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Journal of Clinical Medicine, Volume 7, Issue 7

2018 July - 24 articles

Cover Story: Despite significant investments into antibiotic discovery in the past, no new antibiotic class with novel mode(s) of action against Pseudomonas aeruginosa has been approved in half a century. The reasons for this failure have been identified and are caused by low outer membrane permeability and extensive efflux. To overcome these challenges tobramycin-linked efflux pump inhibitor conjugates (TOB-EPI) have been designed as adjuvants. TOB-EPI conjugates are capable of enhancing antimicrobial potency and/or restoring microbiologicial efficacy in select antibiotics including fluoroquinolones, rifampicin and fosfomycin against a panel of multi drug-resistant P. aeruginosa isolates. TOB-EPI conjugates are believed to interfere with the bacterial membranes thereby enhancing the intracellular concentration of the primary antibiotic. View this paper
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Articles (24)

  • Review
  • Open Access
6 Citations
5,958 Views
10 Pages

Left main coronary artery (LMCA) stenosis has long been recognized as a marker of increased morbidity and mortality. Current treatment algorithms for LMCA stenosis consider both percutaneous coronary intervention (PCI) with drug eluting stents (DES)...

  • Article
  • Open Access
29 Citations
14,986 Views
15 Pages

Investigation on the Use of Traditional Chinese Medicine for Polycystic Ovary Syndrome in a Nationwide Prescription Database in Taiwan

  • Wan-Ting Liao,
  • Jen-Huai Chiang,
  • Chia-Jung Li,
  • Ming-Tsung Lee,
  • Cheng-Chiung Su and
  • Hung-Rong Yen

Polycystic ovary syndrome (PCOS) is a common condition, affecting 5–10% of women of reproductive age worldwide. It has serious reproductive implications and causes mood disorders and metabolic disorders, such as type-2 diabetes. Because PCOS reflects...

  • Article
  • Open Access
22 Citations
4,268 Views
8 Pages

The Nutrition Knowledge of Croatian General Practitioners

  • Albina Dumic,
  • Maja Miskulin,
  • Nika Pavlovic,
  • Zelimir Orkic,
  • Vesna Bilic-Kirin and
  • Ivan Miskulin

Nutrition care delivered in primary health care setting is an effective and necessary preventive health care measure. General practitioners (GPs) nutrition knowledge is related to their nutrition care practice. The aim of this study was to explore th...

  • Article
  • Open Access
16 Citations
6,315 Views
9 Pages

Interference with Processing Negative Stimuli in Problematic Internet Users: Preliminary Evidence from an Emotional Stroop Task

  • Adriano Schimmenti,
  • Vladan Starcevic,
  • Alessia M. Gervasi,
  • Jory Deleuze and
  • Joël Billieux

Although it has been proposed that problematic Internet use (PIU) may represent a dysfunctional coping strategy in response to negative emotional states, there is a lack of experimental studies that directly test how individuals with PIU process emot...

  • Case Report
  • Open Access
4 Citations
5,850 Views
6 Pages

Septic Pulmonary Emboli or Pulmonary Metastasis in a Patient with Diabetes Mellitus?

  • Meng-Yu Wu,
  • Ling-Chi Lee,
  • Yu-Long Chen,
  • Yung-Hsiang Yeh,
  • Chia-Jung Li and
  • Giou-Teng Yiang

Emphysematous pyelonephritis is a rare but life-threatening infection characterized by an accumulation of gas in the renal parenchyma. A high mortality rate was reported, and timely administration of broad-spectrum antibiotics for enteric gram-negati...

  • Article
  • Open Access
8 Citations
4,721 Views
12 Pages

Differential Roles of Tumor Necrosis Factor Ligand Superfamily Members as Biomarkers in Pancreatic Cancer

  • Ines Pombeiro,
  • Sven H. Loosen,
  • Sanchari Roy,
  • Florian Schueller,
  • Lukas Niewenhuisen,
  • Mark Luedde,
  • Mihael Vucur,
  • Frank Tacke,
  • Marcel Binnebösel and
  • Christoph Roderburg
  • + 4 authors

The tumor necrosis factor–related weak inducer of apoptosis (TWEAK) belongs to the tumor necrosis factor ligand superfamily, which was shown to play an important role in inflammatory and malignant gastrointestinal diseases, including colitis or color...

  • Article
  • Open Access
7 Citations
4,095 Views
9 Pages

Pattern of Response to Bronchial Challenge with Histamine in Patients with Non-Atopic Cough-Variant and Classic Asthma

  • Vladimir Zugic,
  • Natasa Mujovic,
  • Sanja Hromis,
  • Jelena Jankovic,
  • Mirjana Drvenica,
  • Aleksandra Perovic,
  • Ivan Kopitovic,
  • Aleksandra Ilic and
  • Dejan Nikolic

Background: The aim of this study was to establish whether non-atopic patients with cough variant asthma (CVA) have different pattern of response to direct bronchoconstrictors than non-atopic patients with classic asthma (CA). Method: A total of 170...

  • Article
  • Open Access
21 Citations
6,381 Views
16 Pages

Infants’ early exposure to painful procedures can have negative short and long-term effects on cognitive, neurological, and brain development. However, infants cannot express their subjective pain experience, as they do not communicate in any languag...

  • Review
  • Open Access
28 Citations
7,451 Views
15 Pages

Endothelial Cell Aging: How miRNAs Contribute?

  • Munekazu Yamakuchi and
  • Teruto Hashiguchi

Endothelial cells (ECs) form monolayers and line the interior surfaces of blood vessels in the entire body. In most mammalian systems, the capacity of endothelial cells to divide is limited and endothelial cells are prone to be senescent. Aging of EC...

  • Article
  • Open Access
8 Citations
3,912 Views
8 Pages

Association between Urinary Calcium Excretion and Estimated Glomerular Filtration Rate Decline in Patients with Type 2 Diabetes Mellitus: A Retrospective Single-center Observational Study

  • Hodaka Yamada,
  • Shunsuke Funazaki,
  • Daisuke Suzuki,
  • Rika Saikawa,
  • Masashi Yoshida,
  • Masafumi Kakei,
  • San-e Ishikawa,
  • Yoshiyuki Morisita and
  • Kazuo Hara

Urinary calcium excretion is not known to predict progression of renal dysfunction in patients with type 2 diabetes mellitus. This study aimed to investigate associations between urinary calcium excretion and progression of estimated glomerular filtr...

  • Article
  • Open Access
64 Citations
6,891 Views
15 Pages

Tumor B7-H3 (CD276) Expression and Survival in Pancreatic Cancer

  • Kentaro Inamura,
  • Yutaka Takazawa,
  • Yosuke Inoue,
  • Yusuke Yokouchi,
  • Maki Kobayashi,
  • Akio Saiura,
  • Tomoko Shibutani and
  • Yuichi Ishikawa

B7-H3 (CD276), a member of the family of immune modulators, orchestrates antitumor immunity. To date, only small-sized studies have examined the association of B7-H3 expression with survival in pancreatic cancer, yielding inconclusive results. We eva...

  • Article
  • Open Access
35 Citations
5,227 Views
9 Pages

A Survey on the Knowledge and Attitudes of Italian Medical Students toward Body Donation: Ethical and Scientific Considerations

  • Rosagemma Ciliberti,
  • Matteo Gulino,
  • Valentina Gazzaniga,
  • Fabio Gallo,
  • Valerio Gaetano Vellone,
  • Francesco De Stefano,
  • Pierluigi Santi and
  • Ilaria Baldelli

Post mortem body donation (PMBD) for medical training and research plays a key role in medical-surgical education. The aim of this study is to evaluate Italian medical students’ awareness and attitudes regarding this practice. A questionnaire was sen...

  • Article
  • Open Access
31 Citations
5,113 Views
12 Pages

Physical Frailty and Amyloid-β Deposits in the Brains of Older Adults with Cognitive Frailty

  • Dong Hyun Yoon,
  • Jun-Young Lee,
  • Seong A Shin,
  • Yu Kyeong Kim and
  • Wook Song

Background: Cognitive frailty and impairment are phenotypically and pathophysiologically correlated with physical frailty. We examined associations between accumulation of amyloid-β in the brain as a brain imaging biomarker and phenotypes of physical...

  • Review
  • Open Access
24 Citations
6,210 Views
11 Pages

Effects of Low Energy Availability on Reproductive Functions and Their Underlying Neuroendocrine Mechanisms

  • Takeshi Iwasa,
  • Toshiya Matsuzaki,
  • Kiyohito Yano,
  • Yiliyasi Mayila,
  • Rie Yanagihara,
  • Yuri Yamamoto,
  • Akira Kuwahara and
  • Minoru Irahara

It is known that metabolic disturbances suppress reproductive functions in females. The mechanisms underlying metabolic and nutritional effects on reproductive functions have been established based on a large body of clinical and experimental data. F...

  • Article
  • Open Access
20 Citations
6,531 Views
9 Pages

Effect of Squat Exercises on Lung Function in Elderly Women with Sarcopenia

  • Yun Kyung Jeon,
  • Myung Jun Shin,
  • Cheol Min Kim,
  • Byeong-Ju Lee,
  • Sang Hun Kim,
  • Da Som Chae,
  • Jong-Hwan Park,
  • Yong Seok So,
  • Hyuntae Park and
  • In Joo Kim
  • + 4 authors

We explored whether a mechanically-assisted squat exercise improved muscle mass, muscle function, and pulmonary function in elderly women with or without sarcopenia. In total, 76 community-dwelling elderly subjects (>60 years of age) were screened...

  • Review
  • Open Access
55 Citations
10,338 Views
12 Pages

The role of the respiratory physician in diagnosing lung cancer has increased in complexity over the last 20 years. Adenocarcinoma is now the prevailing histopathological sub-type of non-small cell lung cancer (NSCLC) resulting in more peripheral can...

  • Case Report
  • Open Access
1 Citations
4,738 Views
5 Pages

An Unusual and Fatal Cause of Miliary Nodules on Chest Radiography

  • Anmol Cheema,
  • Saira Chaughtai,
  • Usman Mazahir,
  • Manimala Roy and
  • Mohammad A. Hossain

Foreign body granulomatosis has many etiologies, including the injection of oral medications intravenously. The insoluble filler materials that are used in the medications can lodge in pulmonary arterioles and capillaries, which can trigger foreign b...

  • Article
  • Open Access
22 Citations
6,539 Views
10 Pages

Background: This study examined the effects of a 4-week technology-enhanced physical activity (PA) interventions on students’ real-time daily PA and aerobic fitness levels. Methods: 116 fifth-graders were assigned to one intervention group (n =...

  • Article
  • Open Access
5 Citations
3,601 Views
10 Pages

Morphogenetic Variability and Hypertension in Ischemic Stroke Patients—Preliminary Study

  • Milan Savic,
  • Suzana Cvjeticanin,
  • Milica Lazovic,
  • Ljubica Nikcevic and
  • Dejan Nikolic

In this study, we evaluated and compared the morphogenetic variability and the degree of recessive homozygosity in patients with manifested ischemic stroke compared to healthy controls. We have evaluated 120 patients with manifested ischemic stroke,...

  • Article
  • Open Access
56 Citations
5,770 Views
9 Pages

We seek to define inflammatory markers, lipid and protein profiles that may aid in distinguishing lung cancer cases from those who are healthy and to determine the relationships between these levels and cancer stage and cell type. Lung cancer patient...

  • Article
  • Open Access
5 Citations
3,984 Views
13 Pages

Healing of Ischemic Colon Anastomosis in Rats Could Be Provided by Administering Dexpanthenol or Coenzyme Q10

  • Faruk Pehlivanlı,
  • Oktay Aydin,
  • Gökhan Karaca,
  • Gülçin Aydin,
  • Tuba Devrim,
  • Huri Bulut,
  • Bülent Bakar and
  • Çağatay Erden Daphan

Background: In this study, the effectiveness of dexpanthenol and coenzyme Q10 (CoQ10) on the healing of ischemic colon anastomosis was investigated. Methods: Forty eight male Wistar Albino rats were divided into four equal groups (Sham-S, Sham-I, DXP...

  • Article
  • Open Access
28 Citations
5,983 Views
12 Pages

In this study, we examined the in vitro effect of tobramycin-efflux pump inhibitor (TOB-EPI) conjugates in combinations with fluoroquinolones, rifampicin and fosfomycin on the growth of multi-drug resistant (MDR) and extremely-drug resistant (XDR) Ps...

  • Article
  • Open Access
5 Citations
4,045 Views
8 Pages

Serum Levels of Angiopoietin-Like Protein 2 and Obestatin in Iranian Women with Polycystic Ovary Syndrome and Normal Body Mass Index

  • Elham Rahmani,
  • Samad Akbarzadeh,
  • Ainaz Broomand,
  • Fatemeh Torabi,
  • Niloofar Motamed and
  • Marzieh Zohrabi

Background: Polycystic ovary syndrome (PCOS) is a common endocrine disease in women of reproduction age and a major cause of anovulatory infertility. Insulin resistance plays an important role in the development and durability of this disorder. ANGPT...

  • Article
  • Open Access
44 Citations
6,250 Views
7 Pages

Previous experimental work suggests that acute exercise may positively influence the accurate recall of past episodic events. However, few studies have examined whether acute exercise also reduces the number of false episodic memories. We evaluated t...

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J. Clin. Med. - ISSN 2077-0383