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Antioxidants, Volume 11, Issue 9

September 2022 - 215 articles

Cover Story: Calcific aortic valve disease (CAVD) is an aging-related disease initiated by endothelial dysfunction. Integrin-linked kinase (ILK) is involved in preserving endothelial function; however, its role in CAVD is unknown. This study demonstrated that decreased ILK endothelial expression is strongly associated with human CAVD development. ILK exerts a protective role in CAVD by preventing the valvular endothelial dysfunction and osteogenic transformation initiated by endothelial cell phenotypic transition (endMT). Mechanistically, ILK decreases NO release and activates the TGF/Smad pathway, a critical inducer of endMT. Nitric oxide supplementation prevents VEC-osteogenic differentiation and TGF-β/Smad pathway activation. Thus, ILK may represent a new therapeutic target in CAVD. View this paper
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Articles (215)

  • Review
  • Open Access
60 Citations
10,903 Views
46 Pages

The Impact of Oxidative Stress and AKT Pathway on Cancer Cell Functions and Its Application to Natural Products

  • Jun-Ping Shiau,
  • Ya-Ting Chuang,
  • Jen-Yang Tang,
  • Kun-Han Yang,
  • Fang-Rong Chang,
  • Ming-Feng Hou,
  • Ching-Yu Yen and
  • Hsueh-Wei Chang

19 September 2022

Oxidative stress and AKT serine-threonine kinase (AKT) are responsible for regulating several cell functions of cancer cells. Several natural products modulate both oxidative stress and AKT for anticancer effects. However, the impact of natural produ...

  • Article
  • Open Access
30 Citations
3,880 Views
12 Pages

19 September 2022

This research investigated the effects of dietary rutin supplementation on the intestinal morphology, antioxidant capacity, immunity, and microbiota of aged laying hens. The results showed that 500 mg/kg rutin supplementation increased the villus hei...

  • Article
  • Open Access
38 Citations
11,355 Views
17 Pages

The Catechins Profile of Green Tea Extracts Affects the Antioxidant Activity and Degradation of Catechins in DHA-Rich Oil

  • Caroline Waingeh Nain,
  • Eric Mignolet,
  • Marie-France Herent,
  • Joëlle Quetin-Leclercq,
  • Cathy Debier,
  • Melissa M. Page and
  • Yvan Larondelle

19 September 2022

This study investigated the effect of the catechins profile on the antioxidant activity of green tea extracts (GTEs) by comparing the antioxidant activity of an EGC-rich GTE (GTE1, catechin content: 58% EGC, 30.1% EGCG, 7.9% EC, and 3.9% ECG) and an...

  • Article
  • Open Access
21 Citations
4,771 Views
20 Pages

Carob (Ceratonia siliqua) as Functional Feed Is Beneficial in Yellow Mealworm (Tenebrio molitor) Rearing: Evidence from Growth, Antioxidant Status and Cellular Responses

  • Efthimia Antonopoulou,
  • Nikolas Panteli,
  • Kostantinos Feidantsis,
  • Maria Mastoraki,
  • Eleni I. Koutsogeorgiou,
  • Eirini Grivaki,
  • Theodora Papagrigoriou,
  • Spyros P. Christias,
  • Stavros Chatzifotis and
  • Diamanto Lazari
  • + 2 authors

19 September 2022

In terms of sustainability and circular economy, agricultural by-products may be efficiently reused in insects’ rearing for high-quality protein sources in human diet and animal feeds. The present study aimed to explore whether the utilization of car...

  • Review
  • Open Access
26 Citations
4,885 Views
19 Pages

The Current State of Knowledge in Biological Properties of Cirsimaritin

  • Taoufiq Benali,
  • Imane Jaouadi,
  • Rokia Ghchime,
  • Nasreddine El Omari,
  • Kaoutar Harboul,
  • Khalil Hammani,
  • Maksim Rebezov,
  • Mohammad Ali Shariati,
  • Mohammad S. Mubarak and
  • Jesus Simal-Gandara
  • + 6 authors

19 September 2022

The search for natural plant-based products as new pharmacological alternatives to treat various human pathologies has taken on great importance for researchers and research laboratories. In this context, research has intensified to extract and ident...

  • Article
  • Open Access
6 Citations
3,943 Views
13 Pages

The Aftermath of Long-Term Cigarette Smoking on Telomere Length and Mitochondrial DNA Copy Number in Human Cumulus Cells Prior to In Vitro Fertilization—A Pilot Study

  • Fani Konstantinidou,
  • Maria Cristina Budani,
  • Guya Diletta Marconi,
  • Francesca Gonnella,
  • Annalina Sarra,
  • Oriana Trubiani,
  • Liborio Stuppia,
  • Gian Mario Tiboni and
  • Valentina Gatta

19 September 2022

Cigarette smoking among women of reproductive age is known to take a toll on systemic health and fertility potential by severely impacting ovarian tissues and cells, such as granulosa and cumulus cells (CCs). The purpose of this study was to determin...

  • Article
  • Open Access
24 Citations
4,618 Views
15 Pages

Eugenol Attenuates Transmissible Gastroenteritis Virus-Induced Oxidative Stress and Apoptosis Via ROS-NRF2-ARE Signaling

  • Kang Wang,
  • Yan Tang,
  • Xiu Wu,
  • Hongmin Liang,
  • Daiwen Chen,
  • Bing Yu,
  • Jun He,
  • Xiangbing Mao,
  • Zhiqing Huang and
  • Hui Yan
  • + 6 authors

18 September 2022

Transmissible gastroenteritis virus (TGEV), a coronavirus that causes severe diarrhea due to oxidative stress in the piglet intestine, is a major cause of economic loss in the livestock industry. However, limited interventions have been shown to be e...

  • Article
  • Open Access
13 Citations
3,895 Views
13 Pages

PD-1 Alleviates Cisplatin-Induced Muscle Atrophy by Regulating Inflammation and Oxidative Stress

  • Xiaoguang Liu,
  • Miaomiao Xu,
  • Yang Yu,
  • Yingjie Chen,
  • Xinyu Weng and
  • Lin Zhu

18 September 2022

Skeletal muscle atrophy is an important characteristic of cachexia, which can be induced by chemotherapy and significantly contributes to functional muscle impairment. Inflammation and oxidative stress are believed to play important roles in the musc...

  • Article
  • Open Access
11 Citations
3,461 Views
17 Pages

18 September 2022

Chelerythrine (CHE) is a majorly harmful isoquinoline alkaloid ingredient in Chelidonium majus that could trigger potential hepatotoxicity, but the pivotal molecular mechanisms remain largely unknown. In the present study, CHE-induced cytotoxicity an...

  • Article
  • Open Access
6 Citations
6,952 Views
12 Pages

Natural Activators of Autophagy Increase Maximal Walking Distance and Reduce Oxidative Stress in Patients with Peripheral Artery Disease: A Pilot Study

  • Ombretta Martinelli,
  • Mariangela Peruzzi,
  • Simona Bartimoccia,
  • Alessandra D’Amico,
  • Simona Marchitti,
  • Speranza Rubattu,
  • Giovanni Alfonso Chiariello,
  • Luca D’Ambrosio,
  • Sonia Schiavon and
  • Fabio Miraldi
  • + 7 authors

18 September 2022

Trehalose, spermidine, nicotinamide, and polyphenols have been shown to display pro-autophagic and antioxidant properties, eventually reducing cardiovascular and ischemic complications. This study aimed to investigate whether a mixture of these compo...

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Antioxidants - ISSN 2076-3921