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Journal of Clinical Medicine, Volume 10, Issue 4

February-2 2021 - 339 articles

Cover Story: The clot-stabilizing effect and downstream functionalities of coagulation factor XIII (FXIII) make it a promising target for drug development since FXIII inhibition does not significantly increase the bleeding risk. To investigate the inhibitory effect of aptamers on activated FXIII (FXIIIa), six DNA aptamers targeting FXIIIa were selected and characterized. Among all, the so-called FA12 aptamer showed inhibitoy effect on incorporation of FXIIIa and α2-antiplasmin (α2AP) to fibrin. Furthermore, FA12 reduced the clot stiffness and elasticity in ROTEM analysis when spiked to citrated plasma or whole blood. These features render FA12 as an interesting candidate molecule for the development of FXIIIa-targeting therapeutic strategies. View this paper
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Articles (339)

  • Article
  • Open Access
13 Citations
5,208 Views
18 Pages

Spinal Cord Morphology in Degenerative Cervical Myelopathy Patients; Assessing Key Morphological Characteristics Using Machine Vision Tools

  • Kalum Ost,
  • W. Bradley Jacobs,
  • Nathan Evaniew,
  • Julien Cohen-Adad,
  • David Anderson and
  • David W. Cadotte

23 February 2021

Despite Degenerative Cervical Myelopathy (DCM) being the most common form of spinal cord injury, effective methods to evaluate patients for its presence and severity are only starting to appear. Evaluation of patient images, while fast, is often unre...

  • Review
  • Open Access
50 Citations
8,352 Views
23 Pages

Cold Atmospheric Plasma: A New Strategy Based Primarily on Oxidative Stress for Osteosarcoma Therapy

  • Miguel Mateu-Sanz,
  • Juan Tornín,
  • Maria-Pau Ginebra and
  • Cristina Canal

23 February 2021

Osteosarcoma is the most common primary bone tumor, and its first line of treatment presents a high failure rate. The 5-year survival for children and teenagers with osteosarcoma is 70% (if diagnosed before it has metastasized) or 20% (if spread at t...

  • Review
  • Open Access
24 Citations
9,740 Views
17 Pages

Pearls and Pitfalls of Introducing Ketogenic Diet in Adult Status Epilepticus: A Practical Guide for the Intensivist

  • Jason B. Katz,
  • Kent Owusu,
  • Ilisa Nussbaum,
  • Rachel Beekman,
  • Nicholas A. DeFilippo,
  • Emily J. Gilmore,
  • Lawrence J. Hirsch,
  • Mackenzie C. Cervenka and
  • Carolina B. Maciel

22 February 2021

Background: Status epilepticus (SE) carries an exceedingly high mortality and morbidity, often warranting an aggressive therapeutic approach. Recently, the implementation of a ketogenic diet (KD) in adults with refractory and super-refractory SE has...

  • Review
  • Open Access
25 Citations
7,972 Views
15 Pages

Pharmacological Management of Neurogenic Bowel Dysfunction after Spinal Cord Injury and Multiple Sclerosis: A Systematic Review and Clinical Implications

  • Jeffery S Johns,
  • Klaus Krogh,
  • Karen Ethans,
  • Joanne Chi,
  • Matthew Querée,
  • Janice J Eng and
  • Spinal Cord Injury Research Evidence Team

22 February 2021

Neurogenic bowel dysfunction (NBD) is a common problem for people with spinal cord injury (SCI) and multiple sclerosis (MS), which seriously impacts quality of life. Pharmacological management is an important component of conservative bowel managemen...

  • Retraction
  • Open Access
4 Citations
2,474 Views
1 Page

22 February 2021

The journal retracts the article “Platypnea-Orthodeoxia Syndrome: Multiple Pathophysiological Interpretations of a Clinical Picture Primarily Consisting of Orthostatic Dyspnea” by De Vecchis, R [...]

  • Article
  • Open Access
22 Citations
5,939 Views
14 Pages

Tear Film Break-Up Time and Dry Eye Disease Severity in a Large Norwegian Cohort

  • Mazyar Yazdani,
  • Jørgen Fiskådal,
  • Xiangjun Chen,
  • Øygunn A. Utheim,
  • Sten Ræder,
  • Valeria Vitelli and
  • Tor P. Utheim

22 February 2021

This study evaluated to what extent tear film break-up time (TFBUT) could discriminate pathological scores for other clinical tests and explore the associations between them. Dry eye patients (n = 2094) were examined for ocular surface disease index...

  • Article
  • Open Access
1 Citations
2,751 Views
11 Pages

22 February 2021

During the coronavirus disease 2019 (COVID-19) pandemic, many guidelines have recommended postponing non-emergency operations. However, cesarean sections cannot be indefinitely delayed. Our institution has established a COVID-19 screening strategy fo...

  • Review
  • Open Access
6 Citations
3,632 Views
14 Pages

Lipid-Lowering Therapy in Patients with Coronary Heart Disease and Prior Stroke: Mission Impossible?

  • Pier Luigi Temporelli,
  • Marcello Arca,
  • Laura D’Erasmo and
  • Raffaele De Caterina

22 February 2021

Hyperlipidemia is a powerful risk factor for coronary heart disease (CHD). It has been known for a long time that lipid-lowering drugs significantly reduce morbidity from CHD, thus proving a causal role for cholesterol in coronary events. Conversely,...

  • Article
  • Open Access
4 Citations
3,091 Views
11 Pages

22 February 2021

Background. This paper aimed to prospectively evaluate the safety of embolization therapy of pulmonary arteriovenous malformations (PAVMs) for the detection of cerebral infarctions by pre- and post-interventional MRI. Method One hundred and five pati...

  • Article
  • Open Access
5 Citations
8,879 Views
10 Pages

Epidermal Barrier Function and Skin Homeostasis in Skin with Permanent and Adhesive Tattoos: A Cross-Sectional Study

  • Jose-Pablo Serrano-Serra,
  • Trinidad Montero-Vilchez,
  • Agustin Buendia-Eisman and
  • Salvador Arias-Santiago

22 February 2021

Tattoos are a current trend, but their impact on skin homeostasis and epidermal barrier function is not well known. So, the aims of this study are (1) to investigate epidermal barrier function and skin homeostasis in skin with permanent tattoos, adhe...

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J. Clin. Med. - ISSN 2077-0383