Inflammation in Neuro-Oncological Diseases and in Neuro-Vascular Diseases

Abstract submission deadline

closed (31 December 2023)

Manuscript submission deadline

closed (31 March 2024)

Viewed by

16921

Topic Information

Dear Colleagues,

Neuroinflammation plays an essential role in tumorigenesis, malignant progression, vascular inflammation, and clinical symptomatology. The central nervous system (CNS) microenvironment has a significant role in those pathophysiological processes. Interleukins, immune infiltrates, cyclooxygenases, etc. are important drivers in those diseases. On a cellular basis, tumor-associated macrophages, reactive astrocytes, leukocytes, platelets, and further contributors of the inflammatory response influence diseases’ progression and response to treatment. Several preclinical and clinical trials investigating neuroinflammation and pharmacological modulation of the immune system have improved our understanding of the immune response in neuro-oncological and neurovascular diseases. This Topic Issue will focus on preclinical and clinical data regarding the interaction between neuro-oncological or neurovascular diseases and neuroinflammation.

Prof. Dr. Erdem Güresir
Dr. Johannes Wach
Dr. Martin Vychopen
Topic Editors

Keywords

Participating Journals

Journal Name	Impact Factor	CiteScore	Launched Year	First Decision (median)	APC
Brain Sciences brainsci	2.7	4.8	2011	15.6 Days	CHF 2200
Cancers cancers	4.5	8.0	2009	17.4 Days	CHF 2900
Journal of Clinical Medicine jcm	3.0	5.7	2012	16 Days	CHF 2600
Journal of Vascular Diseases jvd	-	-	2022	23.3 Days	CHF 1000
Neurology International neurolint	3.2	3.7	2009	26.5 Days	CHF 1600

Preprints.org is a multidisciplinary platform offering a preprint service designed to facilitate the early sharing of your research. It supports and empowers your research journey from the very beginning.

MDPI Topics is collaborating with Preprints.org and has established a direct connection between MDPI journals and the platform. Authors are encouraged to take advantage of this opportunity by posting their preprints at Preprints.org prior to publication:

1. Share your research immediately: disseminate your ideas prior to publication and establish priority for your work.
2. Safeguard your intellectual contribution: Protect your ideas with a time-stamped preprint that serves as proof of your research timeline.
3. Boost visibility and impact: Increase the reach and influence of your research by making it accessible to a global audience.
4. Gain early feedback: Receive valuable input and insights from peers before submitting to a journal.
5. Ensure broad indexing: Web of Science (Preprint Citation Index), Google Scholar, Crossref, SHARE, PrePubMed, Scilit and Europe PMC.

Published Papers (6 papers)

Order results

Content type Publication Date

Result details

Normal Extended Compact

Journals

All Brain Sciences Cancers JCM JVD Neurology International

Show export options expand_more Show export options expand_less

Select all

Export citation of selected articles as:

Plain Text BibTeX BibTeX (without abstracts) Endnote Endnote (without abstracts) Tab-delimited RIS

Error

Oops... you haven't selected anything for export.

Ok

clear

23 pages, 11528 KiB  

Open AccessReview

Neurovascular Issues in Antiphospholipid Syndrome: Arterial Vasculopathy from Small to Large Vessels in a Neuroradiological Perspective

by Marialuisa Zedde, Ilaria Grisendi, Federica Assenza, Manuela Napoli, Claudio Moratti, Bonacini Lara, Giovanna Di Cecco, Serena D’Aniello, Claudio Pavone, Francesca Romana Pezzella, Paolo Candelaresi, Vincenzo Andreone, Franco Valzania and Rosario Pascarella

J. Clin. Med. 2024, 13(13), 3667; https://doi.org/10.3390/jcm13133667 - 24 Jun 2024

Viewed by 2897

Abstract

Antiphospholipid syndrome (APS) is an autoimmune prothrombotic condition characterized by venous thromboembolism, arterial thrombosis, and pregnancy morbidity. Among neurological manifestations, arterial thrombosis is only one of the possible associated clinical and neuroradiological features. The aim of this review is to address from a [...] Read more.

Antiphospholipid syndrome (APS) is an autoimmune prothrombotic condition characterized by venous thromboembolism, arterial thrombosis, and pregnancy morbidity. Among neurological manifestations, arterial thrombosis is only one of the possible associated clinical and neuroradiological features. The aim of this review is to address from a neurovascular point of view the multifaceted range of the arterial side of APS. A modern neurovascular approach was proposed, dividing the CNS involvement on the basis of the size of affected arteries, from large to small arteries, and corresponding clinical and neuroradiological issues. Both large-vessel and small-vessel involvement in APS were detailed, highlighting the limitations of the available literature in the attempt to derive some pathomechanisms. APS is a complex disease, and its neurological involvement appears multifaceted and not yet fully characterized, within and outside the diagnostic criteria. The involvement of intracranial large and small vessels appears poorly characterized, and the overlapping with the previously proposed inflammatory manifestations is consistent. Full article

(This article belongs to the Topic Inflammation in Neuro-Oncological Diseases and in Neuro-Vascular Diseases)

►▼ Show Figures

Figure 1

15 pages, 751 KiB  

Open AccessReview

Microglia in Glioblastomas: Molecular Insight and Immunotherapeutic Potential

by Sabrina Nusraty, Ujwal Boddeti, Kareem A. Zaghloul and Desmond A. Brown

Cancers 2024, 16(11), 1972; https://doi.org/10.3390/cancers16111972 - 22 May 2024

Cited by 2 | Viewed by 1871

Abstract

Glioblastoma (GBM) is one of the most aggressive and devastating primary brain tumors, with a median survival of 15 months following diagnosis. Despite the intense treatment regimen which routinely includes maximal safe neurosurgical resection followed by adjuvant radio- and chemotherapy, the disease remains [...] Read more.

Glioblastoma (GBM) is one of the most aggressive and devastating primary brain tumors, with a median survival of 15 months following diagnosis. Despite the intense treatment regimen which routinely includes maximal safe neurosurgical resection followed by adjuvant radio- and chemotherapy, the disease remains uniformly fatal. The poor prognosis associated with GBM is multifactorial owing to factors such as increased proliferation, angiogenesis, and metabolic switching to glycolytic pathways. Critically, GBM-mediated local and systemic immunosuppression result in inadequate immune surveillance and ultimately, tumor-immune escape. Microglia—the resident macrophages of the central nervous system (CNS)—play crucial roles in mediating the local immune response in the brain. Depending on the specific pathological cues, microglia are activated into either a pro-inflammatory, neurotoxic phenotype, known as M1, or an anti-inflammatory, regenerative phenotype, known as M2. In either case, microglia secrete corresponding pro- or anti-inflammatory cytokines and chemokines that either promote or hinder tumor growth. Herein, we review the interplay between GBM cells and resident microglia with a focus on contemporary studies highlighting the effect of GBM on the subtypes of microglia expressed, the associated cytokines/chemokines secreted, and ultimately, their impact on tumor pathogenesis. Finally, we explore how understanding the intricacies of the tumor-immune landscape can inform novel immunotherapeutic strategies against this devastating disease. Full article

(This article belongs to the Topic Inflammation in Neuro-Oncological Diseases and in Neuro-Vascular Diseases)

►▼ Show Figures

Figure 1

9 pages, 443 KiB  

Open AccessReview

Congenital Optic Disc Anomalies: Insights from Multimodal Imaging

by Gilda Cennamo, Michele Rinaldi, Marina Concilio and Ciro Costagliola

J. Clin. Med. 2024, 13(5), 1509; https://doi.org/10.3390/jcm13051509 - 6 Mar 2024

Cited by 3 | Viewed by 2842

Abstract

In this comprehensive review, we delve into the significance of multimodal imaging in diagnosing and managing complications of congenital optic disc anomalies. While the fundus examination is the gold standard tool in the diagnosis of these pathologies, spectral domain (SD) optical coherence tomography [...] Read more.

In this comprehensive review, we delve into the significance of multimodal imaging in diagnosing and managing complications of congenital optic disc anomalies. While the fundus examination is the gold standard tool in the diagnosis of these pathologies, spectral domain (SD) optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) could shed light on the pathogenesis and treatment. Moreover, this review seeks to offer a comprehensive insight into the multimodal approach of these rare congenital pathologies. In conclusion, congenital anomalies of the optic nerve represent a major challenge for ophthalmologists. Further research could be useful to clarify the pathophysiology of these diseases and define a correct and more specific treatment approach. Full article

(This article belongs to the Topic Inflammation in Neuro-Oncological Diseases and in Neuro-Vascular Diseases)

►▼ Show Figures

Figure 1

13 pages, 266 KiB  

Open AccessArticle

Neutrophil–Lymphocyte Ratio as a Predictor of Cerebral Small Vessel Disease in a Geriatric Community: The I-Lan Longitudinal Aging Study

by Shao-Yuan Chuang, Yin-Chen Hsu, Kuang-Wei Chou, Kuo-Song Chang, Chiong-Hee Wong, Ya-Hui Hsu, Hao-Min Cheng, Chien-Wei Chen and Pang-Yen Chen

Brain Sci. 2023, 13(7), 1087; https://doi.org/10.3390/brainsci13071087 - 18 Jul 2023

Cited by 6 | Viewed by 3207

Abstract

Cerebral Small Vessel Disease (CSVD) frequently affects the elderly, with inflammation playing a crucial role in related health complications, including dementia, stroke, and SVD. Studies, including animal experiments, indicate a strong link between inflammation and SVD progression. The Neutrophil-Lymphocyte Ratio (NLR) serves as [...] Read more.

Cerebral Small Vessel Disease (CSVD) frequently affects the elderly, with inflammation playing a crucial role in related health complications, including dementia, stroke, and SVD. Studies, including animal experiments, indicate a strong link between inflammation and SVD progression. The Neutrophil-Lymphocyte Ratio (NLR) serves as a possible biomarker for ongoing inflammatory risks. A total of 720 adults aged 50 years or older from the community-based I-Lan Longitudinal Aging Study were included in this study. General linear regression and ordinally logistic regression analyses were performed to evaluate the association between NLR and CSVD. We further examined the presence of lacune, microbleed, and white matter hyperintensity (WMH) on brain MRI, which were used to construct a combined CSVD score. The NLR was positively associated with WMH (adjusted r = 0.109, p = 0.003), microbleed (adjusted r = 0.102, p = 0.006), and lacune (adjusted r = 0.100, p = 0.008). After adjustments for smoking, drinking, and physical activity in the ordinal logistic regression analysis, age, gender, brachial Systolic Blood Pressure (SBP), fasting glucose, LDL-cholesterol, and Hs-CRP were compared among subjects with low tertile (T1), medium tertile (T2) and high tertile (T3) NLR. The results showed that T2 vs. T1 had an odds ratio of 1.23 (0.86–1.77); and T3 vs. T1 had an odds ratio of 1.87 (1.29–2.71) of CSVD scores in four groups (zero (reference group), one, two, and three or more). NLR could be used to assess the state of inflammation in cerebral vessels. A significant and positive correlation between NLR and CSVD was verified in this study. However, the practical clinical application of NLR in CSVD patients and prognosis prediction should be validated through more scientific attempts. Full article

(This article belongs to the Topic Inflammation in Neuro-Oncological Diseases and in Neuro-Vascular Diseases)

attachment

Supplementary material:
Supplementary File 1 (ZIP, 1163 KiB)

15 pages, 2135 KiB  

Open AccessArticle

Prognostic Value of Systemic Immune-Inflammation Index (SII) in Patients with Glioblastoma: A Comprehensive Study Based on Meta-Analysis and Retrospective Single-Center Analysis

by Chao Yang, Bo-Wen Hu, Feng Tang, Qing Zhang, Wei Quan, Jie Wang, Ze-Fen Wang, Yi-Rong Li and Zhi-Qiang Li

J. Clin. Med. 2022, 11(24), 7514; https://doi.org/10.3390/jcm11247514 - 19 Dec 2022

Cited by 14 | Viewed by 2588

Abstract

Inflammation is related to cancer. The systemic immune-inflammation index (SII) has been linked to the prognosis of many types of cancer. The present study aimed to determine the prognostic value of the SII in glioblastoma (GBM) patients based on meta-analysis and single-center retrospective [...] Read more.

Inflammation is related to cancer. The systemic immune-inflammation index (SII) has been linked to the prognosis of many types of cancer. The present study aimed to determine the prognostic value of the SII in glioblastoma (GBM) patients based on meta-analysis and single-center retrospective analysis. Relevant publications published before 1 October 2022 were identified by searching PubMed, EMBASE, Cochrane Library databases, and Web of Science. Moreover, 208 GBM patients from Zhongnan Hospital were incorporated. Kaplan–Meier and Cox regression analyses determined the prognostic significance of inflammatory markers. By combining these indicators, we developed scoring systems. Nomograms were also built by incorporating independent variables. The accuracies of nomograms were evaluated by Harrell’s concordance index (c-index) and the calibration curve. According to meta-analysis, an elevated SII predicted the worst overall survival (OS) (Hazard ratio [HR] = 1.87, p < 0.001). Furthermore, a higher SII (>510.8) (HR = 1.782, p = 0.007) also predicted a poorer outcome in a retrospective cohort. The scoring systems of SII-NLR (neutrophil-to-lymphocyte ratio) showed the best predictive power for OS. The nomogram without MGMT (c-index = 0.843) exhibited a similar accuracy to that with MGMT (c-index = 0.848). A pre-treatment SII is independently associated with OS in GBM. A nomogram integrating the SII-NLR score may facilitate a comprehensive survival evaluation independent of molecular tests in GBM. Full article

(This article belongs to the Topic Inflammation in Neuro-Oncological Diseases and in Neuro-Vascular Diseases)

►▼ Show Figures

Figure 1

12 pages, 1489 KiB  

Open AccessArticle

The Effect of Losartan on Neuroinflammation as Well as on Endothelin-1- and Serotonin-Induced Vasoconstriction in a Double-Haemorrhage Rat Model

by Jürgen Konczalla, Jan Mrosek, Sepide Kashefiolasl, Christian Musahl, Serge Marbacher, Gerrit Alexander Schubert, Lukas Andereggen and Stefan Wanderer

J. Clin. Med. 2022, 11(24), 7367; https://doi.org/10.3390/jcm11247367 - 12 Dec 2022

Cited by 1 | Viewed by 1630

Abstract

Poor patient outcome after aneurysmal subarachnoid haemorrhage (SAH) is due to a multifactorial process. Delayed cerebral vasospasm, ischemic neurological deficits, and infarction are the most feared acute sequelae triggered by enhanced synthesis of serotonin and endothelin-1 (ET-1). During the past decades, multiple drugs [...] Read more.

Poor patient outcome after aneurysmal subarachnoid haemorrhage (SAH) is due to a multifactorial process. Delayed cerebral vasospasm, ischemic neurological deficits, and infarction are the most feared acute sequelae triggered by enhanced synthesis of serotonin and endothelin-1 (ET-1). During the past decades, multiple drugs have been analysed for protective effects without resounding success. Therefore, the authors wanted to analyse the potential beneficial role of Losartan (LOS). Male Sprague Dawley rats were randomised into either a group receiving two injections of blood into the cisterna magna (SAH group) or a group receiving two injections of isotonic sodium chloride (sham group). The animals were culled on day five and basilar artery ring segments were used for in vitro tension studies. Sarafotoxin S6c caused a dose-dependent vasorelaxation in sham and SAH segments, which was more pronounced in sham segments. LOS, applied in a concentration of 10⁻³ M, was able to significantly reduce serotonin- (p < 0.01) and ET-1- (p < 0.05, p < 0.01) mediated vasoconstriction in sham segments. These findings, along with the well-known beneficial effects of LOS on restoring the impaired endothelin-B₁-receptor function after SAH, as well as on the neuroprotectional and antiepileptogenic aspects, might be implemented in advancing tailored concepts to sufficiently ameliorate patients’ functional outcome after SAH. Full article

(This article belongs to the Topic Inflammation in Neuro-Oncological Diseases and in Neuro-Vascular Diseases)

►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less

Select all

Export citation of selected articles as:

Plain Text BibTeX BibTeX (without abstracts) Endnote Endnote (without abstracts) Tab-delimited RIS

 

Error

Oops... you haven't selected anything for export.

Ok

clear

Displaying articles 1-6