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Association between Interictal Epileptiform Discharges and Autistic Spectrum Disorder

Laboratorio de Medicina de Conservación y Maestría en Ciencias de la Salud, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón S/N, Col. Casco de Santo Tomás, Alcaldía Miguel Hidalgo CP 11340, Mexico
Departamento de Higiene Mental, Hospital General Centro Médico Nacional “La Raza”, Instituto Mexicano del Seguro Social, Distrito Federal CP 02990, Mexico
Authors to whom correspondence should be addressed.
Brain Sci. 2019, 9(8), 185;
Received: 27 June 2019 / Revised: 28 July 2019 / Accepted: 30 July 2019 / Published: 30 July 2019
(This article belongs to the Special Issue Disrupted Functional Connectivity in Autism Spectrum Disorder)
PDF [307 KB, uploaded 2 August 2019]


It has been reported that bioelectric alterations in an electroencephalogram (EEG) may play an etiological role in neurodevelopmental disorders. The clinical impact of interictal epileptiform discharges (IEDs) in association with autistic spectrum disorder (ASD) is unknown. The Autism Diagnostic Interview-Revised (ADI-R) is one of the gold standards for the diagnosis of autistic spectrum disorder. Some studies have indicated high comorbidity of IED and ASD, while other studies have not supported an association between the central symptoms of autism and IED. This review examines the high comorbidity and clinical impact of IED; patients with epilepsy are excluded from the scope of this review. ASD can be disabling and is diagnosed at an average age of 5 years old, at which point the greatest neurological development has occurred. If an association between IED and ASD is identified, a clinical tool that entails an innocuous procedure could enable diagnosis in the first years of life. However, in the absence of reports that prove an association between IED and ASD, patients should not be subjected to expensive treatments, such as the administration of anticonvulsant therapies. View Full-Text
Keywords: autistic spectrum disorder; EEG; interictal epileptiforme discharges; ADI-R autistic spectrum disorder; EEG; interictal epileptiforme discharges; ADI-R
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Luz-Escamilla, L.; Morales-González, J.A. Association between Interictal Epileptiform Discharges and Autistic Spectrum Disorder. Brain Sci. 2019, 9, 185.

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