

E-Mail Website
Guest Editor
Academy for Engineering and Technology, Fudan University, Shanghai, China
Interests: nanophotonics; optical sensors; biomedical optical imaging
Dr. Hao Li

E-Mail Website
Guest Editor
National Innovation Center for Advanced Medical Devices, Shenzhen, China
Interests: micro/nano-photonics; microfluidics; biosensing; bioimaging

Special Issue Information

Dear Colleagues,

Nanophotonics offers unprecedented potential in designing and engineering novel optical devices for biosensing and bioimaging with its extraordinary capability of controlling electromagnetic waves with sub-wavelength scale photonic structures. It enables enhanced capabilities and new functionalities for sensing chemical and physical variations with extraordinary sensing performance beyond the current limit, distinguishing multiple elements with the signal previously hidden, achieving the measurements with exceptional scale and speed, as well as offering novel bioimaging mechanisms with enriched contrasts and improved resolution. Advanced micro/nano manufacturing technologies further offer more options for materials, extended functionality, and reduced per-unit costs to achieve customized nanophotonic devices for abundant convenient applications in numerous vital areas, including healthcare, pharmaceutics, food safety, environmental monitoring, security, etc. We welcome all types of submissions, including original research papers, reviews, perspectives, methods, or technical reports, that will help enrich the field for the existing community as well as for newcomers.

Prof. Dr. Biqin Dong
Dr. Hao Li
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanophotonics
  • biosensing
  • bioimaging
  • optical biomaterial
  • optical nanomaterial
  • micro-/nanofabrication

Published Papers (3 papers)

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Research

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11 pages, 4104 KiB  
Article
Sensitivity Equalization and Dynamic Range Expansion with Multiple Optofluidic Microbubble Resonator Sensors
by Ye Wang, Xuyang Zhao, Liying Liu, Xiang Wu and Lei Xu
Biosensors 2023, 13(10), 911; https://doi.org/10.3390/bios13100911 - 28 Sep 2023
Viewed by 974
Abstract
A novel multi-optofluidic microbubble resonator (OMBR) sensitivity equalization method is presented that equalizes the sensing signal from different OMBRs. The method relies on the fact that the ratio of the wavelength shifts to the bulk refractive index sensitivity (BRIS) does not depend on [...] Read more.
A novel multi-optofluidic microbubble resonator (OMBR) sensitivity equalization method is presented that equalizes the sensing signal from different OMBRs. The method relies on the fact that the ratio of the wavelength shifts to the bulk refractive index sensitivity (BRIS) does not depend on the physical dimensions of the OMBR. The proof of concept is experimentally validated and the sensing signals from individual OMBRs can be directly compared. Furthermore, a wide dynamic range of sensing with favorable consistency and repeatability is achieved by piecing together signals from 20 OMBRs for HIV-1 p24 antigen detection from 50 fg/mL to 100 ng/mL (2.1 fM to 4.2 nM), indicating significant potential for practical applications, such as in drug screening and disease diagnosis. Full article
(This article belongs to the Special Issue Nanophotonic Approaches to Biosensing and Bioimaging Applications)
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9 pages, 5665 KiB  
Communication
Microlens-Assisted Light-Scattering Imaging of Plasmonic Nanoparticles at the Single Particle Level
by Pengcheng Zhang, Tingting Zhan, Sha Xue and Hui Yang
Biosensors 2023, 13(9), 871; https://doi.org/10.3390/bios13090871 - 6 Sep 2023
Viewed by 1014
Abstract
We present a microlens-assisted imaging approach to record the scattering light of plasmonic nanoparticles at the single particle level. The microlens can significantly enhance the backscattering of visible light from individual plasmonic nanoparticles by several dozen folds, and single gold nanoparticles with a [...] Read more.
We present a microlens-assisted imaging approach to record the scattering light of plasmonic nanoparticles at the single particle level. The microlens can significantly enhance the backscattering of visible light from individual plasmonic nanoparticles by several dozen folds, and single gold nanoparticles with a diameter as low as 60 nm can be imaged under a conventional optical microscope. This can benefit from a significant increase in the scattering intensity afforded by the microlens, meaning that the imaging of gold nanoparticles at a high temporal resolution (up to 5000 Hz) can be achieved, which is fast enough to record single particle adhesion events on the substrate. This research presents a fast and efficient means of acquiring scattering light from plasmonic nanoparticles, which has great potential to develop plasmonic nanoparticle-based biosensors and investigate a wide range of plasmonic nanoparticle-based fast interaction processes. Full article
(This article belongs to the Special Issue Nanophotonic Approaches to Biosensing and Bioimaging Applications)
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Review

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18 pages, 3767 KiB  
Review
Label-Free Bound-States-in-the-Continuum Biosensors
by Man Luo, Yi Zhou, Xuyang Zhao, Yuxiang Li, Zhihe Guo, Xi Yang, Meng Zhang, You Wang and Xiang Wu
Biosensors 2022, 12(12), 1120; https://doi.org/10.3390/bios12121120 - 2 Dec 2022
Cited by 8 | Viewed by 2704
Abstract
Bound states in the continuum (BICs) have attracted considerable attentions for biological and chemical sensing due to their infinite quality (Q)-factors in theory. Such high-Q devices with enhanced light-matter interaction ability are very sensitive to the local refractive index changes, [...] Read more.
Bound states in the continuum (BICs) have attracted considerable attentions for biological and chemical sensing due to their infinite quality (Q)-factors in theory. Such high-Q devices with enhanced light-matter interaction ability are very sensitive to the local refractive index changes, opening a new horizon for advanced biosensing. In this review, we focus on the latest developments of label-free optical biosensors governed by BICs. These BICs biosensors are summarized from the perspective of constituent materials (i.e., dielectric, metal, and hybrid) and structures (i.e., grating, metasurfaces, and photonic crystals). Finally, the current challenges are discussed and an outlook is also presented for BICs inspired biosensors. Full article
(This article belongs to the Special Issue Nanophotonic Approaches to Biosensing and Bioimaging Applications)
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