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Brain Sciences, Volume 15, Issue 3

March 2025 - 110 articles

Cover Story: Sleep appears to have a central role in Freud’s original model, since dreaming is considered the guardian of sleep. The function of dreaming is to protect sleep from disruption, thereby preserving its biological integrity. Freud also recognized sleep as an active process, given that human beings voluntarily withdraw from the external world to sleep. The discovery of REM sleep in the 1950s led psychoanalysts to view sleep as the necessary backdrop against which dreaming occurs. Although Freud dismissed the clinical importance of sleep disturbances, authors have since suggested that sleep disturbances might have specific psychological significance. Thanks to Freud’s work, the desire to sleep assumes an important role as a psychological, active factor that contributes to the occurrence and function of sleep. View this paper
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Articles (110)

  • Article
  • Open Access
1 Citations
2,252 Views
20 Pages

Background/Objectives: Chronotypes significantly influence sleep quality, daily performance, and overall activity levels. Although there is growing evidence indicating that individuals with a late chronotype are more likely to experience cognitive de...

  • Review
  • Open Access
2 Citations
4,014 Views
23 Pages

Lactylation and Central Nervous System Diseases

  • Ye Chen,
  • Dongqiong Xiao and
  • Xihong Li

As the final product of glycolysis, lactate serves as an energy substrate, metabolite, and signaling molecule in various diseases and mediates lactylation, an epigenetic modification that occurs under both physiological and pathological conditions. L...

  • Article
  • Open Access
1,344 Views
15 Pages

ATP Alters the Oxylipin Profiles in Astrocytes: Modulation by High Glucose and Metformin

  • Alexey I. Drozhdev,
  • Vladislav O. Gorbatenko,
  • Sergey V. Goriainov,
  • Dmitry V. Chistyakov and
  • Marina G. Sergeeva

Background: Astrocytes play a key role in the inflammatory process accompanying various neurological diseases. Extracellular ATP accompanies inflammatory processes in the brain, but its effect on lipid mediators (oxylipins) in astrocytes remains elus...

  • Article
  • Open Access
3 Citations
4,110 Views
20 Pages

The Use of Novel Stimulants in ADHD Self-Medication: A Mixed Methods Analysis

  • Tayler Holborn,
  • Fabrizio Schifano,
  • Emma Smith and
  • Paolo Deluca

Background: Numerous individuals suffer from attentional issues, such as ADHD. While medication is considered the first-line treatment, it is unavailable to some. As a result, certain individuals are choosing to self-medicate with novel stimulants, a...

  • Article
  • Open Access
3 Citations
1,643 Views
19 Pages

Background/Objectives: Activation of cannabinoid CB1 or CB2 receptors induces the death of glial progenitors from the chick retina in culture. Here, by using an enriched retinal glial cell culture, we characterized some mechanisms underlying glial de...

  • Article
  • Open Access
1 Citations
1,934 Views
17 Pages

Lycorine Pre-Treatment Alleviates Microglia Inflammation After Cerebral Ischemia by Inhibiting NF-κB Phosphorylation

  • Wuyan Zheng,
  • Wanyu Wu,
  • Yuhan Li,
  • Bo Qin,
  • Yuping Wang,
  • Yunhan Zeng,
  • Betty Yuen Kwan Law and
  • Vincent Kam Wai Wong

Background: Middle-aged and elderly individuals may experience detrimental health effects due to ischemic stroke (IS). The inflammatory response triggered during IS exacerbates neuronal damage, becoming a barrier to effective IS treatment and leading...

  • Article
  • Open Access
1 Citations
2,435 Views
20 Pages

Kawaii-Ness Mediates Between Demographic Variables, Happiness, and Brain Conditions

  • Keisuke Kokubun,
  • Kiyotaka Nemoto,
  • Taiko Otsuka,
  • Maya Okamoto,
  • Yuko Shiga,
  • Yuya Makizato,
  • Aya Komaki and
  • Yoshinori Yamakawa

Background/Objectives: In many societies, especially in highly masculine societies like Japan, being a man, getting older, engaging in knowledge work, and earning a high annual salary are seen as conditions for success. On the other hand, an increasi...

  • Article
  • Open Access
1 Citations
2,065 Views
13 Pages

Cross-Modal Interactions and Movement-Related Tactile Gating: The Role of Vision

  • Maria Casado-Palacios,
  • Alessia Tonelli,
  • Claudio Campus and
  • Monica Gori

Background: When engaging with the environment, multisensory cues interact and are integrated to create a coherent representation of the world around us, a process that has been suggested to be affected by the lack of visual feedback in blind individ...

  • Review
  • Open Access
3,658 Views
19 Pages

Background/Objectives: Suicidal behaviors (SBs) and non-suicidal self-injury (NSSI) are significant mental health concerns in children and adolescents. The hypothalamic–pituitary–adrenal (HPA) axis, of which cortisol is a key hormone, has...

  • Article
  • Open Access
1,385 Views
14 Pages

Background/Objectives: Synchronized beta-band oscillations (14–30 Hz) are critical for sensorimotor processing and motor performance. Modulating beta activity either locally in targeted brain regions or globally across sensorimotor networks may...

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Brain Sci. - ISSN 2076-3425