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Vaccines, Volume 10, Issue 1

January 2022 - 135 articles

Cover Story: The process of immune-informatics-based MHC peptide vaccine design generally involves the consideration of a few relevant parameters, such as peptide binding affinity and immunogenicity. However, many vaccines that are effective in silico can fail in preclinical or clinical trials due to not accounting for other clinical properties. We have identified several clinical variables that are relevant in the design of effective peptide vaccines: binding affinity, immunogenicity, antigenicity, half-life, toxicity, IFNγ release, and instability. We developed an epitope selection method that incorporates these clinical parameters and used the method to develop an HRAS-targeting epitope vaccine for squamous cell carcinoma. This method can be widely applicable to design a durable vaccine for other diseases. View this paper
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Articles (135)

  • Article
  • Open Access
12 Citations
3,384 Views
7 Pages

COVID-19 Vaccination Willingness and Acceptability in Multiple Sclerosis Patients: A Cross Sectional Study in Iran

  • Seyed Massood Nabavi,
  • Mehrnoosh Mehrabani,
  • Leila Ghalichi,
  • Mohammad Ali Nahayati,
  • Mehran Ghaffari,
  • Fereshteh Ashtari,
  • Seyed Ehsan Mohammadianinejad,
  • Shahedeh Karimi,
  • Leila Faghani and
  • Sepideh Yazdanbakhsh
  • + 3 authors

17 January 2022

Multiple sclerosis (MS) is a chronic, predominantly immune-mediated degenerative disease of the central nervous system. Due to prolonged use of immunomodulatory and immunosuppressive medications, vaccine hesitancy could be common among MS patients. O...

  • Case Report
  • Open Access
6 Citations
5,153 Views
5 Pages

Polyneuritis Cranialis Associated with BNT162b2 mRNA COVID-19 Vaccine in a Healthy Adolescent

  • Pimchanok Kulsirichawaroj,
  • Oranee Sanmaneechai,
  • Orasri Wittawatmongkol and
  • Kulkanya Chokephaibulkit

17 January 2022

A 16-year-old Thai girl developed right facial palsy, a lower motor neuron lesion, and numbness 3 h after receiving the first dose of the BNT162b2 mRNA vaccine. Neurological examination showed the involvement of the right cranial nerves (CN) V, VII,...

  • Article
  • Open Access
20 Citations
4,175 Views
11 Pages

Antibody Levels at 3-Years Follow-Up of a Third Dose of Measles-Mumps-Rubella Vaccine in Young Adults

  • Patricia Kaaijk,
  • Alienke J. Wijmenga-Monsuur,
  • Hinke I. ten Hulscher,
  • Jeroen Kerkhof,
  • Gaby Smits,
  • Mioara Alina Nicolaie,
  • Marianne A. van Houten and
  • Rob S. van Binnendijk

17 January 2022

Mumps outbreaks and breakthrough infections of measles and rubella have raised concerns about waning of vaccine-induced immunity after two doses of measles-mumps-rubella (MMR) vaccination. In the present follow-up study, serum IgG antibodies against...

  • Review
  • Open Access
18 Citations
5,673 Views
14 Pages

17 January 2022

Allergic diseases represent a global health and economic burden of increasing significance. The lack of disease-modifying therapies besides specific allergen immunotherapy (AIT) which is not available for all types of allergies, necessitates the stud...

  • Article
  • Open Access
11 Citations
3,114 Views
23 Pages

17 January 2022

Basketball is among the third most popular team sport in Italy. Albeit not usually perceived as being at high risk for tetanus, the Italian legal framework (Law No. 292 of 1963; Presidential Decree 1301/1965) requires tetanus vaccination (TeV) even f...

  • Article
  • Open Access
11 Citations
3,217 Views
14 Pages

Immune Enhancement by the Tetra-Peptide Hydrogel as a Promising Adjuvant for an H7N9 Vaccine against Highly Pathogenic H7N9 Virus

  • Xiaoxin Wu,
  • Songjia Tang,
  • Zhehua Wang,
  • Xiaoyun Ma,
  • Lingjian Zhang,
  • Fen Zhang,
  • Lanlan Xiao,
  • Shuai Zhao,
  • Qian Li and
  • Ying Wang
  • + 2 authors

17 January 2022

Background: Short peptide hydrogel was reported as a possible adjuvant for vaccines. In order to evaluate whether the Tetra-Peptide Hydrogel can be a promising adjuvant for an H7N9 vaccine against the highly pathogenic H7N9 virus, we conducted this s...

  • Article
  • Open Access
37 Citations
4,354 Views
13 Pages

COVID-19 Vaccine Hesitancy and Associated Factors among Diabetes Patients: A Cross-Sectional Survey in Changzhi, Shanxi, China

  • Ying Wang,
  • Lingrui Duan,
  • Mufan Li,
  • Jiayu Wang,
  • Jianzhou Yang,
  • Congying Song,
  • Jing Li,
  • Jinsheng Wang,
  • Jiantao Jia and
  • Junjie Xu

17 January 2022

Patients with diabetes are more susceptible to severe acute respiratory syndrome-associated coronavirus (SARS-CoV)-2 infection, but vaccine hesitancy is a problem in this population. We investigated the prevalence of SARS-CoV-2 vaccine hesitancy amon...

  • Article
  • Open Access
20 Citations
7,714 Views
17 Pages

Preclinical Evaluation of Chicken Egg Yolk Antibody (IgY) Anti-RBD Spike SARS-CoV-2—A Candidate for Passive Immunization against COVID-19

  • Hendris Wongso,
  • Isa Mahendra,
  • Wyanda Arnafia,
  • Idar Idar,
  • Muhammad Yusuf,
  • Arifudin Achmad,
  • Holis A. Holik,
  • Ahmad Kurniawan,
  • Iim Halimah and
  • Maula E. Sriyani
  • + 7 authors

17 January 2022

The coronavirus disease 2019 (COVID-19) has become a substantial threat to the international health sector and the global economy. As of 26 December 2021, the number of mortalities resulting from COVID-19 exceeded 5.3 million worldwide. The absence o...

  • Case Report
  • Open Access
8 Citations
19,447 Views
20 Pages

16 January 2022

For nearly a decade, case reports and series have emerged regarding dysautonomias—particularly postural orthostatic tachycardia syndrome (POTS)—presenting soon after vaccination against human papilloma virus (HPV). We too have observed a...

  • Case Report
  • Open Access
14 Citations
14,310 Views
8 Pages

Atypical Kawasaki Disease after COVID-19 Vaccination: A New Form of Adverse Event Following Immunization

  • Ana Lilia Peralta-Amaro,
  • Melina Ivone Tejada-Ruiz,
  • Karen Lilian Rivera-Alvarado,
  • Orestes de Jesús Cobos-Quevedo,
  • Patricia Romero-Hernández,
  • Wiliams Macías-Arroyo,
  • Alberto Avendaño-Ponce,
  • Jorge Hurtado-Díaz,
  • Olga Vera-Lastra and
  • Abihai Lucas-Hernández

16 January 2022

Kawasaki disease (KD) is a medium-vessel vasculitis that is typically presented during childhood; fewer than 100 cases of KD have been reported worldwide in adult patients who met the criteria according to the American College of Rheumatology. This s...

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Vaccines - ISSN 2076-393X