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Journal of Clinical Medicine, Volume 13, Issue 5

March-1 2024 - 338 articles

Cover Story: Sepsis is a potentially lethal medical condition with a time-sensitive window for treatment. Distinguishing between sepsis and non-infectious causes of systemic inflammation can be clinically challenging, especially early in illness when no site of infection or pathogen has been identified, and organ damage is not yet evident. SeptiCyte RAPID, a US FDA-cleared host-response gene-expression assay, is an aid for diagnosing sepsis. SeptiCyte RAPID discriminates between sepsis and non-infectious systemic inflammation with an area under the receiver operating a characteristic curve of 0.82–0.95 (depending upon cohort) and provides a probability of sepsis within 60 minutes.This study suggests that SeptiCyte RAPID alone, or when combined with commonly used demographic, clinical, or laboratory variables, can contribute clinical utility for the early identification of sepsis. View this paper
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Articles (338)

  • Article
  • Open Access
1 Citations
3,387 Views
13 Pages

Integra® Dermal Regeneration Template in Complex Scalp Reconstruction

  • Natalie Turton,
  • Aaina Aggarwal,
  • Eoin Twohig,
  • James Gallagher,
  • Kieron McVeigh,
  • Neal Barnard and
  • Karl Payne

6 March 2024

Background/Objectives: The need for surgical reconstruction of scalp defects following the excision of cutaneous skin cancers is an increasingly common procedure. Particular challenges arise when considering options for reconstruction of large defect...

  • Opinion
  • Open Access
2 Citations
4,265 Views
11 Pages

Prolongated Activated Partial Thromboplastin Time (aPTT) in Pediatric Patients before Surgery—Crying Wolf: Lupus (Anticoagulant) Does Not Always Threaten Children

  • Tiziano Martini,
  • Rita Carlotta Santoro,
  • Laura Banov,
  • Antonella Ierardi,
  • Marzia Leotta,
  • Alessandra Strangio,
  • Johanna Svahn and
  • Angelo Claudio Molinari

6 March 2024

A prolonged preoperatory aPTT in children is often the cause of a delay of scheduled surgeries and the repetition of multiple blood tests, with the consequent wasting of resources and significant discomfort for children and parents. The aim of this r...

  • Review
  • Open Access
3 Citations
4,811 Views
9 Pages

Congenital Optic Disc Anomalies: Insights from Multimodal Imaging

  • Gilda Cennamo,
  • Michele Rinaldi,
  • Marina Concilio and
  • Ciro Costagliola

6 March 2024

In this comprehensive review, we delve into the significance of multimodal imaging in diagnosing and managing complications of congenital optic disc anomalies. While the fundus examination is the gold standard tool in the diagnosis of these pathologi...

  • Review
  • Open Access
12 Citations
4,399 Views
45 Pages

5 March 2024

Background: Aging is a key risk factor for atherosclerosis progression that is associated with increased incidence of ischemic events in supplied organs, including stroke, coronary events, limb ischemia, or renal failure. Cardiovascular disease is th...

  • Systematic Review
  • Open Access
5 Citations
4,763 Views
18 Pages

The Diagnostic Accuracy of Transcranial Color-Coded Doppler Ultrasound Technique in Stratifying Intracranial Cerebral Artery Stenoses in Cerebrovascular Disease Patients: A Systematic Review and Meta-Analysis

  • Simon Takadiyi Gunda,
  • Jerica Hiu-Yui Yip,
  • Veronica Tsam-Kit Ng,
  • Ziman Chen,
  • Xinyang Han,
  • Xiangyan Chen,
  • Marco Yiu-Chung Pang and
  • Michael Tin-Cheung Ying

5 March 2024

The early and accurate stratification of intracranial cerebral artery stenosis (ICAS) is critical to inform treatment management and enhance the prognostic outcomes in patients with cerebrovascular disease (CVD). Digital subtraction angiography (DSA)...

  • Systematic Review
  • Open Access
19 Citations
11,349 Views
15 Pages

5 March 2024

Background: Early-onset myopia increases the risk of irreversible high myopia. Methods: This study systematically evaluated the efficacy and safety of low-dose atropine for myopia control in children with premyopia through meta-analysis using random-...

  • Review
  • Open Access
33 Citations
22,722 Views
18 Pages

5 March 2024

The management of mechanical ventilation (MV) remains a challenge in intensive care units (ICUs). The digitalization of healthcare and the implementation of artificial intelligence (AI) and machine learning (ML) has significantly influenced medical d...

  • Perspective
  • Open Access
5 Citations
4,588 Views
11 Pages

5 March 2024

A very low incidence of acute kidney injury (AKI) has been observed in COVID-19 patients purposefully treated with early pressure support ventilation (PSV) compared to those receiving mainly controlled ventilation. The prevention of subdiaphragmatic...

  • Feature Paper
  • Article
  • Open Access
3 Citations
2,855 Views
12 Pages

Outcomes of “Over the Top” Anterior Cruciate Ligament Reconstruction Associated with a Lateral Extra-Articular Tenodesis in Children

  • Abel Gomez-Caceres,
  • Iskandar Tamimi-Mariño,
  • Francisco Javier Martinez-Malo,
  • Raphael Pierre Idiart-Charrier,
  • Ignacio Vieitez-Riestra and
  • Ivan Medina-Porqueres

5 March 2024

(1) Purpose: The incidence of anterior cruciate ligament (ACL) ruptures in children and adolescents has considerably increased during the last decades due to higher levels of competitive athletic activity, and early sport specialization and professio...

  • Systematic Review
  • Open Access
18 Citations
7,190 Views
14 Pages

Bone Remodeling of Maxilla after Retraction of Incisors during Orthodontic Treatment with Extraction of Premolars Based on CBCT Study: A Systematic Review

  • Anna Ewa Kuc,
  • Jacek Kotuła,
  • Jakub Nawrocki,
  • Maria Kulgawczyk,
  • Beata Kawala,
  • Joanna Lis and
  • Michał Sarul

5 March 2024

Background: Incisor retraction is often a crucial phase in ongoing orthodontic treatment, with significant implications for alveolar remodeling mechanisms. There are two prevailing theories which seek to explain this. According to the first, teeth mo...

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J. Clin. Med. - ISSN 2077-0383