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Antioxidants
Volume 11
Issue 9
10.3390/antiox11091845
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Review

The Impact of Oxidative Stress and AKT Pathway on Cancer Cell Functions and Its Application to Natural Products

by
Jun-Ping Shiau
1,†,
Ya-Ting Chuang
2,†,
Jen-Yang Tang
3,4,
Kun-Han Yang
5,
Fang-Rong Chang
5,
Ming-Feng Hou
1,6,
Ching-Yu Yen
7,8,* and
Hsueh-Wei Chang
6,9,*
1
Division of Breast Oncology and Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
2
Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
3
School of Post-Baccalaureate Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
4
Department of Radiation Oncology, Kaohsiung Medical University Hospital, Kaoshiung Medical University, Kaohsiung 80708, Taiwan
5
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
6
Department of Biomedical Science and Environmental Biology, College of Life Science, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
7
Department of Oral and Maxillofacial Surgery, Chi-Mei Medical Center, Tainan 71004, Taiwan
8
School of Dentistry, Taipei Medical University, Taipei 11031, Taiwan
9
Center for Cancer Research, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Antioxidants 2022, 11(9), 1845; https://doi.org/10.3390/antiox11091845
Submission received: 29 August 2022 / Revised: 14 September 2022 / Accepted: 16 September 2022 / Published: 19 September 2022
(This article belongs to the Special Issue Natural Products as Agents of Targeted Cancer Therapeutic Action)
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Abstract

Oxidative stress and AKT serine-threonine kinase (AKT) are responsible for regulating several cell functions of cancer cells. Several natural products modulate both oxidative stress and AKT for anticancer effects. However, the impact of natural product-modulating oxidative stress and AKT on cell functions lacks systemic understanding. Notably, the contribution of regulating cell functions by AKT downstream effectors is not yet well integrated. This review explores the role of oxidative stress and AKT pathway (AKT/AKT effectors) on ten cell functions, including apoptosis, autophagy, endoplasmic reticulum stress, mitochondrial morphogenesis, ferroptosis, necroptosis, DNA damage response, senescence, migration, and cell-cycle progression. The impact of oxidative stress and AKT are connected to these cell functions through cell function mediators. Moreover, the AKT effectors related to cell functions are integrated. Based on this rationale, natural products with the modulating abilities for oxidative stress and AKT pathway exhibit the potential to regulate these cell functions, but some were rarely reported, particularly for AKT effectors. This review sheds light on understanding the roles of oxidative stress and AKT pathway in regulating cell functions, providing future directions for natural products in cancer treatment.
Keywords: AKT signaling; oxidative stress; natural product; cell function AKT signaling; oxidative stress; natural product; cell function

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MDPI and ACS Style

Shiau, J.-P.; Chuang, Y.-T.; Tang, J.-Y.; Yang, K.-H.; Chang, F.-R.; Hou, M.-F.; Yen, C.-Y.; Chang, H.-W. The Impact of Oxidative Stress and AKT Pathway on Cancer Cell Functions and Its Application to Natural Products. Antioxidants 2022, 11, 1845. https://doi.org/10.3390/antiox11091845

AMA Style

Shiau J-P, Chuang Y-T, Tang J-Y, Yang K-H, Chang F-R, Hou M-F, Yen C-Y, Chang H-W. The Impact of Oxidative Stress and AKT Pathway on Cancer Cell Functions and Its Application to Natural Products. Antioxidants. 2022; 11(9):1845. https://doi.org/10.3390/antiox11091845

Chicago/Turabian Style

Shiau, Jun-Ping, Ya-Ting Chuang, Jen-Yang Tang, Kun-Han Yang, Fang-Rong Chang, Ming-Feng Hou, Ching-Yu Yen, and Hsueh-Wei Chang. 2022. "The Impact of Oxidative Stress and AKT Pathway on Cancer Cell Functions and Its Application to Natural Products" Antioxidants 11, no. 9: 1845. https://doi.org/10.3390/antiox11091845

APA Style

Shiau, J.-P., Chuang, Y.-T., Tang, J.-Y., Yang, K.-H., Chang, F.-R., Hou, M.-F., Yen, C.-Y., & Chang, H.-W. (2022). The Impact of Oxidative Stress and AKT Pathway on Cancer Cell Functions and Its Application to Natural Products. Antioxidants, 11(9), 1845. https://doi.org/10.3390/antiox11091845

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