Special Issue "Infrequent Lipodystrophies: Challenges in Pathogenesis, Diagnosis and Treatment"
Deadline for manuscript submissions: closed (28 February 2021).
Interests: Infrequent lipodystrophies; Adipose tissue; Laminopathies; Seipinopathies; Neurodegeneration; Diabetes mellitus; Transgenic mice; Insulin resistance
Lipodystrophies are a heterogeneous set of clinical entities, which, with the exception of that associated with AIDS, have a very low prevalence. On the other hand, its etiology is diverse, and may be congenital or acquired. Among the familiar subtypes, more than 30 causal genes have been described to date; and among the acquired forms, some have been related to autoimmune processes. Therefore, they are disorders with complex and different pathogenetic mechanisms, and in many cases little or nothing known. Added to all this is a great phenotypic variability that, associated with its low prevalence, makes diagnosis a challenge for physicians, including pediatricians and endocrinologists. Lipodystrophies have no cure today, and the therapeutic approach is focused on controlling the metabolic, hepatic, and reproductive comorbidities that are often associated with these disorders.
This Special Issue welcomes articles either highlighting recent developments in or providing new experimental (in vitro or animal model) or clinical (human) data related to pathogenesis, diagnosis and treatment of infrequent lipodystrophies. We would appreciate it if the authors provided a brief section in their manuscript indicating the novelty of their findings or, in the case of review articles, provided personal views on a particular topic.
Dr. David Araújo-Vilar
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Novel Genes
- Pathogenetic Mechanisms
- Animal Models
- Diagnosis Criteria
- Therapeutical Approaches