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Journal of Clinical Medicine, Volume 9, Issue 11

November 2020 - 409 articles

Cover Story: Perturbations in mitochondrial dysfunction play significant role in the pathogenesis of HF. Pathophysiological mechanisms leading to mitochondrial dysfunction in HF are numerous and range from changes in morphology and dynamics; to altered endoplasmic reticulum (ER)-mitochondrial (mt) tethering due to altered signaling and calcium cycling at the ER-mt interphase; enhanced mt-calcium uptake and overload; increased reactive oxygen species and apoptosis; and decreased mt-biogenesis, and oxidative capacity. Investigational drugs targeting specific areas of mt-dysfunction are being investigated. There remain an unmet need to explore molecular mechanisms modulating the multiplicity of mt-dysfunction in HF for better effective therapeutic interventions. View this paper
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Articles (409)

  • Article
  • Open Access
18 Citations
3,336 Views
13 Pages

22 November 2020

Frailty is a geriatric syndrome represented by susceptibility to precipitating health events and reduced functional reserve. Frailty can be difficult to measure in clinical practice and research. One approach to approximate frailty is based on a defi...

  • Article
  • Open Access
15 Citations
6,972 Views
11 Pages

22 November 2020

This study investigated the incidence of failure after locking compression plate (LCP) osteosynthesis around a well-fixed stem of periprosthetic femoral fractures (PFFs). We retrospectively evaluated outcomes of 63 Vancouver type B1 and C PFFs treate...

  • Article
  • Open Access
8 Citations
2,298 Views
14 Pages

Characteristic of Oral Squamous Cell Carcinoma Tissues Using Isotope Ratio Mass Spectrometry

  • Katarzyna Bogusiak,
  • Aleksandra Puch,
  • Radosław Mostowski,
  • Marcin Kozakiewicz,
  • Piotr Paneth and
  • Józef Kobos

22 November 2020

Overall prognosis for patients with oral squamous cell carcinomas (OSSC) is still unfavourable. However, there is a hope that a novel diagnostic method may establish better cancer biology characteristics. The aim of this study was to evaluate the iso...

  • Feature Paper
  • Article
  • Open Access
12 Citations
2,970 Views
12 Pages

Physiological Criteria Are Useful for the Diagnosis of Idiopathic Pleuroparenchymal Fibroelastosis

  • Takato Ikeda,
  • Yoshiaki Kinoshita,
  • Yusuke Ueda,
  • Tomoya Sasaki,
  • Hisako Kushima and
  • Hiroshi Ishii

22 November 2020

Background: Diagnostic criteria of idiopathic pleuroparenchymal fibroelastosis (IPPFE) were recently proposed, including physiological criteria of the body mass index (BMI) and percentage of the predicted values of residual volume (RV)/total lung cap...

  • Review
  • Open Access
39 Citations
5,239 Views
9 Pages

Effects of Obesity and Asthma on Lung Function and Airway Dysanapsis in Adults and Children

  • Ebymar Arismendi,
  • Marina Bantulà,
  • Miguel Perpiñá and
  • César Picado

22 November 2020

Obesity increases the risk of developing asthma in children and adults. Obesity is associated with different effects on lung function in children and adults. In adults, obesity has been associated with reduced lung function resulting from a relativel...

  • Article
  • Open Access
6 Citations
3,017 Views
13 Pages

Prediction of Infarct Growth and Neurological Deterioration in Patients with Vertebrobasilar Artery Occlusions

  • Seungyon Koh,
  • Ji Hyun Park,
  • Bumhee Park,
  • Mun Hee Choi,
  • Sung Eun Lee,
  • Jin Soo Lee,
  • Ji Man Hong and
  • Seong-Joon Lee

22 November 2020

We aimed to identify predictors of infarct growth and neurological deterioration (ND) in vertebrobasilar occlusions (VBOs) with a focus on clinical-core mismatch. From 2010 to 2018, VBO patients were selected from a university hospital registry. In t...

  • Article
  • Open Access
16 Citations
3,703 Views
19 Pages

Assessing the Effectiveness of Pirfenidone in Idiopathic Pulmonary Fibrosis: Long-Term, Real-World Data from European IPF Registry (eurIPFreg)

  • Ekaterina Krauss,
  • Silke Tello,
  • Jochen Wilhelm,
  • Johanna Schmidt,
  • Mark Stoehr,
  • Werner Seeger,
  • Ruth C. Dartsch,
  • Bruno Crestani and
  • Andreas Guenther

22 November 2020

Background: Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrotic pulmonary disease with rising incidence. In this study the effectiveness of pirfenidone, as measured by longitudinal change in individual slope of forced vital capacity...

  • Article
  • Open Access
12 Citations
2,932 Views
12 Pages

Collagenated Synthetic Bone Substitute Material for Sinus Floor Elevation at Sites with a Perforated Schneiderian Membrane

  • Sangyup Kim,
  • Jong-Hyuk Chung,
  • Seung-Yun Shin,
  • Seung-Il Shin,
  • Ji-Youn Hong and
  • Hyun-Chang Lim

22 November 2020

Schneiderian membrane perforation (SMP) is the most common complication during sinus floor elevation (SFE). Conventional methods to repair SMP, such as using a collagen barrier, may be clinically demanding. The aim of the present study was to compare...

  • Feature Paper
  • Article
  • Open Access
13 Citations
2,933 Views
25 Pages

Functional Assessment of Outer and Middle Macular Layers in Multiple Sclerosis

  • Lucia Ziccardi,
  • Lucilla Barbano,
  • Laura Boffa,
  • Maria Albanese,
  • Carolina Gabri Nicoletti,
  • Doriana Landi,
  • Andrzej Grzybowski,
  • Benedetto Falsini,
  • Girolama Alessandra Marfia and
  • Diego Centonze
  • + 1 author

22 November 2020

The involvement of macular preganglionic elements’ function, during the neurodegenerative process of multiple sclerosis (MS), is controversial. In this case-control observational and retrospective study, we assessed multifocal electroretinogram...

  • Article
  • Open Access
17 Citations
5,609 Views
9 Pages

22 November 2020

Purpose: To investigate the response to gabapentin treatment in patients with dry eye (DE) accompanied by features of neuropathic ocular pain (NOP), and to analyze the differences between clinical manifestations of the groups according to treatment r...

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J. Clin. Med. - ISSN 2077-0383