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J. Clin. Med. 2018, 7(7), 171; https://doi.org/10.3390/jcm7070171

Association between Urinary Calcium Excretion and Estimated Glomerular Filtration Rate Decline in Patients with Type 2 Diabetes Mellitus: A Retrospective Single-center Observational Study

1
Department of Medicine, Division of Endocrinology and Metabolism, Jichi Medical University Saitama Medical Center, 1-847 Amanuma-cho, Omiya-ku, Saitama 330-8503, Japan
2
Division of Endocrinology and Metabolism, International University of Health and Welfare Hospital, 537-3 Iguchi, Nasushiobara, Tochigi 329-2763, Japan
3
Department of Medicine, Division of Nephrology, Jichi Medical University Saitama Medical Center, 1-847 Amanuma-cho, Omiya-ku, Saitama 330-8503, Japan
*
Author to whom correspondence should be addressed.
Received: 18 June 2018 / Revised: 7 July 2018 / Accepted: 8 July 2018 / Published: 10 July 2018
(This article belongs to the Section Endocrinology & Metabolism)
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Abstract

Urinary calcium excretion is not known to predict progression of renal dysfunction in patients with type 2 diabetes mellitus. This study aimed to investigate associations between urinary calcium excretion and progression of estimated glomerular filtration rate (eGFR) in type 2 diabetic patients. This study was a retrospective, single-center, observational cohort study. We enrolled a total of 89 patients with type 2 diabetes mellitus and the average follow-up period was 7.2 ± 1.0 years. We divided patients into two groups based on the median of annual decline in the slope of eGFR, then defined the over-median population as the progressed group and under-median population as the non-progressed group. Median of annual decline in the slope of eGFR was −1.1 mL/min/1.73 m2/year. Correlation coefficient analysis showed positive correlation of urinary calcium excretion with eGFR (r = 0.39, p < 0.001). Multivariate logistic analysis showed that baseline eGFR and urinary calcium excretion were independent variables for progression of eGFR decline. Urinary calcium excretion could be a useful metabolic parameter for predicting decline in slope of eGFR in patients with type 2 diabetes mellitus. View Full-Text
Keywords: Urinary calcium excretion; chronic kidney disease; diabetes; fibroblast growth factor 23; mineral and bone disorder Urinary calcium excretion; chronic kidney disease; diabetes; fibroblast growth factor 23; mineral and bone disorder
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Yamada, H.; Funazaki, S.; Suzuki, D.; Saikawa, R.; Yoshida, M.; Kakei, M.; Ishikawa, S.-E.; Morisita, Y.; Hara, K. Association between Urinary Calcium Excretion and Estimated Glomerular Filtration Rate Decline in Patients with Type 2 Diabetes Mellitus: A Retrospective Single-center Observational Study. J. Clin. Med. 2018, 7, 171.

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