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Journal of Clinical Medicine, Volume 10, Issue 5

March-1 2021 - 256 articles

Cover Story: Immune thrombocytopenia (ITP) results from a peripheral platelet destruction and an inappropriate bone marrow production. Recent advances have highlighted the multiple pathways involved in ITP pathogenesis such as antibody-dependent cell phagocytosis, complement dependent cytotoxicity, CD8 T cell mediated cytotoxicity, platelet desialylation and insufficient production of thrombopoietin. New upcoming therapies which specifically target one or multiple mechanisms involved in ITP, such as Syk inhibitors, IgG Fc receptor (FcγR) inhibitors, complement inhibitors and neonatal Fc receptor (FcRn) blockers are about to deeply modify the management of ITP, currently based on corticosteroids, intravenous immunoglobulins, thrombopoietin receptor agonists, immunosuppressants and splenectomy. View this paper
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Articles (256)

  • Article
  • Open Access
7 Citations
2,983 Views
13 Pages
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Acute Management Should Be Optimized in Patients with Less Specific Stroke Symptoms: Findings from a Retrospective Observational Study

  • Simona Halúsková,
  • Roman Herzig,
  • Dagmar Krajíčková,
  • Abduljabar Hamza,
  • Antonín Krajina,
  • Vendelín Chovanec,
  • Miroslav Lojík,
  • Jan Raupach,
  • Ondřej Renc and
  • Libor Šimůnek
  • + 3 authors
J. Clin. Med.2021, 10(5), 1143;https://doi.org/10.3390/jcm10051143

9 March 2021

Anterior circulation stroke (ACS) is associated with typical symptoms, while posterior circulation stroke (PCS) may cause a wide spectrum of less specific symptoms. We aim to assess the correlation between the initial presentation of acute ischemic s...

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  • Article
  • Open Access
8 Citations
3,579 Views
9 Pages
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Sleeve Gastrectomy Is Associated with a Greater Reduction in Plasma Liver Enzymes Than Bypass Surgeries—A Registry-Based Two-Year Follow-Up Analysis

  • Shira Azulai,
  • Ronit Grinbaum,
  • Nahum Beglaibter,
  • Shai Meron Eldar,
  • Moshe Rubin,
  • Rachel Ben-Haroush Schyr,
  • Orly Romano-Zelekha and
  • Danny Ben-Zvi
J. Clin. Med.2021, 10(5), 1144;https://doi.org/10.3390/jcm10051144

9 March 2021

Bariatric surgeries may lead to an improvement in metabolic fatty liver disease, and a reduction in the levels of the hepatic enzyme Alanine Aminotransferase (ALT). We compared the effects of Sleeve Gastrectomy (SG), Roux en Y Gastric Bypass (RYGB) a...

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  • Article
  • Open Access
6 Citations
4,202 Views
11 Pages
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Cancer Patients’ Prehospital Emergency Care: Post Hoc Analysis from the French Prospective Multicenter Study EPICANCER

  • Olivier Peyrony,
  • Jean-Paul Fontaine,
  • Eloïse Trabattoni,
  • Lionel Nakad,
  • Sylvain Charreyre,
  • Adrien Picaud,
  • Juliane Bosc,
  • Damien Viglino,
  • Laurent Jacquin and
  • Saïd Laribi
  • + 7 authors
J. Clin. Med.2021, 10(5), 1145;https://doi.org/10.3390/jcm10051145

9 March 2021

Background: Very little data are available concerning the prehospital emergency care of cancer patients. The objective of this study is to report the trajectories and outcomes of cancer patients attended by prehospital emergency services. Methods: Th...

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  • Article
  • Open Access
6 Citations
2,331 Views
10 Pages
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The Effect of Adding Biological Factors to the Decision-Making Process for Spinal Metastasis of Non-Small Cell Lung Cancer

  • Hyoungmin Kim,
  • Sam Yeol Chang,
  • Jongyeon Son,
  • Sujung Mok,
  • Sung Cheol Park and
  • Bong-Soon Chang
J. Clin. Med.2021, 10(5), 1119;https://doi.org/10.3390/jcm10051119

8 March 2021

Molecular target therapies have markedly improved the survival of non-small cell lung cancer (NSCLC) patients, especially those with epidermal growth factor receptor (EGFR) mutations. A positive EGFR mutation is even more critical when the chronicity...

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  • Editorial
  • Open Access
13 Citations
3,320 Views
3 Pages
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Is It Time for Machine Learning Algorithms to Predict the Risk of Kidney Failure in Patients with Chronic Kidney Disease?

  • Charat Thongprayoon,
  • Wisit Kaewput,
  • Avishek Choudhury,
  • Panupong Hansrivijit,
  • Michael A. Mao and
  • Wisit Cheungpasitporn
J. Clin. Med.2021, 10(5), 1121;https://doi.org/10.3390/jcm10051121

8 March 2021

Chronic kidney disease (CKD) is a common clinical problem affecting more than 800 million people with different kidney diseases [...]

Full Article
  • Review
  • Open Access
74 Citations
6,977 Views
14 Pages
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The Role of Extracellular Matrix Components in Inflammatory Bowel Diseases

  • Alicja Derkacz,
  • Paweł Olczyk,
  • Krystyna Olczyk and
  • Katarzyna Komosinska-Vassev
J. Clin. Med.2021, 10(5), 1122;https://doi.org/10.3390/jcm10051122

8 March 2021

The remodeling of extracellular matrix (ECM) within the intestine tissues, which simultaneously involves an increased degradation of ECM components and excessive intestinal fibrosis, is a defining trait of the progression of inflammatory bowel diseas...

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  • Article
  • Open Access
3 Citations
2,986 Views
10 Pages
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High Cortico-Trabecular Transitional Zone Porosity and Reduced Trabecular Density in Men and Women with Stress Fractures

  • Afrodite Zendeli,
  • Minh Bui,
  • Lukas Fischer,
  • Ali Ghasem-Zadeh,
  • Wolfgang Schima and
  • Ego Seeman
J. Clin. Med.2021, 10(5), 1123;https://doi.org/10.3390/jcm10051123

8 March 2021

To determine whether stress fractures are associated with bone microstructural deterioration we quantified distal radial and the unfractured distal tibia using high resolution peripheral quantitative computed tomography in 26 cases with lower limb st...

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  • Article
  • Open Access
3 Citations
2,462 Views
17 Pages
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Polymorphisms in the Gene Encoding Caspase 8 May Predict the Response to First-Line Platinum-Based Chemotherapy in Locally Advanced or Advanced Non-Small-Cell Lung Cancer

  • Michał Szczyrek,
  • Radosław Mlak,
  • Aneta Szudy-Szczyrek,
  • Karolina Kędziora,
  • Teresa Małecka-Massalska,
  • Paweł Krawczyk and
  • Janusz Milanowski
J. Clin. Med.2021, 10(5), 1126;https://doi.org/10.3390/jcm10051126

8 March 2021

Caspase 8 is a protein involved in the process of cell apoptosis, which may affect the efficacy of anti-cancer treatment. The aim of our study was to determine the impact of polymorphisms in the CASP-8 gene encoding caspase 8 on the prognosis in non-...

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J. Clin. Med. - ISSN 2077-0383
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