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Biosensors, Volume 12, Issue 8

August 2022 - 117 articles

Cover Story: We report the first electrochemical immunoplatform for the quantification of the CCL5 biomarker at the clinically required levels; it is able to discriminate between patients diagnosed with MS and healthy individuals. The immunosensing device involves protein capture from biological samples by complexation with biotinylated specific antibodies immobilized onto neutravidin-functionalized microparticles and sandwich assay with anti-CCL5 antibody and IgG labelled with horseradish peroxidase (HRP) for the enzyme-catalyzed amperometric detection of H2O2 using hydroquinone (HQ) as the redox mediator. The method shows excellent analytical performance for clinical application with a wide linear range of concentrations (0.1–300 ng·mL−1 CCL5, R2 = 0.998) and a low detection limit (40 pg·mL−1 CCL5). View this paper
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Articles (117)

  • Review
  • Open Access
11 Citations
3,401 Views
16 Pages

AIEgen-Peptide Bioprobes for the Imaging of Organelles

  • Bochao Chen,
  • Haotong Yuan,
  • Wei Zhang,
  • Jingjing Hu,
  • Xiaoding Lou and
  • Fan Xia

22 August 2022

Organelles are important subsystems of cells. The damage and inactivation of organelles are closely related to the occurrence of diseases. Organelles’ functional activity can be observed by fluorescence molecular tools. Nowadays, a series of ag...

  • Communication
  • Open Access
4 Citations
2,828 Views
8 Pages

22 August 2022

A desirable lanthanide-based ratiometric fluorescence probe was designed as a multifunctional nanoplatform for the determination of dipicolinic acid (DPA), a unique bacterial endospore biomarker, with high selectivity and sensitivity. The carbon dots...

  • Review
  • Open Access
27 Citations
8,629 Views
21 Pages

Portable Electrochemical Biosensors Based on Microcontrollers for Detection of Viruses: A Review

  • Muhammad Afiq Abdul Ghani,
  • Anis Nurashikin Nordin,
  • Munirah Zulhairee,
  • Adibah Che Mohamad Nor,
  • Mohd Shihabuddin Ahmad Noorden,
  • Muhammad Khairul Faisal Muhamad Atan,
  • Rosminazuin Ab Rahim and
  • Zainiharyati Mohd Zain

22 August 2022

With the rise of zoonotic diseases in recent years, there is an urgent need for improved and more accessible screening and diagnostic methods to mitigate future outbreaks. The recent COVID-19 pandemic revealed an over-reliance on RT-PCR, a slow, cost...

  • Article
  • Open Access
7 Citations
3,963 Views
14 Pages

A High Accuracy & Ultra-Low Power ECG-Derived Respiration Estimation Processor for Wearable Respiration Monitoring Sensor

  • Jiajing Fan,
  • Siqi Yang,
  • Jiahao Liu,
  • Zhen Zhu,
  • Jianbiao Xiao,
  • Liang Chang,
  • Shuisheng Lin and
  • Jun Zhou

22 August 2022

The respiratory rate is widely used for evaluating a person’s health condition. Compared to other invasive and expensive methods, the ECG-derived respiration estimation is a more comfortable and affordable method to obtain the respiration rate....

  • Article
  • Open Access
20 Citations
5,662 Views
13 Pages

21 August 2022

A cost-effective, simple, flexible, and disposable colorimetric film sensor was constructed for the rapid detection of gaseous ammonia. The sensor was designed to consist of three layers, namely top, middle, and bottom layers of a polymeric elastomer...

  • Article
  • Open Access
10 Citations
3,356 Views
12 Pages

In-Depth Characterization of Endo-Lysosomal Aβ in Intact Neurons

  • Alec K. McKendell,
  • Mei C. Q. Houser,
  • Shane P. C. Mitchell,
  • Michael S. Wolfe,
  • Oksana Berezovska and
  • Masato Maesako

20 August 2022

Amyloid-beta (Aβ) peptides are produced within neurons. Some peptides are released into the brain parenchyma, while others are retained inside the neurons. However, the detection of intracellular Aβ remains a challenge since antibodies agai...

  • Article
  • Open Access
9 Citations
3,352 Views
15 Pages

Multi-Factors Cooperatively Actuated Photonic Hydrogel Aptasensors for Facile, Label-Free and Colorimetric Detection of Lysozyme

  • Peiyan Shen,
  • Yuqing Shi,
  • Ran Li,
  • Bo Han,
  • Haojie Ma,
  • Xueyan Hou,
  • Yuqi Zhang and
  • Lei Jiang

20 August 2022

Responsive two-dimensional photonic crystal (2DPC) hydrogels have been widely used as smart sensing materials for constructing various optical sensors to accurately detect different target analytes. Herein, we report photonic hydrogel aptasensors bas...

  • Article
  • Open Access
25 Citations
4,502 Views
12 Pages

20 August 2022

Loop-mediated isothermal amplification (LAMP) is a nucleic acid amplification method that allows the simple, quick, and low-cost detection of various viral genes. LAMP assays are susceptible to generating non-specific amplicons, as high concentration...

  • Article
  • Open Access
8 Citations
3,310 Views
23 Pages

19 August 2022

We have previously shown that human melanoma cells rapidly decrease human brain endothelial barrier strength. Our findings showed a fast mechanism of melanoma mediated barrier disruption, which was localised to the paracellular junctions of the brain...

  • Article
  • Open Access
12 Citations
4,386 Views
16 Pages

19 August 2022

Cell encapsulation has been widely employed in cell therapy, characterization, and analysis, as well as many other biomedical applications. While droplet-based microfluidic technology is advantageous in cell microencapsulation because of its modulari...

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Biosensors - ISSN 2079-6374