Next Article in Journal
Association between Urinary Calcium Excretion and Estimated Glomerular Filtration Rate Decline in Patients with Type 2 Diabetes Mellitus: A Retrospective Single-center Observational Study
Previous Article in Journal
Physical Frailty and Amyloid-β Deposits in the Brains of Older Adults with Cognitive Frailty
Open AccessReview

Endothelial Cell Aging: How miRNAs Contribute?

Department of Laboratory and Vascular Medicine, Cardiovascular and Respiratory Disorders, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1, Sakuragaoka, Kagoshima 890-8520, Japan
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2018, 7(7), 170; https://doi.org/10.3390/jcm7070170
Received: 15 June 2018 / Revised: 4 July 2018 / Accepted: 9 July 2018 / Published: 10 July 2018
(This article belongs to the Section Molecular Medicine)
Endothelial cells (ECs) form monolayers and line the interior surfaces of blood vessels in the entire body. In most mammalian systems, the capacity of endothelial cells to divide is limited and endothelial cells are prone to be senescent. Aging of ECs and resultant endothelial dysfunction lead to a variety of vascular diseases such as atherosclerosis, diabetes mellites, hypertension, and ischemic injury. However, the mechanism by which ECs get old and become senescent and the impact of endothelial senescence on the vascular function are not fully understood. Recent research has unveiled the crucial roles of miRNAs, which are small non-coding RNAs, in regulating endothelial cellular functions, including nitric oxide production, vascular inflammation, and anti-thromboformation. In this review, how senescent-related miRNAs are involved in controlling the functions of ECs will be discussed. View Full-Text
Keywords: microRNA; Endothelial cells; Senescence; SIRT1 microRNA; Endothelial cells; Senescence; SIRT1
Show Figures

Figure 1

MDPI and ACS Style

Yamakuchi, M.; Hashiguchi, T. Endothelial Cell Aging: How miRNAs Contribute? J. Clin. Med. 2018, 7, 170.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop