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Journal of Clinical Medicine, Volume 10, Issue 5

March-1 2021 - 256 articles

Cover Story: Immune thrombocytopenia (ITP) results from a peripheral platelet destruction and an inappropriate bone marrow production. Recent advances have highlighted the multiple pathways involved in ITP pathogenesis such as antibody-dependent cell phagocytosis, complement dependent cytotoxicity, CD8 T cell mediated cytotoxicity, platelet desialylation and insufficient production of thrombopoietin. New upcoming therapies which specifically target one or multiple mechanisms involved in ITP, such as Syk inhibitors, IgG Fc receptor (FcγR) inhibitors, complement inhibitors and neonatal Fc receptor (FcRn) blockers are about to deeply modify the management of ITP, currently based on corticosteroids, intravenous immunoglobulins, thrombopoietin receptor agonists, immunosuppressants and splenectomy. View this paper
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Articles (256)

  • Article
  • Open Access
15 Citations
6,661 Views
9 Pages

Pilot Study to Evaluate the Efficacy of Polynucleotide Sodium Compared to Sodium Hyaluronate and Crosslinked Sodium Hyaluronate in Patients with Knee Osteoarthritis

  • Ji Yeong Kim,
  • Yoo Na Kim,
  • Yu Jung Lee,
  • Sung Eun Sim,
  • Yu Ri Ko,
  • Jin Woo Shim,
  • Ku Sang Lee,
  • Mina Joo and
  • Hue Jung Park

9 March 2021

Degenerative arthritis of the knee joint has become a major social problem worldwide due to population aging. There are several treatment options for knee osteoarthritis, and the intraarticular injection of sodium hyaluronate is commonly selected by...

  • Review
  • Open Access
4 Citations
3,105 Views
12 Pages

Analysis of the Clinical and Epidemiological Meaning of Screening Test for SARS-CoV-2: Considerations in the Chronic Kidney Disease Patients during the COVID-19 Pandemic

  • Francesca Martino,
  • Gianpaolo Amici,
  • Stefano Grandesso,
  • Rosella Ferraro Mortellaro,
  • Antonina Lo Cicero and
  • Giacomo Novara

9 March 2021

The COronaVIrus Disease 19 (COVID-19) pandemic is an emerging reality in nephrology. In a continuously changing scenario, we need to assess our patients’ additional risk in terms of attending hemodialysis treatments, follow-up peritoneal dialysis, an...

  • Review
  • Open Access
30 Citations
8,257 Views
12 Pages

9 March 2021

Bisphosphonates are first-line therapy for osteoporosis, with alendronate, risedronate, and zoledronate as the main treatments used globally. After one year of therapy, bisphosphonates are retained in bone for extended periods with extended anti-frac...

  • Article
  • Open Access
34 Citations
3,662 Views
13 Pages

MCP-1 Predicts Recurrent Cardiovascular Events in Patients with Persistent Inflammation

  • Luis M. Blanco-Colio,
  • Nerea Méndez-Barbero,
  • Ana María Pello Lázaro,
  • Álvaro Aceña,
  • Nieves Tarín,
  • Carmen Cristóbal,
  • Juan Martínez-Milla,
  • Óscar González-Lorenzo,
  • José Luis Martín-Ventura and
  • Ana Huelmos
  • + 9 authors

9 March 2021

Clinical data indicate that patients with C-reactive protein (CRP) levels higher than 2 mg per liter suffer from persistent inflammation, which is associated with high risk of cardiovascular disease (CVD). We determined whether a panel of biomarkers...

  • Review
  • Open Access
24 Citations
8,509 Views
24 Pages

Efficacy of Surgery for the Treatment of Gastric Cancer Liver Metastases: A Systematic Review of the Literature and Meta-Analysis of Prognostic Factors

  • Gianpaolo Marte,
  • Andrea Tufo,
  • Francesca Steccanella,
  • Ester Marra,
  • Piera Federico,
  • Angelica Petrillo and
  • Pietro Maida

9 March 2021

Background: In the last 10 years, the management of patients with gastric cancer liver metastases (GCLM) has changed from chemotherapy alone, towards a multidisciplinary treatment with liver surgery playing a leading role. The aim of this systematic...

  • Article
  • Open Access
4 Citations
5,724 Views
12 Pages

Partial Lipodystrophy and LMNA p.R545H Variant

  • Silvia Magno,
  • Giovanni Ceccarini,
  • Andrea Barison,
  • Iacopo Fabiani,
  • Alessandro Giacomina,
  • Donatella Gilio,
  • Caterina Pelosini,
  • Anna Rubegni,
  • Michele Emdin and
  • Gian Luca Gatti
  • + 3 authors

9 March 2021

Laminopathies are disorders caused by LMNA gene mutations, which selectively affect different tissues and organ systems, and present with heterogeneous clinical and pathological traits. The molecular mechanisms behind these clinical differences and t...

  • Article
  • Open Access
7 Citations
2,974 Views
13 Pages

Acute Management Should Be Optimized in Patients with Less Specific Stroke Symptoms: Findings from a Retrospective Observational Study

  • Simona Halúsková,
  • Roman Herzig,
  • Dagmar Krajíčková,
  • Abduljabar Hamza,
  • Antonín Krajina,
  • Vendelín Chovanec,
  • Miroslav Lojík,
  • Jan Raupach,
  • Ondřej Renc and
  • Libor Šimůnek
  • + 3 authors

9 March 2021

Anterior circulation stroke (ACS) is associated with typical symptoms, while posterior circulation stroke (PCS) may cause a wide spectrum of less specific symptoms. We aim to assess the correlation between the initial presentation of acute ischemic s...

  • Article
  • Open Access
8 Citations
3,574 Views
9 Pages

Sleeve Gastrectomy Is Associated with a Greater Reduction in Plasma Liver Enzymes Than Bypass Surgeries—A Registry-Based Two-Year Follow-Up Analysis

  • Shira Azulai,
  • Ronit Grinbaum,
  • Nahum Beglaibter,
  • Shai Meron Eldar,
  • Moshe Rubin,
  • Rachel Ben-Haroush Schyr,
  • Orly Romano-Zelekha and
  • Danny Ben-Zvi

9 March 2021

Bariatric surgeries may lead to an improvement in metabolic fatty liver disease, and a reduction in the levels of the hepatic enzyme Alanine Aminotransferase (ALT). We compared the effects of Sleeve Gastrectomy (SG), Roux en Y Gastric Bypass (RYGB) a...

  • Article
  • Open Access
6 Citations
4,198 Views
11 Pages

Cancer Patients’ Prehospital Emergency Care: Post Hoc Analysis from the French Prospective Multicenter Study EPICANCER

  • Olivier Peyrony,
  • Jean-Paul Fontaine,
  • Eloïse Trabattoni,
  • Lionel Nakad,
  • Sylvain Charreyre,
  • Adrien Picaud,
  • Juliane Bosc,
  • Damien Viglino,
  • Laurent Jacquin and
  • Saïd Laribi
  • + 7 authors

9 March 2021

Background: Very little data are available concerning the prehospital emergency care of cancer patients. The objective of this study is to report the trajectories and outcomes of cancer patients attended by prehospital emergency services. Methods: Th...

  • Review
  • Open Access
28 Citations
11,366 Views
15 Pages

Ischemic Stroke and Heart Failure: Facts and Numbers. An Update

  • Anush Barkhudaryan,
  • Wolfram Doehner and
  • Nadja Scherbakov

9 March 2021

Heart failure (HF) is a severe clinical syndrome accompanied by a number of comorbidities. Ischemic stroke occurs frequently in patients with HF as a complication of the disease. In the present review, we aimed to summarize the current state of resea...

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J. Clin. Med. - ISSN 2077-0383