Thrombolysis and Thrombectomy in Acute Ischemic Stroke

Dear Colleagues,

Previously, intravenous tissue plasminogen activator (IV tPA) within 4.5 h of stroke onset was the only therapy for acute ischemic stroke. However, the recanalization rate of IV tPA is not satisfactory. After successful randomized clinical trials, endovascular thrombectomy (EVT) has been a standard of care for patients with acute ischemic stroke due to large artery occlusion within 6 h of onset. Guidelines still recommend that patients eligible for IV tPA should receive IV tPA even if EVTs are being considered. Recently, two randomized clinical trials demonstrated that EVT, even in the late time window of up to 16 or 24 h after the last known normal time. Expanding the time window of EVT up to 24 h would have a significant impact on the stroke care system. Many researchers have conducted numerous studies to search for more effective treatments, evaluation tools, and efficient care pathways.

This Special Issue of the Journal of Clinical Medicine will cover the following important aspects of IV thrombolysis and EVT in acute ischemic stroke:

Prehospital stroke management;

In-hospital or interhospital care system;

Acute brain imaging;

Emergency evaluation and treatment;

Intravenous thrombolysis;

Endovascular thrombectomy;

Patient care after IV tPA and EVT;

Outcome predictors of reperfusion therapy.

Prof. Dr. Hyo Suk Nam
Prof. Dr. Byung Moon Kim
Guest Editors

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