Table of Contents
Antioxidants, Volume 9, Issue 10 (October 2020) – 124 articles
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Cover Story (view full-size image) Cancer has become the second leading cause of death worldwide. Despite the advances of early [...] Read more. Cancer has become the second leading cause of death worldwide. Despite the advances of early diagnosis and anticancer therapies, cancer rates are expected to rise further. As such, cancer prevention continues to play an important role in cancer control. Among the hallmarks of cancer, maintenance of genomic integrity is crucial for cancer prevention and plays a role in mitigating the effects of oxidative stress. The nuclear factor erythroid 2-related factor 2 (Nrf2)/antioxidant response element (ARE) pathway is the key cell signaling mechanism that responds to oxidative stress to maintain redox homeostasis and thus counteract the deleterious effects of free radicals that can damage DNA. In this review paper, we discuss the role of dietary flavonoids on regulation of the Nrf2/ARE pathway in relation to cancer prevention and management. View this paper