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Open AccessArticle

Investigation on the Use of Traditional Chinese Medicine for Polycystic Ovary Syndrome in a Nationwide Prescription Database in Taiwan

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Graduate Institute of Chinese Medicine, School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung 404 Taiwan
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Department of Chinese Medicine, Show Chwan Memorial Hospital, Changhua 500, Taiwan
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Management Office for Health Data, China Medical University Hospital, Taichung 404, Taiwan
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College of Medicine, China Medical University, Taichung 404, Taiwan
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Research Assistant Center, Show Chwan Memorial Hospital, Changhua 500, Taiwan
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Post Baccalaureate Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
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Department of Chinese Medicine, China Medical University Hospital, Taichung 404, Taiwan
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Research Center for Traditional Chinese Medicine, Department of Medical Research, China Medical University Hospital, Taichung 404, Taiwan
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Research Center for Chinese Herbal Medicine, China Medical University, Taichung 404, Taiwan
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Chinese Medicine Research Center, China Medical University, Taichung 404, Taiwan
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Department of Biotechnology, Asia University, Taichung 413, Taiwan
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Author to whom correspondence should be addressed.
J. Clin. Med. 2018, 7(7), 179; https://doi.org/10.3390/jcm7070179
Received: 28 June 2018 / Revised: 12 July 2018 / Accepted: 19 July 2018 / Published: 22 July 2018
(This article belongs to the Section Obstetrics & Gynecology)
Polycystic ovary syndrome (PCOS) is a common condition, affecting 5–10% of women of reproductive age worldwide. It has serious reproductive implications and causes mood disorders and metabolic disorders, such as type-2 diabetes. Because PCOS reflects multiple abnormalities, there is no single drug that can treat all its symptoms. Existing pharmaceutical agents, such as oral contraceptives (OCs), are suggested as a first-line therapy for menstrual irregularities; however, OCs are not appropriate for women pursuing pregnancy. Additionally, insulin-sensitizing agents, which appear to decrease insulin levels and hyperandrogenemia in women with PCOS, have been associated with a high incidence of gastrointestinal adverse effects. It is a common practice in Chinese society to receive traditional Chinese medicine (TCM) for treatment of gynecological problems and infertility. Current research demonstrates that several herbs and herbal formulas show beneficial effects in PCOS treatment. In this study, we conducted the first large-scale survey through the Taiwan National Health Insurance Program database to analyze TCM utilization patterns among women with PCOS in Taiwan during 1997–2010. The survey results revealed that 89.22% women with newly diagnosed PCOS had received TCM therapy. Jia-Wei-Xiao-Yao-San and Xiang-Fu (Rhizoma Cyperi) were the most commonly used formula and single herb, respectively, in the database. In addition, we found that the top five commonly prescribed single herbs and herbal formulas have shown promise in treating symptoms associated with PCOS. View Full-Text
Keywords: Polycystic ovary syndrome; traditional Chinese medicine; Jia-Wei-Xiao-Yao-San Polycystic ovary syndrome; traditional Chinese medicine; Jia-Wei-Xiao-Yao-San
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Liao, W.-T.; Chiang, J.-H.; Li, C.-J.; Lee, M.-T.; Su, C.-C.; Yen, H.-R. Investigation on the Use of Traditional Chinese Medicine for Polycystic Ovary Syndrome in a Nationwide Prescription Database in Taiwan. J. Clin. Med. 2018, 7, 179.

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