Table of Contents
Brain Sci., Volume 9, Issue 7 (July 2019)
- Issues are regarded as officially published after their release is announced to the table of contents alert mailing list.
- You may sign up for e-mail alerts to receive table of contents of newly released issues.
- PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.
Cover Story (view full-size image) Immune dysfunction is often reported in autism spectrum disorders (ASD), however, the extent and [...] Read more. Immune dysfunction is often reported in autism spectrum disorders (ASD), however, the extent and type of inflammation has been reported with mixed and sometimes contradictory findings. One common component that may help to explain these different inflammatory profiles is deficits in immune regulation. We and others have previously found reductions in regulatory T cells (Tregs) and associated cytokines. Tregs, though they make up a small percentage of the body’s lymphocytes, provide the necessary signals required to control immune responses and bring the immune system back to homeostasis. In the current study we describe reduced plasma interluekin-35, a novel immunoregulatory cytokine produced primarily by Tregs, in children with ASD and discuss how deficits in immune regulation may contribute to etiology and aberrant behaviors associated with ASD. View this paper