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Brain Sciences, Volume 16, Issue 6

2026 June - 113 articles

Cover Story: A structured literature search was performed in PubMed, Scopus, and Web of Science, focusing on scientific output addressing adult and pediatric chronic pain, pain-related neuroplasticity, functional network alterations, neuromodulation, and AI-based applications in pain medicine. Results: The reviewed literature supports a progressive conceptual shift from region-based representations of pain toward network-oriented models involving dysfunctional interactions among the salience, default mode, central executive, and sensorimotor networks. Although emerging evidence suggests developmental network alterations in pediatric chronic pain, current conclusions remain limited by the relative scarcity of longitudinal neuroimaging studies. Emerging AI applications show promising potential for objective pain assessment, trajectory prediction, and personalized therapeutic decision-making. View this paper
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Articles (113)

  • Article
  • Open Access
676 Views
14 Pages

Anterior Cingulate Cortex Mediates State-Dependent Prioritization of Distressed Conspecifics

  • Hongyu Cao,
  • Yang Zhou,
  • Saifeng Zhao,
  • Chenyi Guo,
  • Xiao-Dan Yu,
  • Wenhui Xiao,
  • Ge Hu,
  • Lianyan Huang,
  • Boxing Li and
  • Xiao Min Zhang

Background/Objectives: Emotion recognition is a fundamental component of mammalian social cognition, enabling animals such as rodents to detect the emotional states of conspecifics and guide prosocial or avoidance behaviors. However, natural social l...

(This article belongs to the Section Behavioral Neuroscience)
  • Article
  • Open Access
570 Views
12 Pages

Hemispherotomy for Pediatric Post-Traumatic Epilepsy

  • Habib E. Akouri,
  • Samuel B. Tomlinson,
  • Kevin Wojcik,
  • Nankee K. Kumar,
  • Kathleen Galligan,
  • Sudha K. Kessler and
  • Benjamin C. Kennedy

Objective: Hemispherotomy is an effective treatment for select forms of drug-resistant hemispheric epilepsy, including perinatal stroke, Rasmussen’s encephalitis, and Sturge–Weber syndrome. Post-traumatic epilepsy (PTE) has been reported...

(This article belongs to the Section Neurosurgery and Neuroanatomy)
  • Editorial
  • Open Access
416 Views
5 Pages

When Robots Learn: Artificial Intelligence and the Next Human-Centered Era of Neurorehabilitation

  • Rocco Salvatore Calabrò,
  • David Perpetuini and
  • Irene Giovanna Aprile

Neurological disorders remain among the leading causes of long-term disability, care dependency and loss of healthy life worldwide [...]

(This article belongs to the Special Issue The Use of Robotics and Artificial Intelligence in Neurorehabilitation: From Diagnosis to Treatment)
  • Article
  • Open Access
588 Views
22 Pages

Background: Mild Cognitive Impairment (MCI) is a clinical state between normal aging and dementia. It may involve impairment in one or several cognitive domains. MCI offers a key window for maintaining cognitive function and studying how deficits dev...

(This article belongs to the Section Cognitive, Social and Affective Neuroscience)
  • Article
  • Open Access
535 Views
14 Pages

Beyond Ventricular Enlargement: Multimodal MRI Assessment Improves Surgical Decision-Making in Normal Pressure Hydrocephalus

  • Duygu Baykal,
  • Mustafa Umut Etli,
  • Muhammed Enes Atik,
  • Zekeriya Gedikli,
  • Mehmet Ziya Çetiner,
  • Ahmet Kürşat Kara and
  • Semra Işık

Objectives: This study aimed to evaluate the utility of MRI-based morphometric and qualitative parameters in identifying patients with suspected normal pressure hydrocephalus (NPH) associated with shunt surgery selection following clinical and lumbar...

(This article belongs to the Section Neurosurgery and Neuroanatomy)
  • Article
  • Open Access
846 Views
22 Pages

Background/Objectives: Verb anomia is a common symptom of primary progressive aphasia (PPA), particularly in the logopenic variant (lvPPA). Despite the central role of verbs in sentence construction, interventions specifically targeting verb anomia r...

(This article belongs to the Special Issue Primary Progressive Aphasia: What Happens to Speech and Language? What Can We Do to Help?)
  • Article
  • Open Access
1 Citations
567 Views
17 Pages

Background/Objectives. Automated lateral ventricle volumetry is increasingly used in population-based neuroimaging, but correlation between methods does not establish agreement of absolute volumes. We quantified agreement and calibration between Free...

  • Systematic Review
  • Open Access
3 Citations
2,350 Views
42 Pages

Background/Objectives: Emotion processing has increasingly been conceptualized as a transdiagnostic mechanism underlying psychological adaptation and psychopathology. From an attachment perspective, individual differences in emotion perception may be...

(This article belongs to the Topic The Relationship Between Bodily, Autonomic, and Communicative Behaviors and the Experiential and Cognitive Aspects of Emotion)
  • Review
  • Open Access
746 Views
14 Pages

Obesity is one of the most serious public health challenges worldwide and has reached the scale of a global epidemic. Its etiology is multifactorial and includes genetic, environmental, hormonal, and neurobiological factors. In recent years, increasi...

(This article belongs to the Section Neuropsychiatry)
  • Article
  • Open Access
1 Citations
535 Views
42 Pages

Background/Objectives: Advancements in neuroscience and machine learning have increasingly enabled brain pattern recognition based on bio-signal measurements, such as electroencephalography (EEG). These developments support next-generation technologi...

(This article belongs to the Section Cognitive, Social and Affective Neuroscience)
  • Article
  • Open Access
588 Views
16 Pages

Is High Fat and Sugar Intake Associated with Disrupted Attentional–Motivational Coupling for Food? Evidence from an Eye Tracking Study

  • Tuki Attuquayefio,
  • Olivia Lauren Aguiar,
  • Bandal Boutros,
  • Peter Jacquier,
  • Richard J. Stevenson and
  • Gesualdo M. Zucco

Background: Frequent consumption of foods high in fat and sugar (HFS) has been linked to disrupted appetite regulation (via hippocampal dysfunction) and an increased tendency to continue desiring palatable foods, even when physiologically full. While...

(This article belongs to the Section Systems Neuroscience)
  • Article
  • Open Access
660 Views
20 Pages

Background: Acute carbon monoxide (CO) poisoning can cause delayed neuropsychiatric sequelae (DNS) after a latent period, yet its pathophysiology remains poorly understood because of the lack of reproducible experimental models. Methods: We establish...

(This article belongs to the Special Issue Advances in Dopamine and Cognition)
  • Systematic Review
  • Open Access
1,526 Views
12 Pages

Attention Deficit/Hyperactivity Disorder and Risk of Dementia: A Systematic Review and Meta-Analysis

  • Ludovico Baiamonte,
  • Giovanna Bellante,
  • Patrizio Allegra,
  • Domenico Tarantino,
  • Claudia Migliazzo,
  • Manuela Lodico,
  • Laura Maniscalco,
  • Tommaso Piccoli,
  • Nicola Vanacore and
  • Giuseppe Salemi
  • + 1 author

Introduction: The significant impact of attention deficit/hyperactivity disorder (ADHD) on health in adult life has been widely recognized. Among the comorbidities of this disorder in later life, dementia is one of the most relevant ones. We performe...

(This article belongs to the Section Neurodegenerative Diseases)
  • Article
  • Open Access
563 Views
28 Pages

Aperiodic Dynamics of Cell Assemblies Recruited for L1 and L2 Processing of French Wh-Dependencies Highlight a Temporo-Parietal Engagement in Syntax

  • Laurent Dekydtspotter,
  • A. Kate Miller,
  • Mike Iverson,
  • Jih-Ho Cha,
  • Ludan Yang,
  • Jane A. Gilbert,
  • Hongyu Zhang,
  • Kent Meinert,
  • Qin Li and
  • Jae Hyun Ahn

Background/Objectives: A current debate addresses where syntactic Merge primarily resides: the left-hemisphere posterior inferior frontal gyrus (IFG) or the temporo-parietal cortex. For proponents of the former, the temporo-parietal cortex supports m...

(This article belongs to the Special Issue Memory and Cognition in Bi/Multilingual Minds: Mechanisms, Models, and Developmental Pathways)
  • Article
  • Open Access
686 Views
15 Pages

Personalized Music-Embedded Sound Therapy Based on Gating Modulation and Neural Decoupling Reduces Tinnitus Severity

  • Pablo I. Henriquez,
  • Paul H. Delano,
  • Javiera Herrada,
  • Claudia Guevara and
  • Hayo A. Breinbauer

Background: Tinnitus is a prevalent auditory disorder associated with maladaptive cortical plasticity and aberrant neural synchronization across auditory and non-auditory brain networks. Acoustic desynchronization-based sound therapies, such as coord...

(This article belongs to the Section Cognitive, Social and Affective Neuroscience)
  • Article
  • Open Access
843 Views
14 Pages

Longitudinal Transcriptomic Analysis Reveals Systemic Effects of Risdiplam in Adults with Spinal Muscular Atrophy

  • Maria Liguori,
  • Arianna Consiglio,
  • Eustachio D’Errico,
  • Ylenia Antonacci,
  • Martina Coffa,
  • Alessandro Introna and
  • Isabella Laura Simone

Background: Spinal Muscular Atrophy (SMA) is a neurodegenerative disease caused by reduced survival motor neuron (SMN) protein levels due to SMN1 gene mutations. The natural history of SMA has dramatically changed since innovative therapies were appr...

(This article belongs to the Special Issue Molecular and Cellular Research in Neurodegenerative Diseases)
  • Article
  • Open Access
1 Citations
737 Views
24 Pages

Age-Related Differences in Neural Networks for Error Detection and Inhibitory Control: A LORETA-Based Comparative Study

  • Kazumasa Ukai,
  • Kazuhei Nishimoto,
  • Hiroki Ito,
  • Kouta Maeda,
  • Ryosuke Yamauchi,
  • Osamu Katayama,
  • Shin Murata,
  • Kiichiro Morita and
  • Takayuki Kodama

Background/Objectives: Assessing inhibitory function and error detection is crucial for the early detection of age-related cognitive decline. This study aimed to investigate the neural network dynamics underlying these functions in younger and older...

(This article belongs to the Section Computational Neuroscience, Neuroinformatics, and Neurocomputing)
  • Review
  • Open Access
413 Views
16 Pages

Visual working memory (VWM) declines with age and has been explained by multiple mechanisms, including reduced precision, capacity limitations, binding deficits, and altered attentional control. However, these accounts are typically framed within a u...

(This article belongs to the Special Issue Ageing and Visual Working Memory: Cognitive and Neural Perspectives)
  • Editorial
  • Open Access
830 Views
5 Pages

Hearing impairment is among the most prevalent sensory disorders worldwide, affecting far more than just auditory thresholds [...]

(This article belongs to the Special Issue Recent Advances in Hearing Impairment)
  • Review
  • Open Access
1,293 Views
20 Pages

From the Pain Matrix to Functional Networks: A Narrative Review of Chronic Pain Mechanisms Across Adult and Pediatric Populations with Emerging AI Perspectives

  • Marco Cascella,
  • Daniela Siano,
  • Mauro D’Amora,
  • Corrado Cecchetti,
  • Alessandro Vittori,
  • Maria Romano and
  • Vittorio Santoriello

Background: While region-based models have informed pain neuroscience, chronic pain is now increasingly conceptualized as a network disorder. This narrative review aimed to critically examine the conceptual evolution of chronic pain models from regio...

(This article belongs to the Special Issue Biobehavioral Neuroscience and Pain Medicine: Assessment and Management of Pain)
  • Article
  • Open Access
615 Views
10 Pages

Synaptic Inputs to OFF Parasol Ganglion Cells in Macaque Retina: An Analysis Using Serial Blockface Scanning Electron Microscopy

  • David W. Marshak,
  • Andrea S. Bordt,
  • Nicole B. Harris,
  • James A. Kuchenbecker,
  • Judith Mosinger Ogilvie,
  • Sara S. Patterson and
  • Jay Neitz

Background/Objectives: Ganglion cells are the projection neurons of the retina, and there are multiple types that differ in their morphology, light responses and central projections. Parasol cells are one of the major retinal ganglion cell types in p...

(This article belongs to the Special Issue The Eye as the Window to Brain Science: Fields of Neuroscience Created from Eye Research)
  • Article
  • Open Access
843 Views
11 Pages

Pervasive TBI and Inhibitory Control in a Male New Zealand Prison Population

  • Sam Guy,
  • Susan Mahon,
  • James Webb,
  • Makarena Dudley and
  • Alice Theadom

Objective: Traumatic brain injury (TBI) is disproportionately prevalent in incarcerated populations, yet the potential impact on cognitive functioning remains underexplored. This study examined the relationship between TBI history and cognitive perfo...

(This article belongs to the Special Issue Accessing Treatment and Rehabilitation for Underserved Survivors of Brain Injury)
  • Article
  • Open Access
574 Views
16 Pages

Stability in Reading Improvement After Home-Based Multi-Componential Training for Children with Developmental Dyslexia

  • Elena Capelli,
  • Sara Mascheretti,
  • Enrica Rosso,
  • Patrizia Bernasconi,
  • Renato Borgatti,
  • Serena Lecce,
  • Alessandra Piccolini,
  • Simonetta Cardinali,
  • Cristiano Termine and
  • Laura Farinotti

Background: RIDInet-Reading Trainer 2 (RT-2) is a web-platform for the remote treatment of developmental dyslexia (DD) which has been shown to improve reading performance. However, no previous studies have investigated stability in reading improvemen...

(This article belongs to the Special Issue Beyond Boundaries: Current Advances in Developmental Learning Disorders)
  • Article
  • Open Access
562 Views
18 Pages

Voluntary Wheel Running as Refinement Tool for Postoperative Severity Assessment and Humane Endpoint Detection in Rats with Brain Tumors

  • Alina L. Ottlewski,
  • Christine Häger,
  • Elvis J. Hermann,
  • Franck Fogaing Kamgaing,
  • Mesbah Alam,
  • Jannik D. Schwabe,
  • Hauke Thiesler,
  • Herbert Hildebrandt,
  • Aylina Glasenapp and
  • Kerstin Schwabe
  • + 3 authors

Background: In rodent models of intracranial tumor development, evaluating the actual burden experienced by animals beyond procedural severity is essential for ethical and legal compliance. This study examined whether voluntary wheel running (VWR) co...

(This article belongs to the Section Behavioral Neuroscience)
  • Systematic Review
  • Open Access
1,495 Views
15 Pages

Emerging Role of BTK Inhibitors in Multiple Sclerosis: From Immunobiology to Clinical Translation

  • Aashray Raj,
  • Vansh Patel,
  • Mehak Dang,
  • Aken Kayastha,
  • Yusuf Kagzi,
  • Praveen Nandha Kumar Pitchan Velammal,
  • Nidhi Agrawal,
  • Kushagra Sharma,
  • Nicholas Hansen and
  • Shitiz Sriwastava
  • + 2 authors

Background: Multiple sclerosis (MS), an autoimmune disease, involves peripheral immune activation followed by CNS inflammation in a compartmentalized manner. Although high-efficacy disease-modifying therapies (HE-DMTs) have been effective in suppress...

(This article belongs to the Special Issue Hot Topics in Multiple Sclerosis and Related Autoimmune Disorders)
  • Article
  • Open Access
1,168 Views
18 Pages

Effects of LEGO®-Based Neurotherapy on Executive Functions in Children with Autism Spectrum Disorder: A Quasi-Experimental Study

  • Noemí Cárdenas-Rodríguez,
  • Julieta Griselda Mendoza-Torreblanca,
  • Norma Angélica Labra-Ruiz,
  • Lizbeth Naranjo-Albarrán,
  • Daniel B. LeGoff and
  • Eduardo Espinosa-Garamendi

Background: Children with autism spectrum disorder (ASD) commonly exhibit impairments in executive functioning, which can affect their cognitive and adaptive functioning. Play-based neurohabilitation approaches have been proposed as complementary str...

(This article belongs to the Special Issue Neurocognitive Interventions for Cognitive Disorders: From Mechanisms to Treatment)
  • Review
  • Open Access
1 Citations
1,896 Views
27 Pages

Major depressive disorder (MDD) is a complex and heterogeneous psychiatric disorder with a high prevalence. Neuroinflammation may define biologically distinct patient subgroups with different mechanisms, clinical phenotypes, and treatment responses....

(This article belongs to the Special Issue Advances in Emotion Processing and Cognitive Neuropsychology)
  • Article
  • Open Access
561 Views
18 Pages

Safety, Feasibility, and Exploratory Functional Changes During GRILLO© Gait Trainer Use in Adults with Severe Acquired Brain Injury: A Retrospective Observational Study

  • Donatella Saviola,
  • Stefania Bruni,
  • Andrea Rattotti,
  • Raffaella Benoldi,
  • Katia Cristella,
  • Elisa Quintavalla,
  • Monica Pizzaferri and
  • Antonio De Tanti

Background/Objectives: Assisted verticalization and supported upright activity are relevant components of rehabilitation in adults with severe acquired brain injury (sABI), although patient selection and implementation remain challenging. This retros...

(This article belongs to the Special Issue Advances in Rehabilitation Strategies for Traumatic Brain Injury)
  • Article
  • Open Access
1,064 Views
17 Pages

Role of Institutionalization in Interoception, Emotion Regulation, and Prosocial Behavior in Preschool Children

  • Zamara Cuadros,
  • María José Escobar-Falla,
  • Marisol Correa and
  • Eduar Herrera

Background/Objectives: Although early institutionalization has been linked to socioemotional difficulties, its relationship with interoception in early childhood remains unclear. This study examined differences in interoception, emotion regulation, a...

(This article belongs to the Special Issue Advances in Interoception: Theoretical, Experimental, and Clinical Perspectives)
  • Article
  • Open Access
623 Views
12 Pages

Combined Action Observation and Motor Imagery Elicits Superior Frontoparietal Activation in Elite Ski Jumpers: An fNIRS Study

  • Qing Yan,
  • Keying Zhang,
  • Yuyan Wang,
  • Haibin Zhou,
  • Ling Jiang,
  • Chunmei Cao,
  • Laikang Yu and
  • Dong Zhang

Background: Action observation (AO) and motor imagery (MI) are widely used cognitive training strategies. Recent evidence suggests that their combination may enhance motor simulation through synergistic neural mechanisms. However, the effects of this...

(This article belongs to the Special Issue Advances in the Relationship Among Brain, Physical Function, and Exercise Performance: 2nd Edition)
  • Review
  • Open Access
1,392 Views
36 Pages

Neonatal Epilepsy: Beyond Seizures in a Developing Brain—A Narrative Review

  • Giovanni Boscarino,
  • Eleonora Cresta,
  • Lucia Leonardi,
  • Maria Di Chiara,
  • Alberto Spalice and
  • Gianluca Terrin

Neonatal seizures represent the most common neurological emergency in the neonatal period and arise within a uniquely immature and highly dynamic brain. Their recognition is challenging due to frequent electroclinical dissociation, with many seizures...

(This article belongs to the Section Systems Neuroscience)
  • Review
  • Open Access
1 Citations
872 Views
21 Pages

Extensive explorations in neuroscience, psychology, and psychotherapy increasingly recognized the embodied and relational foundations of selfhood, underscoring the need for an integrated framework spanning development, psychopathology, and therapeuti...

(This article belongs to the Special Issue The Future of Psychological Treatments: Precision Approaches and Emerging Methods)
  • Review
  • Open Access
1,312 Views
18 Pages

Beta-Blocker Utilization in Intracranial Arteriovenous Malformations: A Narrative Review of Current Evidence, Mechanistic Rationale, and Potential Adjunctive Therapeutic Applications

  • Thamer Alsharif,
  • Badr Hafiz,
  • Alaa Turkistani,
  • Ziad Alzahrani,
  • Faisal Sukkar,
  • Fahad Okal,
  • Afnan Alkhotani,
  • Mohammed Aref,
  • Mohammed Binmahfoodh and
  • Saleh Baeesa

Background/Objective: Intracranial arteriovenous malformations (AVMs) are high-flow cerebrovascular lesions associated with a significant risk of intracranial hemorrhage, neurological morbidity, and mortality. Current management strategies, including...

(This article belongs to the Section Neurosurgery and Neuroanatomy)
  • Article
  • Open Access
721 Views
17 Pages

Theta and Alpha Oscillations Reflect Distinct Control and Stabilization Processes Across Working Memory

  • Adrián Ávila-Garibay,
  • Geisa B. Gallardo-Moreno,
  • Fabiola R. Gómez-Velázquez,
  • Steven Woltering and
  • Andrés A. González-Garrido

Background/Objectives: The oscillatory dynamics underlying stage-specific processing in working memory (WM) remain incompletely characterized, particularly under varying memory loads. We examined the load-dependent modulation of theta (4–7 Hz),...

(This article belongs to the Special Issue Electrophysiological Approaches to Cognitive Neuroscience)
  • Article
  • Open Access
735 Views
18 Pages

Perceptual Decision Efficiency and Optimal Sleep Quality Are Associated with Female College Soccer Injury Avoidance

  • Gary B. Wilkerson,
  • Marisa A. Colston,
  • Madison R. Ekas,
  • MacKenzie L. Perkins,
  • Rebecca L. Rinehart,
  • Lynette M. Carlson,
  • Jennifer A. Hogg and
  • Shellie N. Acocello

Background: Sport-related injuries are common, and often recurrent, among female college soccer players. This exploratory cohort study investigated whether perceptual decision efficiency and sleep quality could discriminate between injured and uninju...

(This article belongs to the Section Sensory and Motor Neuroscience)
  • Perspective
  • Open Access
2 Citations
1,328 Views
19 Pages

Chronic Subdural Hematoma Is Not Subdural: Anatomical, Biological, and Therapeutic Implications of a Misleading Definition

  • Matteo De Simone,
  • Elena Ciaglia,
  • Alessandro Santurro,
  • Anis Choucha,
  • Benedetta Messuti,
  • Stefano Fasolino,
  • Rosario De Feo,
  • Daniele Giuseppe Romano,
  • Germano Guerra and
  • Giorgio Iaconetta
  • + 1 author

Chronic subdural hematoma (CSDH) is traditionally described as a post-traumatic blood collection within the subdural space; however, both its anatomical localization and pathophysiology have been increasingly questioned. Ultrastructural and histopath...

(This article belongs to the Section Neurosurgery and Neuroanatomy)
  • Editorial
  • Open Access
346 Views
3 Pages

Editorial Board Collection Series: Insight into Neurosurgery

  • Francesco Signorelli and
  • Massimiliano Visocchi

The present Special Issue brings together five contributions that reflect the evolving landscape of modern neurosurgery, where technological innovation, multidisciplinary integration, and individualized patient care increasingly define clinical decis...

(This article belongs to the Special Issue Editorial Board Collection Series: Insight into Neurosurgery)
  • Review
  • Open Access
990 Views
20 Pages

Informed Consent in Patients with Aphasia: Scoping Review of Clinical Decision-Making Tools and Medico-Legal Issues

  • Lara Brunasso,
  • Rosario Maugeri,
  • Giuseppe Pio Cipollina,
  • Simona Pellerito,
  • Stefania Zerbo,
  • Ginevra Malta,
  • Giovanni Grasso,
  • Domenico Gerardo Iacopino,
  • Antonina Argo and
  • Giuseppe Davide Albano

Informed consent is a core ethical and legal requirement in clinical practice. For individuals with aphasia, language impairments can hinder communication during consent processes. However, aphasia is primarily a language disorder and does not inhere...

(This article belongs to the Section Neurosurgery and Neuroanatomy)
  • Article
  • Open Access
958 Views
15 Pages

The Role of Emotion Dysregulation, Impulsiveness and Rumination in Psychopathology: Evidence from an Italian Sample of Adolescents and Young Adults

  • Sofia Francesca Aprile,
  • Chiara Avanzato,
  • Francesca Alù,
  • Carmen Concerto,
  • Pierfelice Cutrufelli,
  • Ludovico Mineo,
  • Gabriele Privitera,
  • Antonino Petralia,
  • Alessandro Rodolico and
  • Maria Salvina Signorelli
  • + 1 author

Background: Adolescence and emerging adulthood are periods of heightened risk for the onset of psychopathology. Emotion dysregulation (ED), impulsiveness, and rumination are transdiagnostic processes implicated across symptom domains, but their relat...

(This article belongs to the Special Issue Emotional Dysregulation: From Neurodevelopment to Adult Psychopathology—a Transdiagnostic Perspective)
  • Article
  • Open Access
1,249 Views
17 Pages

Differences in Spatial Cognition and Motor–Cognitive Integration by Side of Onset in People with Parkinson’s Disease

  • Ejew Beyla Kim,
  • Morgan Brianna Patrick,
  • Liang Ni,
  • J. Lucas McKay and
  • Madeleine Eve Hackney

Background: Spatial cognition, a skill paramount to survival, is impaired in Parkinson’s disease (PD) but has been little researched. Spatial cognition is utilized during motor–cognitive integration, which impacts daily functioning and qu...

(This article belongs to the Section Sensory and Motor Neuroscience)
  • Review
  • Open Access
909 Views
17 Pages

The Neural Network of Orexin-A: Implications in Feeding Regulation and Obesity–Anxiety Comorbidity

  • Jiarui Wang,
  • Qifan Guan,
  • Xiaokai Wei,
  • Ying Wang,
  • Mengyuan Li and
  • Hongfeng Wang

The comorbidity of obesity and anxiety represents a complex condition with substantial health implications, exacerbating metabolic burden while compromising psychological well-being. Neurons in the lateral hypothalamus (LH) synthesize orexin-A and or...

(This article belongs to the Special Issue Neural Control of Feeding Behavior: Focus on Emotional–Metabolic Comorbidity)
  • Article
  • Open Access
9 Citations
844 Views
14 Pages

Insomnia Severity in Psychiatric Outpatients: Real-World Insomnia Severity Index Data from an Italian Community Mental Health Center

  • Vassilis Martiadis,
  • Enrico Pessina,
  • Azzurra Martini,
  • Marco Marzolla,
  • Chiara Bergesio,
  • Francesca Barbaro,
  • Alex Cavallo,
  • Fabiola Raffone and
  • Carlo Ignazio Cattaneo

Background: Insomnia is common among people with mental health conditions and can exacerbate symptoms, impair functioning and negatively impact treatment outcomes. Community mental health services require practical data to quantify the burden of inso...

(This article belongs to the Section Sleep and Circadian Neuroscience)
  • Article
  • Open Access
830 Views
16 Pages

The Prone-Transpsoas Approach for Single-Position Lateral Corpectomy: A Case Series

  • James G. Lyman,
  • Michael C. Oblich,
  • Rishi Jain,
  • James M. Mossner,
  • Najib El Tecle and
  • Kevin Swong

Objective: To describe the surgical technique and early clinical outcomes of prone-transpsoas single-position corpectomy (PTP-corpectomy) for the management of complex thoracolumbar spinal pathology. Background: PTP-corpectomy is an emerging techniqu...

(This article belongs to the Special Issue Neurosurgery: Minimally Invasive Surgery in Brain and Spine—2nd Edition)
  • Systematic Review
  • Open Access
668 Views
17 Pages

Mapping the Evidence on Oral Health Interventions and Cognitive Status in Alzheimer’s Disease: A Scoping Review

  • Man Hung,
  • Hanna Chriss,
  • Megan Nelson,
  • Janaki O’Callaghan,
  • Corban Ward,
  • Alicia Parry,
  • Jacob Marx and
  • Martin S. Lipsky

Background: Oral health is increasingly recognized as a potentially modifiable factor in Alzheimer’s disease (AD), although its influence on cognitive outcomes remains uncertain. Methods: This scoping review followed the Arksey and O’Mall...

(This article belongs to the Section Neurodegenerative Diseases)
  • Perspective
  • Open Access
1,210 Views
6 Pages

The question “what is an emotion” is as old as the study of the mind and brain. Scientists from Western, English-speaking, Industrialized, Rich, and Democratic (WEIRD) nations tend to adopt certain definitions, but these definitions do no...

(This article belongs to the Special Issue Defining Emotion: A Collection of Current Models)
  • Review
  • Open Access
1,223 Views
16 Pages

Updates in Management of Acute Disorders of Consciousness After Traumatic Injury

  • Taylor S. Hudson,
  • Brianne M. Seagreaves and
  • Amelia W. Maiga

Traumatic injury is one of the most common causes of disorders of consciousness (DoC) worldwide, but the management and prognosis of DoC remain enigmatic. The uncertainty surrounding the natural course of DoC, the tendency of consciousness to wax and...

(This article belongs to the Section Systems Neuroscience)
  • Review
  • Open Access
1 Citations
1,312 Views
17 Pages

Neuroticism, a Big Five trait characterized by emotional instability and susceptibility to negative affect, is a robust transdiagnostic predictor for the onset, severity, and persistence of anxiety disorders, major depressive disorder (MDD), and othe...

  • Review
  • Open Access
813 Views
18 Pages

Background/Objectives: Spirituality is increasingly recognised as a core dimension of holistic and palliative care. Neurodegenerative diseases such as dementia, amyotrophic lateral sclerosis and Parkinson’s disease involve prolonged trajectorie...

(This article belongs to the Section Neurorehabilitation)
  • Review
  • Open Access
890 Views
21 Pages

From Resistance to Redesign—The Emerging Logic of Hybrid Care in Treatment-Resistant Depression

  • Federico Mucci,
  • Riccardo Gurrieri,
  • Siham Bouanani,
  • Matteo Gambini,
  • Gerardo Russomanno and
  • Donatella Marazziti

Background/Objectives: Treatment-resistant depression (TRD) remains one of the most urgent unmet needs in psychiatry, while its therapeutic pipeline is evolving rapidly. To characterize current development trajectories, we conducted a registry-anchor...

(This article belongs to the Special Issue Mental Disorders: Diagnosis, Symptoms, Assessment, and Treatment)
  • Systematic Review
  • Open Access
1 Citations
770 Views
22 Pages

Neural Correlates of Inhibitory Control in Impulsivity Traits in Non-Ecological Human–Computer Tasks: An ALE Meta-Analysis

  • Chiara Noferini,
  • Gioele Gavazzi,
  • Fabio Giovannelli,
  • Chiara Puddu,
  • Mario Mascalchi,
  • Massimo Cincotta,
  • Liberatore Tramontano,
  • Carlo Cavaliere and
  • Maria Pia Viggiano

Background/Objectives: Response inhibition is the capacity to restrain impulsive actions, representing a pivotal facet of cognitive control. Although several studies report a dynamic relationship between impulsivity and inhibitory control, the neural...

(This article belongs to the Special Issue Cognitive Processes in Human–AI Interaction: Neural and Behavioral Insights)

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Brain Sci. - ISSN 2076-3425