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Endothelial Cell Aging: How miRNAs Contribute?

Department of Laboratory and Vascular Medicine, Cardiovascular and Respiratory Disorders, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1, Sakuragaoka, Kagoshima 890-8520, Japan
Author to whom correspondence should be addressed.
J. Clin. Med. 2018, 7(7), 170;
Received: 15 June 2018 / Revised: 4 July 2018 / Accepted: 9 July 2018 / Published: 10 July 2018
(This article belongs to the Section Molecular Medicine)
Endothelial cells (ECs) form monolayers and line the interior surfaces of blood vessels in the entire body. In most mammalian systems, the capacity of endothelial cells to divide is limited and endothelial cells are prone to be senescent. Aging of ECs and resultant endothelial dysfunction lead to a variety of vascular diseases such as atherosclerosis, diabetes mellites, hypertension, and ischemic injury. However, the mechanism by which ECs get old and become senescent and the impact of endothelial senescence on the vascular function are not fully understood. Recent research has unveiled the crucial roles of miRNAs, which are small non-coding RNAs, in regulating endothelial cellular functions, including nitric oxide production, vascular inflammation, and anti-thromboformation. In this review, how senescent-related miRNAs are involved in controlling the functions of ECs will be discussed. View Full-Text
Keywords: microRNA; Endothelial cells; Senescence; SIRT1 microRNA; Endothelial cells; Senescence; SIRT1
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Yamakuchi, M.; Hashiguchi, T. Endothelial Cell Aging: How miRNAs Contribute? J. Clin. Med. 2018, 7, 170.

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