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Brain Sciences, Volume 15, Issue 2

February 2025 - 119 articles

Cover Story: Experience the future of epilepsy surgery with the cutting-edge frameless implantation of depth electrodes! Advanced automatic intraoperative CT-based registration delivers pinpoint accuracy, matching that of the traditional frame-based methods while seamlessly integrating into the surgical workflow. There is no longer a need to worry about the hassle of manual registration challenges; we can instead welcome this precision-driven technology that optimizes trajectory planning for safer and more reliable procedures. By refining every step of the process—from imaging to electrode placement—this innovative approach enhances patient safety and maximizes success in identifying the epileptogenic zone. View this paper
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Articles (119)

  • Systematic Review
  • Open Access
10 Citations
5,082 Views
25 Pages

Cholinesterase Inhibitors from Plants and Their Potential in Alzheimer’s Treatment: Systematic Review

  • Maryam N. ALNasser,
  • Ghadir M. Alboraiy,
  • Eman M. Alsowig and
  • Fatimah M. Alqattan

19 February 2025

Introduction: Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by memory loss and cognitive decline, primarily due to dysfunction of acetylcholine caused by acetylcholinesterase and butyrylcholinesterase. While synthetic c...

  • Article
  • Open Access
2 Citations
2,783 Views
16 Pages

Gender Differences in Clinical and Biochemical Variables of Patients Affected by Bipolar Disorder

  • Luigi Piccirilli,
  • Enrico Capuzzi,
  • Francesca Legnani,
  • Martina Di Paolo,
  • Anna Pan,
  • Alessandro Ceresa,
  • Cecilia Maria Esposito,
  • Luisa Cirella,
  • Teresa Surace and
  • Ilaria Tagliabue
  • + 2 authors

19 February 2025

Introduction: Bipolar disorder (BD) affects over 1% of the global population and significantly impacts psychosocial functioning and life expectancy. This manuscript has the objective of investigating gender differences in the clinical and biochemical...

  • Review
  • Open Access
2 Citations
4,684 Views
10 Pages

Advances in Coccygectomy: A Comprehensive Review Evaluating Surgical Techniques for Coccygodynia

  • Barnabas Obeng-Gyasi,
  • Ethan D. L. Brown,
  • Anoop Sai Chinthala and
  • Gordon Mao

19 February 2025

Background: Coccygodynia presents significant challenges in diagnosis and treatment. While coccygectomy has emerged as a crucial intervention for refractory cases, significant heterogeneity exists in surgical techniques. Traditional approaches are in...

  • Article
  • Open Access
2 Citations
2,034 Views
16 Pages

19 February 2025

Background: Prenatal stress has been reported to harm the physiological and biochemical functions of the brain of the offspring, potentially resulting in anxiety- and depression-like behaviors later in life. Trans-Resveratrol (RESV) is known for its...

  • Article
  • Open Access
3 Citations
1,982 Views
12 Pages

Prognostic Biomarkers in Isocitrate Dehydrogenase Wild-Type Glioblastoma: A Focus on B7-H3

  • Ramazan Oğuz Yüceer,
  • Seyhmus Kaya,
  • Sema Nur Balcı,
  • Hatice Reyhan Eğilmez,
  • Mukaddes Yılmaz and
  • Eda Erdıs

19 February 2025

Background: Isocitrate dehydrogenase (IDH) wild-type (wt) glioblastoma is an aggressive malignancy associated with poor clinical outcomes, marked by high heterogeneity and resistance to treatment. This study aims to investigate the prognostic signifi...

  • Brief Report
  • Open Access
1,310 Views
9 Pages

The Value of Non-Invasive Optimal Vessel Analysis Quantitative Magnetic Resonance Angiography for Studying Flow and Collateral Patterns in Patients with Bilateral Carotid Steno-Occlusive Disease

  • Fiona Helg,
  • Elisa Colombo,
  • Corinne Inauen,
  • Lara Maria Höbner,
  • Martina Sebök,
  • Tilman Schubert,
  • Jorn Fierstra,
  • Antonio Spinello,
  • Susanne Wegener and
  • Andreas R. Luft
  • + 3 authors

19 February 2025

Background/Objectives: Bilateral steno-occlusive disease of the internal carotid artery (ICA) carries an increased stroke risk with associated high morbidity and mortality. Management of these patients is often complex. In this study, we evaluate the...

  • Article
  • Open Access
1,764 Views
13 Pages

P300 to Low and High Frequency Stimuli Are Not Influenced by Intensity in Adults with Normal Hearing

  • Giulia Cartocci,
  • Garrett Cardon,
  • Julia Campbell,
  • Bianca Maria Serena Inguscio,
  • Dario Rossi,
  • Fabio Babiloni and
  • Anu Sharma

18 February 2025

Background/Objectives: Since high frequencies are susceptible to disruption in various types of hearing loss, a symptom which is common in people with tinnitus, the aim of the study was to investigate EEG cortical auditory evoked and P300 responses t...

  • Article
  • Open Access
1,584 Views
12 Pages

17 February 2025

Background/Objectives: Hemispatial neglect is common after stroke but is often evaluated only after right hemisphere (RH) stroke. We sought to determine the prevalence of two types of neglect, viewer-centered neglect (VCN) and stimulus-centered negle...

  • Article
  • Open Access
2 Citations
1,267 Views
23 Pages

Simultaneous Multi-Treatment Strategy for Brain Tumor Reduction via Nonlinear Control

  • Muhammad Arsalan,
  • Xiaojun Yu,
  • Muhammad Tariq Sadiq and
  • Ahmad Almogren

17 February 2025

Background: Recently proposed brain-tumor treatment strategies prioritize fast reduction of tumor cell population while often neglecting the radiation or chemotherapeutic drug dosage requirements to achieve it. Moreover, these techniques provide chem...

  • Review
  • Open Access
13 Citations
8,809 Views
18 Pages

Neuroinflammatory and Immunological Aspects of Fibromyalgia

  • Kate Findeisen,
  • Emma Guymer and
  • Geoffrey Littlejohn

17 February 2025

Fibromyalgia is a common, high-impact condition of chronic widespread pain and sensory dysfunction associated with altered central and peripheral sensory processing. A growing body of evidence supports the role of neuroinflammation and immune changes...

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Brain Sci. - ISSN 2076-3425