Vaccines, Volume 10, Issue 12
2022 December - 205 articles
Cover Story: Although heterologous prime–boost vaccinations potentially augment the immune response against SARS-CoV-2, data among liver transplant (LT) recipients are limited. We assessed humoral and cellular immune responses after primary vaccination and booster doses in LT recipients who received homologous (ChAdOx1/BNT162b2) or heterologous (ChAdOx1/ChAdOx1) vaccinations. We observed a decreased immune response three months post primary vaccination. The booster significantly improved immune responses. Most LT recipients exhibited strong immunity against the wild-type strains; however, the neutralising activity against Omicron variants was substantially lower in both groups despite the booster vaccination. Additional strategies may be required to protect against the Omicron variant in LT recipients to mitigate the ongoing SARS-CoV-2 pandemic. View this paper
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Vaccines - ISSN 2076-393X