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Brain Sciences, Volume 9, Issue 8

August 2019 - 35 articles

Cover Story: Alzheimer's disease is a neurological disorder characterized by brain cell death, memory loss and cognitive decline. The porpouse of this work was to study the transcriptional profile in cells of neuroblastoma differentiated with retinoic acid, exposed to Aβ1-42 and subsequently treated with α-tocopherol. The results of the transcriptomic analysis showed that the treatment of α-tocopherol upregulated the genes involved in processing the APP through the non-amyloidogenic pathway. Furthermore, α-tocopherol modulated the expression of genes involved in autophagy by degrading the autophagosomes. In addition, α-tocopherol downregulated some cell cycle markers, such as cyclins and cyclin-dependent kinases and markers of DNA replication. Immunohistochemistry has shown that treatment with α-tocopherol was also able to reduce oxidative stress. View this paper.
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Articles (35)

  • Review
  • Open Access
22 Citations
9,268 Views
12 Pages

Long-Term Cognitive Performance of Retired Athletes with Sport-Related Concussion: A Systematic Review and Meta-Analysis

  • Yanjie Zhang,
  • Yongzhi Ma,
  • Shihui Chen,
  • Xiaolei Liu,
  • Hye Jung Kang,
  • Siera Nelson and
  • Samantha Bell

13 August 2019

Objective: The purpose of this systematic review is to quantitatively estimate (or invest) the impacts of sports-related concussions (SRCs) on cognitive performance among retired athletes more than 10 years after retirement. Methods: Six databases in...

  • Article
  • Open Access
26 Citations
7,803 Views
12 Pages

12 August 2019

A significant challenge for fMRI research is statistically controlling for false positives without omitting true effects. Although a number of traditional methods for multiple comparison correction exist, several alternative tools have been developed...

  • Article
  • Open Access
28 Citations
4,888 Views
16 Pages

α-Tocopherol Modulates Non-Amyloidogenic Pathway and Autophagy in an In Vitro Model of Alzheimer’s Disease: A Transcriptional Study

  • Agnese Gugliandolo,
  • Luigi Chiricosta,
  • Serena Silvestro,
  • Placido Bramanti and
  • Emanuela Mazzon

10 August 2019

Alzheimer’s disease (AD) is the most common form of dementia worldwide. The hallmarks of AD are the extracellular amyloid plaques, which are formed by amyloid β (Aβ) aggregates derived from the processing of the amyloid precursor prot...

  • Article
  • Open Access
16 Citations
5,831 Views
12 Pages

Manual Therapy Reduces Pain Behavior and Oxidative Stress in a Murine Model of Complex Regional Pain Syndrome Type I

  • Afonso S. I. Salgado,
  • Juliana Stramosk,
  • Daniela D. Ludtke,
  • Ana C. C. Kuci,
  • Daiana C. Salm,
  • Lisandro A. Ceci,
  • Fabricia Petronilho,
  • Drielly Florentino,
  • Lucineia G. Danielski and
  • Aline Gassenferth
  • + 6 authors

10 August 2019

Complex regional pain syndrome type I (CRPS-I) is a chronic painful condition. We investigated whether manual therapy (MT), in a chronic post-ischemia pain (CPIP) model, is capable of reducing pain behavior and oxidative stress. Male Swiss mice were...

  • Article
  • Open Access
17 Citations
4,505 Views
11 Pages

Improved Central Nervous System Symptoms in People with HIV without Objective Neuropsychiatric Complaints Switching from Efavirenz to Rilpivirine Containing cART

  • Jaime H. Vera,
  • Margherita Bracchi,
  • Jasmini Alagaratnam,
  • Julianne Lwanga,
  • Julie Fox,
  • Alan Winston,
  • Marta Boffito and
  • Mark Nelson

Objective: Occult central nervous system (CNS) symptoms not recognized by people living with HIV (PLWH) receiving efavirenz or their clinicians could occur and impact people’s quality of life. The aim of this study was to determine whether CNS...

  • Article
  • Open Access
12 Citations
5,744 Views
28 Pages

Under the Implicit Prosody Hypothesis, readers generate prosodic structures during silent reading that can direct their real-time interpretations of the text. In the current study, we investigated the processing of implicit meter by recording event-r...

  • Perspective
  • Open Access
11 Citations
7,221 Views
14 Pages

Age-related brain white matter disease is a form of small vessel disease (SVD) that may be associated with lacunar and other small subcortical infarcts, cerebral microbleeds, and perivascular spaces. This common form of cerebrovascular disease may ma...

  • Perspective
  • Open Access
34 Citations
6,355 Views
14 Pages

Neuroimaging in Pediatric Epilepsy

  • Zakir Shaikh,
  • Alcy Torres and
  • Masanori Takeoka

Pediatric epilepsy presents with various diagnostic challenges. Recent advances in neuroimaging play an important role in the diagnosis, management and in guiding the treatment of pediatric epilepsy. Structural neuroimaging techniques such as CT and...

  • Review
  • Open Access
63 Citations
6,472 Views
16 Pages

Gambling Problems and Alexithymia: A Systematic Review

  • Daniela Marchetti,
  • Maria Cristina Verrocchio and
  • Piero Porcelli

Among the factors that are thought to underlie gambling problems, alexithymia has been recognized to contribute to their development. For the first time, we reviewed the literature on the relationship between alexithymia and gambling. A systematic se...

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Brain Sci. - ISSN 2076-3425