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Article

Genetic Relationships Between Ethanol-Induced Conditioned Place Aversion and Other Ethanol Phenotypes in 15 Inbred Mouse Strains

Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health & Science University, Portland, OR 97239, USA
Brain Sci. 2019, 9(8), 209; https://doi.org/10.3390/brainsci9080209
Received: 14 July 2019 / Revised: 16 August 2019 / Accepted: 17 August 2019 / Published: 20 August 2019
The genetic relationships between different behaviors used to index the aversive effects of ethanol are unknown. To address this issue, ethanol-induced conditioned place aversion (CPA) was tested in a genetically diverse panel of 15 inbred mouse strains. Mice were exposed to an unbiased place conditioning procedure using ethanol doses of 0, 2, or 4 g/kg; all injections were given immediately after 5-min exposure to distinctive tactile cues. There were dose-dependent effects of ethanol on CPA and on the change in pre-injection activity rates between the first and last conditioning trials. Most strains (80%) developed CPA, demonstrating the generalizability of this behavior. Moreover, genotype had significant effects on CPA magnitude and locomotor activity rates. Strain means from this study and previously published studies were then used to examine genetic correlations. These analyses showed significant genetic correlations between CPA and ethanol intake/preference, conditioned taste aversion, and drug withdrawal (but not blood ethanol concentration or conditioned place preference), supporting the idea of commonality in the genes underlying CPA and each of these behaviors. The overall pattern of findings is consistent with previous data suggesting that genetic differences in sensitivity to ethanol’s aversive effects play a role in determining strain differences in ethanol drinking. The broader implication is that individuals who are more sensitive to the aversive effects of ethanol may be protected from developing the excessive drinking behaviors characteristic of alcohol use disorders. View Full-Text
Keywords: alcohol; reinforcement; reward; place aversion; taste aversion; drinking; withdrawal; locomotor activity; learning; inbred strains alcohol; reinforcement; reward; place aversion; taste aversion; drinking; withdrawal; locomotor activity; learning; inbred strains
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MDPI and ACS Style

Cunningham, C.L. Genetic Relationships Between Ethanol-Induced Conditioned Place Aversion and Other Ethanol Phenotypes in 15 Inbred Mouse Strains. Brain Sci. 2019, 9, 209. https://doi.org/10.3390/brainsci9080209

AMA Style

Cunningham CL. Genetic Relationships Between Ethanol-Induced Conditioned Place Aversion and Other Ethanol Phenotypes in 15 Inbred Mouse Strains. Brain Sciences. 2019; 9(8):209. https://doi.org/10.3390/brainsci9080209

Chicago/Turabian Style

Cunningham, Christopher L. 2019. "Genetic Relationships Between Ethanol-Induced Conditioned Place Aversion and Other Ethanol Phenotypes in 15 Inbred Mouse Strains" Brain Sciences 9, no. 8: 209. https://doi.org/10.3390/brainsci9080209

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